Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
6 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2023-12); ; ; Initial studies on impaired glucose-insulin homeostasis in heroin dependents have not defined the impact of concomitant hepatitis C infection (HCV), which has been strongly associated with the development of insulin resistanceand metabolic syndrome (MS). The aim of our study was to evaluate the association of heroin dependence with glucose-insulin homeostasis and MS in heroin dependents with HCV seronegativity. Materials and methods: The study was prospective and cross-sectional, including 160 heroin dependents compared to a control group of 60 participants.MS was diagnosed using International Diabetes Federation criteria. The homeostatic model assessment for insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-%B) were used for assessing insulin resistance and β-cell function of pancreas. Results: MS was detected in 9.32% of heroin addicts. Heroin dependents with MS compared to dependents without MS were older, had higher BMI, waist circumference and significantly higher systolic and diastolic blood pressure, increased triglycerides (F=8.233, df=2, p<0.001), apoB (F=8.154, df=2, p=0.001), and reduced HDL-C (F=25.926, df=2, p<0.001) and apoA-I (F=16.406, df=2, p<0.001), significantly increased inuslinemia (F=4.928, df=2, p<0.05), insulin resistance-HOMA-IR (F=4,928, df=2, p<0,05) and insignificantly increased pancreatic β-cell function (194.66 ±224.05) (F=2.461, df=2, p>0.05). Conclusions: Insulin resistance and МS, independent of HCV, was also registered in heroin dependence. Timely recognition will enable more successful treatment of comorbidities and illicit drug dependence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determination of HSP 70 as one of the important inputs in the detection and definition of the degree of myocardial ischemic events.(Walter de Gruyter GmbH, 2023-05); ; ; ; Janicevic Ivanovska, Danijela - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Differences in red blood cells distribution (RDW) at patients with ACS(Walter de Gruyter GmbH, 2023-05); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ESTIMATED CENTRAL OBESITY INDEX –WORTHWHILE SCREENING TEST PROCEDURE OF ABDOMINAL OBESITY(Institute of Knowledge Management, 2019); Janicevic Ivanovska, DanijelaCentral obesity index (COI) is an indicator of central, abdominal obesity, which is the main characteristic of the metabolic syndrome. Dual-energy x-ray absorptiometric (DXA) assessment of the body fat distribution was performed through the COI values determined with a scan of the entire body in comparison toestimated COI values (eCOI) on spine and hip performed scans. COI was determined as a ratio of android (A) tissue percent fat (A-Tf%) and gynoid (G)-Tf% (COI=A/G-Tf%) as well as eCOI=eA/eG-Tf% in 3 groups of women: 1st group of women with Cushing’s syndrome(CS) (n=14), 2nd group of obese (O) women(n=21), 3rd group of non obese healthy women (C) (n=22). The examinees were not different according to their age, which was 44.32±13.83 years in the 1stgroup, 43.33±12.58 years in the 2ndgroup and 42.56±14.67 years in the 3rdgroup, as well as according to their BMI, which was 30.02±5.02 kg/m2in CS, 29.66±4.88 kg/m2 in O, but it was in normal range 21.76±1.43 kg/m2in non obese control group of healthy women.The values of eA, eG and eA/еG were not significantly different compared to the correspondent values A-Tf%, G-Tf% and A/G-Tf% in all examined groups (p>0.05). The values of eA and A-Tf% in CS were significantly higher compared to O (P<0.05), as well as compared to C and O+C and in O compared to C (p<0.0001). COI value (1.05±0.15) and eCOI (1.04±0.1) in CS were significantly higher compared to O (p<0.006 and p<0.008) and highly significantly higher compared to C, O+C and in O compared to C (p<0.0001). Estimated values eA, eG and eA/eG correlated highly significantly positively with the correspondent values A-Tf%, G-Tf% and A/G-Tf% (p<0.0001) and COI values correlated highly significantly with eCOI, eA and A-Tf% (p<0.0001) and not significantly with G-Tf% and eG (p>0.05) in O confirming COI positive association with central, abdominal fat distribution.Conclusion: DXA indexes COI and eCOI discovered extreme central body fat distribution in CS women,differentiated them significantly and precisely from C and CO, and could be used as diagnostic DXA indexes of extreme central, abdominal obesity in CS and non CS abdominal obese women in DXA body composition and fat distribution assessment. Determination of eCOI is reliable, more practical and faster, with lower radiation and is more acceptable compared to COI, and it can be a routine screening procedure forbody composition and body fat distribution assessment, during regular spine and hip scans for osteoporotic risk assessment instead of COI body fat distribution determination with total body composition measured scans which are used in scientific studies and are not necessary to be performed in clinical body fat distribution examinations. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY FAT DISTRIBUTION AND LIPID PROFILE CHANGES AFTER WEIGHT LOSS – A CASE REPORT(Institute of Knowledge Management, 2019); Janicevic Ivanovska, DanijelaThe aim of this study was to discover the relationship between body fat distribution and lipid profile changes after weight loss. In this case report following subject’s parameters were determined before and after weight loss of 12 kg: body mass index (BMI), body weight (BW), total, trunk and legs fat mass (FM) with dual energy xray absorptiometry (DXA) and their ratios legs/trunk and legs/total FM indexes of abdominal fat distribution. Lipid profile was also determined before and after weight loss: total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, LDL/HDL-C, TC/HDL-C. BW of 63 kg and BMI value of 28.74 kg/m2 before the weight loss lowered to 51kg and 22.55 kg/m2. The percentage difference between the change in BMI and BW was statistically not significant (p=0.782). Legs/total FM index value increase from 0.36 to 0.39 was significant (p<0.025). Legs/trunk FM index value increase from 0.67 to 0.76 was also significant (p<0.043). Legs, total and trunk FM had not significant reduction (p>0.05), but the percentage difference between their changes, during weight reduction was statistically significant (p=0.0001). TC, HDL-C, LDL-C, LDL/HDL-C, TC/HDL-C changes were also significant. The percentage difference between the change in BMI and BW to normal levels was statistically not significant, but the percentage difference between the changes in DXA indexes of visceral, abdominal obesity was significant and it was associated with significant reduction of atherogenic lipid profile indicating reduced atherogenic risk. These results confirmed that DXA measurements of abdominal fat distribution are very useful in studies related to obesityassociated disease risk. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lipid profile changes relations to body fat distribution changes determined with dual-energy x-ray absorptiometry during the weight loss(Institute of Knowledge Management, 2019);