Faculty of Medicine

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Author: search.filters.author.Ivkovska, Tamara

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    Inflamed Mesenteric Pseudocyst Associated with Meckel’s Diverticulitis: Cause or Consequence
    (Knowledge E DMCC, 2024-12-08)
    Talev, Stefan
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    Avramovska, Maja
    ;
    Avramovski, Petar
    ;
    Nikleski, Zorica
    ;
    Ivkovska, Tamara
    Introduction: Mesenteric pseudocyst describes an abdominal mass that appears on small bowel mesentery or mesocolon, or at any part of the abdomen and retroperitoneum. This paper aims to emphasize the non-specific clinical appearance and highlight Meckel’s diverticulitis as a potential cause of the development of pseudocyst. Case Report: A 26-year-old male with a palpable mass in the right upper abdominal quadrant and an increased body temperature of 38.3∘C was admitted for further medical investigation. Computed tomography (CT) presented a cystic mass with a diameter of 5.5 cm, and emergency laparotomy was performed. Wedge resection of pathologic findings of small bowel, its mesenterium, and the cyst mass associated with nearby Meckel’s diverticulum was performed. Discussion: Meckel’s diverticulum can be considered as a risk for developing mesenteric pseudocyst, because of its frequent exacerbation of chronic inflammation. This report adds to the limited literature on the association between Meckel’s diverticulum and mesenteric pseudocysts, providing valuable insights that can guide future clinical evaluations and surgical interventions. Early and accurate diagnosis, aided by imaging techniques such as CT and magnetic resonance imaging (MRI), is essential for effective management. This case highlights the potential link between chronic inflammation in Meckel’s diverticulum and the formation of mesenteric pseudocysts. Conclusion: This case highlights the need to consider Meckel’s diverticulitis in patients with mesenteric pseudocysts, suggesting a possible pathophysiological link between them. Surgical resection is recommended for effective management.
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    CORRELATION BETWEEN HISTOLOGICAL FINDINGS AND CYTOLOGICAL FINDINGS AND HPV STATUS IN PATIENTS WITH HSIL - RETROSPECTIVE STUDY
    (Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2025-01-01)
    Stanojevic, Verdi
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    Mircevska, Megi
    Introduction. Cervical intraepithelial neoplasia (CIN) and invasive cervical cancer are most commonly caused by human papillomavirus, which causes malig¬nant transformation of cervical epithelial cells. The aim of this study was to investigate the association between different HPV types and histological changes of the cervix in patients in our hospital. Methods. In the period from January 2022 to Decem¬ber 2023, an analysis of 100 samples was made with histological findings confirmed by biopsy from the University Clinic for Gynecology and Obstetrics in Skopje. The relationship between HRHPV and high-grade CIN and CIS, as well as the age-dependent prevalence of single HPV infection, were examined. Results. In both CIN2, CIN3 and CIS group, HPV16, 18, 31, 33 and 58 were detected as the top 5 high-risk human papillomavirus (hrHPV) types. HPV16 was the predominant genotype in CIN2, CIN3 and CIS, with 44.23%, 60.53% and 90% respectively. The prevalence of HPV16 was most common in all age groups. The peak incidence of CIN2 was observed from 31-40 and 41-50 years (28.85%), and CIN3 from 21-30 (28.95) and 51-60 years (23.68), and CIS from 31-40 (40%) and 41-50 years of age (30%). Conclusion. If circumstances permit, women between the ages of 21 and 60 are advised to undergo norma¬tive screening for high-grade CIN. Patients who test positive for HPV16 should be prioritised for opportu¬nistic screening. Patients infected with other forms of HPV should also be treated seriously if they are ladies 61 years of age or older. The most prevalent genotypes in our patients were HPV16, 18, 31, 33 and 58. Therefore, a vaccine including these dominant genotypes may be crucial for preventing cervical cancer.