Faculty of Medicine
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Item type:Publication, Rituximab in treatment of a patient with granulomatosis with polyangitis - a case report(Македонско лекарско друштво = Macedonian medical association, 2023-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Severe Complicated secondary antiphospholipid syndrome conjointly with lupus erythematosus -case report(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2025-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A complicated case of granulomatosis with polyangiitis(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2025-01); ; Granulomatosis with polyangiitis, formerly known as Wegener's granulomatosis, is a condition often presenting with granulomatous vasculitis of both the upper and lower respiratory tracts together with glomerulonephritis. Here we present a case of a 17-year-old female patient, who presented with symptoms of pansinusitis with other symptoms gradually following. She was treated with cyclophosphamide which was later switched to rituximab and is now in remission. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Drug-induced vasculitis with multi-organ injury in a splenectomised patient and mycophenolate mofetil therapy – a case report(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2025-02); ; ; We present a case with p-ANCA positive general vasculitis and severe multi-organ injury in a splenectomised patient, which developed during ceftriaxone and metamizole administration for treatment of upper respiratory infection. Case report: A middle-aged woman with 400C fever and sore throat got a treatment with IV metamizole and ceftriaxone in a local hospital. She had a post- traumatic splenectomy 5 years ago. After metamizole, during ceftriaxone administration she felt burning in her face, developing red rush which spread over the face and darkened, later extended to her palms and feet. After visiting several clinics, she was referred finally to the University Clinic for Toxicology in Skopje. On admission, she had hypotension, hypoxemia, livid oro-pharynx, necrotic vasculitis with predominant facial distribution and unpalpable purpura on the extremities. The examinations revealed high levels of inflammatory biomarkers, anaemia, polyserositis, acute pancreatitis, hepatomegaly, acute kidney injury, disseminated intravascular coagulation, right eye vitreous haemorrhage and rhabdomyolysis. Microbiological investigations were negative. Immuno-serology showed positive p-ANCA. The acute renal failure and polyserositis resolved under methylprednisolone, meropenem, furosemide, low molecular weight heparin, fresh frozen plasma, and other symptomatic therapy, which decreased the inflammatory biomarkers, but DIC with thrombocytopenia persisted. A skin biopsy finding was inconclusive. After 25 days, the rheumatologist recommended mycophenolate mofetil with prednisolone peroral therapy during two years that resulted in stabilizing the vasculitis. The patient maintained stable after therapy discontinuation. Conclusions: Drug-induced vasculitis has the potential to induce a severe multi-organ injury with life-threatening complications. Mycophenolate mofetil procured a safe and successful treatment of drug-induced vasculitis. Splenectomy may be a potential risk factor for immunomodulated response to drugs and drugs interactions, especially during infections. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of the risk of vertebral fractures and their incidence in postmenopausal patients with rheumatoid arthritis(2025-04-10); ; Karadjova Stojanovska, AnzhelikaObjective The incidence of vertebral fractures and their association with the activity, duration of the disease, therapeutic modality, lifestyle, and functional impairments. Material and methods This is a cross-sectional analytical study that includes 150 patients with an established diagnosis of definitive RA according to the ACR (American College of Rheumatology) criteria from 1987, treated on an outpatient and inpatient basis at the University Clinic of Rheumatology in Skopje between 2019-2021. The subjects are females aged 50-80 years, postmenopausal women with a menopause duration of ≥ 2 years. We include patients who have not previously been treated with bisphosphonate therapy. All subjects with RA were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and/or disease-modifying antirheumatic drugs (DMARDs) and corticosteroids (CS). Results The prevalence of vertebral fractures (VF) in postmenopausal patients with RA is 54.6%. Among 58 patients, VF with grade 2 reduction is 31.3%, mild fracture is 18.0%, and severe fracture is 5.3%. In patients due to CS therapy, there is an increased occurrence of VF, smoking is one of the significant risk factors (p>0.05), along with the duration and activity of the disease, while increased BMI reduces the risk of developing these fractures. In patients with vertebral fractures, osteopenia is registered in 51.2%, normal findings in 28.0%, and osteoporosis in 19.3%. There is a statistically significant association between osteopenia and normal findings versus vertebral fractures (Pearson Chi-square: 4.0793, df=1, p=.043412), as well as between osteoporosis and normal findings versus vertebral fractures (Pearson Chi-square: 4.7127, df=1, p=.029940) Conclusions RA represents a risk factor for the development of osteoporosis and increases the risk of vertebral and non-vertebral fractures in postmenopausal patients with RA. This risk is proportional to the reduction in weight, duration, and activity of the disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE ROLE OF MICROBIOME IN IMMUNE-MEDIATED UVEITIS -LITERATURE REVIEW(Macedonian Association of Anatomists and Morphologists, 2024); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RITUXIMAB IN TREATMENT OF A PATIENT WITH GRANULOMATOSIS WITH POLYANGIITIS – A CASE REPORT(Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2024-12-15) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ROLE OF IMMUNOMODULATORY AND BIOLOGICAL THERAPY IN THE TREATMENT OF PATIENTS WITH BEHCET'S UVEITIS -CASES FROM CLINICAL PRACTICE(Macedonian Association of Anatomists and Morphologists, 2023-11); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Multicenter, Open-Label, Long-term Extension to Describe the Safety of Tocilizumab in Patients with Early, Moderate to Severe Rheumatoid Arthritis(Science Publishing Group, 2020); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, АSSESSMENT OF OSTEOPOROSIS AND OCCURRENCE OF VERTEBRAL FRACTURES IN POSTMENOPAUSAL PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH SMALL DOSES OF GLUCOCORTICOIDS(Институт за јавното здравје на Република Македонија = Institute of public health of the Republic of Macedonia, 2020-12-11); ; ;