Faculty of Medicine

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Author: search.filters.author.Gjinovska Tasevska, Elena

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    P158 Fungal airway colonisation in cystic fibrosis patients in the Institute for Respiratory Diseases in Children - Skopje, Republic of North Macedonia
    (Elsevier BV, 2021)
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    Vidoevska, A.
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    Popova, Gorica
    Respiratory tract of cystic fibrosis (CF) patients has polymicrobial colonisation. Clinical impact of the fungal colonisation in CF patients is still much less understood. Here, we provide epidemiological data of fungal airway colonisation in CF patients in CF department in the Institute for Respiratory Diseases in Children in Skopje, Republic of North Macedonia.
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    P167 Prevalence of liver disease in cystic fibrosis patients in the Institute for Respiratory Diseases in Children - Skopje, Republic of North Macedonia
    (Elsevier BV, 2021)
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    Vidoevska, A
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    Gjinovska Tasevska, Elena
    Our aim is to provide epidemiological data of liver disease in cystic fibrosis (CF) patients in the CF Department in the Institute for Respiratory Diseases in Children in Skopje, Republic of North Macedonia.
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    P263 Impaired bone mineralisation in children with cystic fibrosis
    (Elsevier BV, 2020-06)
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    Gjinovska Tasevska, Elena
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    P330 Clinical effects of probiotic supplementation in patients with cystic fibrosis in the Republic of Macedonia
    (Elsevier BV, 2019-06)
    Jakovska Maretti, T
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    Gjinovska Tasevska, Elena
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    EPIDEMIOLOGY, TREATMENT, AND COMPLICATIONS OF CROUP SYNDROME IN CHILDREN
    (Macedonian Association of Anatomists and Morphologists, 2020)
    Gjinovska Tasevska, Elena
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    Doksimovski, Filip
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    Tasevska Rajkovikj, Аna
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    Petlichkovska, Sandra
    Introduction: Croup syndrome is an urgent pediatric condition. It is characterized by the abrupt onset, most commonly at night, of a barking cough, that is usually accompanied by inspiratory stridor, hoarseness and respiratory distress resulting from upper-airway obstruction. This is the most common reason why parents are upset and immediately seek medical help. Objective: This study aimed to evaluate the frequency, treatment, and possible complications of croup syndrome in children hospitalized at our institute. Materials and methods: In our retrospective study we examined 56 pediatric cases with croup syndrome that were hospitalized in our Institute and we analyzed gender and age, the season in which we had the most frequent hospitalizations of children with croup syndrome, as well as treatment and possible complications after completion of croup symptoms. Period of examination was one year. Results: Mean age at diagnosis of children with croup was 26,5 ±2.6 months (range from 45 days to 8 years). As well the world statistics we got a larger number of hospitalized boys with croup syndrome, rather than girls (ratio 2,3:1). Regarding the period of the year, the autumn period was dominant. As far as the treatment, we noticed significant number of children with moderate to severe croup syndrome that required in-patient care. All of them received nebulized adrenalin as well as parenteral corticosteroid. The average duration of the hospitalizations that occurred in our unit for close monitoring and semi-intensive care was 5 days (1-14d). Antibiotics were used in 71% (n=40). Most common comorbidity was pneumonia and bronchopneumonia (14,2%, n=8). None of the children was of need of intubation and referral to intensive care unit. Conclusion: Our one-year research has documented considerable number of children with the necessary hospitalization, as many as 10% of hospitalized children in our Institute were due to moderate to severe croup syndrome. The sex, the age of the children as well as the season are most often in line with world statistics. We are noticing high percent of hospitalized patients with moderate croup. There is evident discrepancy between the use of antibiotics and its duration in our practice in comparison with other reports. These observations lead to reassessment of the hospitalization criteria as well as more rational use of antibiotics.
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    ETHICAL ASPECTS IN CLINICAL TRIALS IN CHILDREN
    (Македонско лекарско друштво = Macedonian Medical Association, 2021)
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    Arnaudov, Dimitar
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    Conducting clinical trials in children has particular importance as they strive to provide optimal care and therapy for this specific group of patients, but their implementation is still complex. This is often due to the lack of agreed-upon research objectives, unresolved questions about informed consent, and the general perception that children are a vulnerable group of subjects. For providing the best clinical care for pediatric subjects, it is important to conduct careful, effective research that has a scientific basis to answer important clinical questions. The main challenge of pediatric research is the risk and therefore the question arises whether the purpose of the research justifies the risks associated with the study? The four ethical principles should serve as a framework in the process of conducting clinical trials in children: benefacere, justice, respect for personality and confidentiality. One principle is no more or less important than the others, so all four must be taken into account when conducting a research. The ethical principle of "respect for personality" is the basis for the process of informed consent. It is a legal document by which the patient voluntarily agrees to participate in a research. The informed consent must be signed by child's legal guardian(s) and this step cannot be delegated to other family members or friends unless there is a legal basis. However, with proper planning and monitoring the study process, a research can be conducted in children even though they are considered as a vulnerable population.