Faculty of Medicine

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    Interventional procedure in breast lesions- core-biopsy
    (Macedonian Association of Anatomists and Morphologists, 2017)
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    Adrenal tumors as incidentalomas: report of our experience
    (Macedonian Association of Anatomists and Morphologists, 2017)
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    Computed tomography or magnetic resonance imaging - our experiences in determining preoperative TNM staging of bladder cancer
    (Macedonian Academy of Sciences and Arts, 2013)
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    Lazarova, Aleksandra
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    FREQUENCY, IMAGINIG PATTERNS AND PITFALLS IN BLUNT ABDOMINAL TRAUMA, A SINGLE CENTER EXPERIENCE STUDY
    (Macedonian Association of Anatomists and Morphologists, 2023)
    Ramadani, Pranvera
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    Blunt abdominal trauma is a life-threatening condition and imaging is key in identifying the next step in patient management. The objective of this study is to determine the frequency and pitfalls of blunt abdominal trauma findings in multiphasic Multidetector Computed Tomographic (MDCT) examinations in patients with road traffic injuries and falls in the setting of polytrauma. After institutional review board approval with a waiver of informed consent was obtained, a retrospective study was performed focusing on a three-month period in 2023, from May to July in patients referred to our department with the diagnosis of superficial injuries involving multiple body regions – T00. A review of the Picture Archiving and Communication System (PACS), the electronic medical records and dictated reports identified patients who met the criteria of abdominal blunt trauma. A total number of 321 patients were identified, who met the criteria of superficial injuries involving multiple body regions (average age, 37.5 years). 220 patients were male. 2,8% (9 patients) had imaging findings of blunt abdominal trauma. 55,5 % of patients had spleen traumatic injuries, the remaining percentage was liver, kidney, retroperitoneal hematoma and isolated free abdominal fluid. MDCT and administration of intra venous contrast is crucial in recognizing many of the spectral findings blunt abdominal trauma. A protocol of biphasic “Combi” scan should be implemented in order to minimize radiation exposure and duration of the scan. Multiphasic Computed Tomography (CT) acquisition is key to avoid pitfalls.
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    PERSISTENT TRIGEMINAL ARTERY - ANATOMICAL FEATURES AND CLINICAL SIGNIFICANCE
    (Macedonian Association of Anatomists and Morphologists, 2023)
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    Persistent trigeminal artery is the most common primitive carotid basilar anastomosis that persists in adulthood. The overall incidence of persistent trigeminal artery is between 0.2 to 0.76%. PTA are known to be associated with a wide range of pathology. The aim of this study was to describe the morphological characteristics of the PTA and to emphasize its clinical significance. We examined radiographs from patients who had CT angiography undertaken for a variety of clinical reasons, performed as a part of their medical treatment at the University Institute for Radiology in Skopje, RN Macedonia. The study population included 234 patients, 130 male and 104 females, mean age 57.8 years. In one patient we found PTA with overall incidence of 0.42%. CTA revealed a left PTA that arise from the internal carotid artery and communicate with the basilar artery between the origin of the anterior inferior cerebellar artery and the superior cerebellar artery. Although anatomically interesting, an awareness of the anatomy and variations of the brain arteries is clinically important for radiologists and surgeons for save performance of procedures, and forensic pathologists since variants may have forensic consequences.
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    THE ROLE OF T2W PULSE SEQUENCE AND DIFFUSION WITH ITS NUMERICAL ADC MAP IN PROSTATE CANCER DIAGNOSIS
    (Macedonian Association of Anatomists and Morphologists, 2023)
    Kostova, Masha
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    In patients with increased PSA (prostate-specific antigen), the next diagnostics tool is transrectal ultrasound-guided biopsy-TRUS. Multiparametric magnetic resonance imaging (mp MRI) as non invasive diagnostic tool is used as a triage test to avoid biopsy, as well as to improve the diagnostics. In our study we want to prove the clinical meaning of T2W pulse sequence and diffusion as a part of mp MRI in prostate malignant lesions detection and their distinction from the benign lesions. This cohort prospective study included 100 patients with increased levels of PSA from 4 ng/ml to 76 ng/ml. The MRI equipment used was Siemens Essenza1,5T with body coil. The results from the T2W pulse sequence and diffusion are correlated with the values of diffusion and ADC map, in which the suspected zones are marked on a template. Patients undergo biopsy depending on the PIRADS (prostate-imaging and reporting data system) classification. The MRI results and the pathohistological findings are then compared. Clinically significant cancer is considered to be a cancer with a Gleason score 6, diameter > 6mm. The values of diffusion with its numerical ADC map are considerably lower for malignant nodules compared to benign ones. Hyposignal of T2W pulse sequence is characterized with score 2 and 3 in benign changes, and 4 and 5 in malignant changes using the PI RADS score system for differentiation. T2W pulse sequence combined with diffusion is a powerful tool for non-invasive differentiation of benign prostatic hyperplastic nodule and prostatitis from a malignant nodule.
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    Hypoplasiа of polygon of Willis
    (Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2012)
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    Zhivadinovik, Julija
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    Petrovska, Suncica
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    Jordanova, Olivera
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    Morphological characteristics of circulus arteriosus cerebri - Circle of Willis
    (Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2012)
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    Jordanova, Olivera
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    Waist circumference, waist-to-hip ratio cut-off points to predict obesity and metabolic syndrome among student population in skopje, North Macedonia
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2021-06-21)
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    Abdominal obesity is the most frequently observed component of metabolic syndrome. Any anthropometric measure is only the first step in identifying people at ‘early health risk’. This study aimed to determine a cut-off point of selected anthropometric indicators and to analyze the prevalence of normal weight obesity and abdominal obesity among university students. The study included 839 healthy students aged 18-20 (411 males and 428 females) from the Ss. Cyril and Methodius University in Skopje, R. North Macedonia. The following anthropometric parameters were measured: weight, height, two circumferences (waist WC and hip HC) using a standard protocol. The following indices were taken into consideration: Body Mass Index (BMI), WC and Waist-to-Hip Ratio (WHR). The prevalence of obesity across BMI cut-off points among Macedonian students was 22.22%. In the underweight group, the number of female students was significantly higher (12.61% vs 2.19%), while in the overweight and obesity group a higher percentage of male students was observed (27.5% vs 9.11% and 6.81% vs 1.41%). Prevalence of abdominal obesity according to WC and WHR cut-off among Macedonian students were: female had the prevalence of abdominal obesity (overweight and obese) of 25.47% WC and WHR 43.23%, respectively. Both cut-off points for the males were 34.55% WC and 52.81% WHR. However, the Macedonian cut-off points for WC and WHR showed a higher prevalence of abdominal obesity among males. These results and determination of BMI, WC, WHR cut-off values can be used for the prediction of consequences associated with obesity.
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    Sole patterns in some ethnic groups
    (Macedonian Association of Anatomists, 2021-04-02)
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    Populational dermatoglyphic study has been conducted in order to gain and compare data between different ethnic groups.The aims of the study is to establish analyze and compare individual dermatoglyphic features in healthy examinees of Macedonians, Albanians and Roma ethnic origin. In the current study some dermatoglyphic parameters were read on the right and left sole prints obtained from healthy individuals of Macedonian, Albanian and Roma ethnic origin.In each group sole prints were obtained from 100 males and 100 females. Sole prints were taken using Cummins and Midlo's ink method. Dermathoglyphics was classified and comparisment was made with results from other authors. We have found that most present patterns are found in the hallucal, first interdigital and distal thenar area on the sole, for both sexes. Second one according presence of the patterns is third interdigital area, with higher values in males compared to females, roma females with lowest values. Next is second interdigital configurational area on the sole, again higher pattern presence in males than females. Distal loops are most abundant pattern, followed by concentric whorls, rest of the patterns are present in lower percentage, for all groups and both sexes. For the present triradii the results are: d, c>b, a>pm>p>e>p’, p’’ in males and d>c>a, b>pm>p>e>p’>p’’ in females. The results, presented together with data on other dermatoglyphic features elaborated with other authors can serve as the basis of the dermatoglyphic status in healthy population with Macedonian, Albanian and Roma ethnic origin. They can also serve in further medico-biological investigation with theoretical and scientific purposes.