Faculty of Medicine

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    Metabolic Control and Pregnancy Outcome in Type 1, Type 2 and Gestational Diabetes Mallitus
    (Медицински факултет, Универзитет "Св. Кирил и Методиј", 2002)
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    Dzikov, Zlatan
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    Dimitrovski, Chedomir
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    Pop-Lazarova, Marina
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    Testicular size in our male population
    (Македонско лекарско друштво = Macedonian medical association, 1998)
    Dimitrovski, Chedomir
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    Sadikario, Samuel
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    Testicular size was measured in 800 healthy males ages 7 through 42. Testicular volumes were estimated by Prader's orchidometer. At chronological age 7-11 years, the normal mean testicular volume (MTV) ranged from 1.30 to 4.82cm³, and in 11-13 year old children 7.46 to 8.95cm³. It could mean that in our male population, puberty commences at 11-13 years of age. After 17 years of age, MTV was relatively stable and ranged from 18.25 to ±6,27cm³. Orchidometry could be useful in anthropological investigations and especially in routine clinical practice for evaluating the development of male puberty and andrological disorders.
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    Evaluation of diagnostic methods in decision making for surgery of adrenal incidentalomas
    (Македонско лекарско друштво = Macedonian medical association, 2003)
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    Dimitrovski, Chedomir
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    Popov, Zhivko
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    Insulinoma occultus - how to localize it topographically?
    (Македонско лекарско друштво = Macedonian medical association, 1998)
    Dimitrovski, Chedomir
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    Mirchevski, Jovan
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    Sadikario, Samuel
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    Peroxizomal dysfunction: cause of letal adreno-genital leukomyeloneuropathy
    (Македонско лекарско друштво = Macedonian medical association, 2001-01)
    Dimitrovski, Chedomir
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    Ljapchev, Risto
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    Dyslipidaemia and hypertension in patients with subclinical hypothyroidism
    (Macedonian Academy of Sciences and Arts/De Gruyter, 2009-12)
    Velkoska Nakova, Valentina
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    Dimitrovski, Chedomir
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    Serafimoski, Vladimir
    Objective: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with dyslipidaemia and arterial hypertension. Methods: At the Department of Endocrinology, Diabetes and Metabolic Disorders, Skopje, R. Macedonia, we examined 24 consecutive patients with SCH and 13 healthy controls in a period of 6 months. SCH was defined as an elevated thyrotropin (TSH) (> 4.2 mU/l) and normal free thyroxine (fT4) level (10.3-24.45 pmol/l). None of the patients had been previously treated with thyroxine. In all participants we determined blood pressure, body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidise (TPOabs), total lipids (TL), total cholesterol (TH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides. Results: Mean diastolic blood pressure increased in SCH patients vis-a-vis controls (85 vs. 74 mmHg; p < 0.05). Mean values of TL, TH, HDL-C, LDL-C, triglycerides, TC/HDL-C, and LDL-C/HDL-C were no different in patients with SCH compared with controls. Individual analysis revealed that the percentages of patients with SCH having arterial hypertension (29%), hypertriglyceridaemia (34.78%), elevated LDL-C (41.66%), elevated TC/HDL-C (21.7%), and LDL-C/HDL-C (21.74%) ratios were higher than the percentages in controls. No significant correlation between TSH and biochemical parameters was detected. Conclusion: Our study revealed that SCH patients have a greater prevalence of dyslipidaemia and arterial hypertension, and, as well, a greater value of mean diastolic pressure vs. control patients.
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    Association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus
    (Macedonian Academy of Sciences and Arts/De Gruyter, 2009-12)
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    Velkoska Nakova, Valentina
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    Adamova, Gordana
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    Dimitrovski, Chedomir
    Objective: The aim of the study was to investigate the association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus (GDM). Methods: The study group included 200 consecutive pregnant women who attended the Endocrinology, Diabetes and Metabolic Disorders Outpatient Department in the period from 02.2006 to 02.2009 with singleton pregnancy and GDM diagnosed following ADA criteria. The following parameters were studied: pre-pregnancy maternal body mass index (BMI), 3-hours 100g oral glucose tolerance test (OGTT) results, glycosylated haemoglobin (HbA1c), total lipids (TL), total cholesterol (TH), triglycerides (TG), HDL- and LDL-cholesterol levels at admission. Neonatal birth weight and the prevalence of being large for gestational age (LGA) was an end-point. Results: We found a significant association between birth weight and pre-pregnancy BMI, HDL-C and birth weight of a large child born previously. Birth weight of a large child born previously was the strongest independent predictor for LGA. The prevalence of LGA (from 27% to 80%) was related to a number of altered maternal characteristics. Conclusion: Pre-pregnancy BMI, HDL-C and birth weight of a large child born previously are the independent predictors for LGA, but results of glucose levels during OGTT are not useful in the prediction of LGA in GDM pregnancies. Probably more factors and other maternal metabolic parameters than glucose levels during OGTT are responsible for the risk of LGA.
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    Prevalence of thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes and diabetes type 1
    (Macedonian Academy of Sciences and Arts/De Gruyter, 2010-12)
    Velkoska Nakova, Valentina
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    Dimitrovski, Chedomir
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    The aim of the present study was to determine the prevalence of abnormal thyroid function and antithyroid antibodies during pregnancy in women with diabetes type 1 and gestational diabetes mellitus (GDM).
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    Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome
    (Macedonian Academy of Sciences and Arts, 2006-07)
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    Dimitrovski, Chedomir
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    Misevska, Sasha
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    Dimova, Zaneta
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    Laparoscopic Adrenalectomy: First Single-Center Experience in the Balkans
    (Walter de Gruyter GmbH, 2015)
    Popov, Zivko
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    Laparoscopic adrenalectomy has become the preferred approach for removal of the adrenal gland for the management of benign or malignant functioning or nonfunctioning adrenal masses. We aimed to present our initial experience with this procedure. In addition, we compare the clinical outcomes of laparoscopic (LA) vs. the open adrenalectomies (OA) performed at our institutions. Also we report a case of successful laparoscopic treatment of splenic artery aneurism involving laparoscopic splenectomy.