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Comparison of IFN-γ Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI)
(Scientific Foundation SPIROSKI, 2018-11-25)
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Simonovska, Liljana
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Dilberovska, Mirjana
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Dacevski, Dragan
This study aimed to evaluate the importance of IFN-γ in the diagnosis of pediatric TB and LTBI and to compare the IFN-γ levels.
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Role of Quantiferon TB gold test in diagnosis of latent tuberculosis infection(LTBI) in childhood and its correlation with tuberculin skin test
(Macedonian Association of Anatomists and Morphologists, 2015)
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Petrusevska Kolekevska, Lidija
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Dilberovska, Mirjana
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Dacevski, Dragan
Tuberculosis is a significant health problem among children population worldwide. Timely diagnosis and treatment of the disease are the basis for prevention of its further spreading. However, the diagnosis of latent tuberculosis infection is a challenge because there is no gold standard. The aim of this study was to evaluate the importance of the diagnostic Quantiferon TB gold test in the diagnosis of latent TB infection and to correlate it with Tuberculin skin test according to the Mantoux method. For the realization of this study we analyzed 32 patients examined for possible M. tuberculosis infection at the Institute of Respiratory Diseases in Children, Kozle, Skopje. The study included 16 girls and 16 boys, aged 9 months to 17 years, with an average age of 6.96 ± 4.49 years. In all children basic biochemical analyses were made: аcid-alcohol-resistant bacilli in a direct sample of sputum, Levenstein Jensen cultures, chest X-ray, tuberculin skin test according to the Mantoux method and Quantiferon TB gold test. The results showed that 24 patients had a BCG scar. All participants in this study had normal radiographic findings of the lungs. In 4 cases Quantiferon TB gold test was positive, while in 28 patients the test was negative. Tuberculin skin test was positive in 13 subjects. In children with negative Quantiferon TB gold test LTBI was excluded and drug prevention with Isoniazid was not started or it was interrupted. Determination of IFN-γ contributes to better diagnosis of LTBI and in reducing the unnecessary drug use. Using Quantiferon TB gold test may be an alternative tool for Tuberculin skin test in the diagnosis of tuberculosis in countries where vaccination with BCG is widespread.
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Etiology, epidemiology, clinical implications and treatment of acute bronchiolitis-a review of the literature
(Macedonian Association of Anatomists and Morphologists, 2013)
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Petrushevska-Kolekevska, Lidija
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Dilberovska, Mirjana
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Popova, Gorica
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Stevic, Valentina
Bronchiolitis is an acute viral infection that is one of the leading causes for hospitalization in young children. Despite the fact that etiology and clinical sings of the disease are well-known, in this article we will give summary of the latest scientific data related to the bronchiolitis. Bronchiolitis still remains an active field for research with many open questions still remains to be answered – ista recenica. Majority of bronchiolitis episodes are caused by respiratory syncytial virus and most often occur in children aged between two and 24 months. Most children get better with supportive care at home. A small number of children require hospitalization and treatment with oxygen and hydration.
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Comparison od IFN-γ levels in children with tuberculosis desease(TB) and latent tuberculosis infection (LTBI).
(ID Design Press,Skopje, Republic of Macedonia, 2018-11-25)
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Simonovska, Liljana
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Dilberovska, Mirjana
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Dacevski, Dragan
AIM: This study aimed to evaluate the importance of IFN-γ in the diagnosis of pediatric TB and LTBI and to compare the IFN-γ levels. METHODS: We analysed 100 patients examined for possible M. tuberculosis infection or disease at the Institute of Respiratory Diseases in Children, Kozle, Skopje. Patients were divided into 2 groups: TB disease and LTBI. The following parameters were analyzed: demographic characteristics, history of previous exposure to active TB, BCG vaccination and presence of BCG scar, lung X-ray findings, tuberculin skin test by the Monteux method and the value of INF-γ according to the Quantiferon TB gold test, direct samples of acid-alcohol-resistant bacilli of sputum and Löwenstein Jensen cultures. Informed parental consent was obtained for each child included in the study. RESULTS: In the LTBI group 60.9% had a scar from the vaccination while in the TB group 50% had BCG scar. TST induration diameters in children with or without BCG scar were significantly larger in patients with active TB. Children with active TB had significantly higher IFN-γ levels than children with LTBI. The IFN-γ for the cut-off of 0.35 IU/ml, has 64% sensitivity for detection of LTBI, versus 80.6% sensitivity for active disease. Children with close TB contact had significantly higher IFN-γ levels. Correlation between TST induration diameter and IFN-γ levels was stronger in the TB group. CONCLUSION: IFN-γ levels are significantly higher in children with active TB, and children with close contact with TB patient. It has better sensitivity in active TB. Using both tests (IFN-γ and TST) can improve the diagnose of LTBI and TB in countries where vaccination with BCG is widespread.

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