Faculty of Medicine

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Author: search.filters.author.Dabeski, Ana

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    Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix
    (Centre for Evaluation in Education and Science, 2019)
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    Dabeski, Ana
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    Trajanova, Milka
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    Todorovska, Irena
    Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.
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    High-risk HPV E6/E7 messenger RNA testing versus HPV DNA testing in women with squamous cell abnormalities of the uterine cervix
    (BMJ Publishing Group Ltd, International Gynecologic Cancer Society & European Society of Gynaecological Oncology, 2017-11)
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    Duvlis, Sotirija
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    Micevska, Megi
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    Dabeski, Ana
    Aims The study is performed in order to compare the results of two HPV screening methods: High-risk HPV E6/E7 mRNA and HPV DNA. Method Comparative prospective study, conducted in the period for April 2016 to March 2017 at the University Clinics for Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje and Institute of Public Health of Republic of Macedonia of 98 sexually active women, age groups of 20 to 60 years, with squamous cell abnormalities on the cervical cytology. In all 98 women were done: HPV DNA testing, High-risk HPV E6/E7 mRNA testing and colposcopy and directed biopsy with endocervical curettage for histopathological analysis. Results Histopathologically, there were: 36.7% non-neoplastic lesions, 20.4% LGSIL cases, 29.6% HGSIL cases and 13.3% invasive squamous cell carcinomas. HPV DNA was found 78.6% of the cases; E6 and E7 transcripts were found in 58.2%. The rates of detection of HPV DNA and E6 and E7 transcripts were 83.3% and 22.2% for cases with non-neoplastic finding; 65.0% and 45.0% for cases with LGSIL; 75.9% and 93.1% for cases with HGSIL and 92.3% and 100% for cases with invasive squamous cell carcinoma. High-risk HPV E6/E7 mRNA testing showed a higher sensitivity than the HPV DNA testing (79.0% and 75.8%), higher specificity (77.8% and 16.7%) and a higher positive predictive value for HGSIL ( 93.1% and 75.9%) and invasive squamous cell carcinoma (100% and 92.3%). Conclusion High-risk HPV E6/E7 mRNA testing could be more powerful than HPV DNA testing for screening and investigation of HGSIL and invasive squamous cell carcinoma.
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    Comparison Between HPV DNA Testing and HPV E6/E7 MRNA Testing in Women with Squamous Cell Abnormalities of the Uterine Cervix
    (Walter de Gruyter GmbH / MANU, 2019-05-01)
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    Duvlis, Sotirija
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    The aim of the study was to compare the results of two human papillomavirus (HPV) diagnostic techniques: human papillomavirus deoxyribonucleic acid (HPV DNA) testing and human papillomavirus E6/E7 messenger ribonucleic acid (HPV E6/E7 mRNA) testing in women with squamous cell abnormalities of the uterine cervix.