Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
8 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chemical ablation as successful alternative for treatment of incompetent perforators(Македонско лекарско друштво = Macedonian medical association, 2023-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute bacterial meningitis – challenges and conclusions(IMAB Peytchinski Publishing Ltd., 2024-10); ; ; Acute bacterial meningitis is an urgent condition characterized by significant morbidity and mortality. In the last decades, epidemiology of the most common etiologic agents as well as the age limit has changed significantly, with dominant involvement of the adult population and population at risk. Streptococcus pneumoniae remains the most common bacteria causing bacterial meningitis. The aim of this study is to observe the changes in the prevalence of etiologic agents and their dominance, the most commonly affected age groups, as well as comorbidities and complications in patients with acute bacterial meningitis treated at the University Clinic for Infectious Diseases in Skopje, R.N. Macedonia. In the last seven-year period, 194 patients with acute bacterial meningitis were treated. The etiologic agent in cerebrospinal fluid was confirmed in 94 (48.45%) patients, with the predominance of S. pneumoniae in 74 (78.72%). L. monocytogenes with 10 (10.63%) and N. meningitides with 6 (6.38%) were less represented. Male sex is dominant with 111 (57.21%) and older age groups as well. More than half of the patients, from the study, belonged to the at risk population with the highest percentage of them presenting with more than two comorbidities, as well as complications. In our study group, 41 (21.13%) of the patients died. Because of the substantial mortality and morbidity, it remains an urgent need to optimally deploy existing vaccines worldwide and develop new prevention strategies and treatment options. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pneumonia impact on the flow and the outcome at patients with seasonal influenza(European Respiratory Society, 2020-09); ; ; ; Abstract Seasonal influenza complications are the cause of development of severe clinical picture as well as death. The most common are the respiratory ones, and the leading one that stands out is the secondary bacterial pneumonia. The aim of this study is determining the pneumonia impact on the severity of the clinical picture as well as the outcome for the patients with influenza. The research is prospectively compared in groups, carried out at University Clinic for Infectious Diseases during a 3-year period. 122 adult patients with clinical and laboratory confirmed influenza have been analyzed. Based on the severity of the clinical picture, patients were divided into two groups, a severe (n=87) and a mild (n=35) form of the disease. During the study demographic, general data, clinical symptoms and signs as well as complications have been recorded. Out of 122 patients with influenza, there were registered complications at 108 (88.52%), with significant appearance in the group with severe influenza 93.1% vs 77.14% (p=0.012). The most common one in percentage is pneumonia 98(80.33%) which also significantly influenced the severity of the disease (p=0.002). Complications such as ABI 8(6.56%), ARDS 7(5.74%), sepsis 5(4.1%), DIC 4(3.28%), and otitis 2(1.64%) have been registered only in the group with severe influenza. At 5(4.1%) patients acute meningoencephalitis has been registered, gastroenterocolitis at 3(2.46%), an hepatic damage at 14(11.47%) of the patients. Pneumonia as the most common complication for patients with severe influenza has significant impact on the clinical flow ant the outcome of the disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Seasonal influenza-factors associated with a severe clinical form of the illness.(Македонско лекарско друштво = Macedonian Medical Association, 2016); ; ; ; Kirova Urosevic V - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Covid-19 pneumonia associated with rhabdomyolysis in patient with previous chronic therapy with statin: coincidence or realted conditions?(Macedonian Association of Anatomists, 2021-03); ; ; Taseva Bogoeva Suncica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SAPS 2 score valid parameter for outcome in severe influenza(Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, R Macedonia, 2021); ; ; ; Cvetanovski, Vlatko - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Factors Associated with Lethal Outcome in Patients with Severe Form of Influenza(Macedonian Academy of Sciences and Arts/Sciendo, 2016-11-01); ; ; Cvetanovski, VlatkoIntroduction: Clinical manifestations of influenza range from relatively mild and self-limiting respiratory infections to severe clinical manifestations with significant morbidity and mortality. The awareness of predictive indicators for the lethal outcome of influenza is of particular significance in making timely and exact decision for adequate treatment. The aim of this study was to identify the factors in patients with a severe form of influenza, resulting in lethal outcome. Materials and methods: The investigation was a prospective group comparison conducted at the University Clinic for Infectious Diseases in Skopje, R. Macedonia in the period from January 01, 2012 to January 01, 2015. The study included adult patients with a severe form of influenza who were further categorized into a group of either survived patients or a group of deceased patients. Demographic, clinical and biochemical data were noted in all patients included in the study on admission. The variables of the univariate analysis that showed a significant difference in terms of the outcome were used for creating multivariate logistic and regression analysis of the outcome as dependent factors. The independent predictors for lethal outcome in severe cases of influenza were identified by using logistic regression. Results: The study included 87 patients with a severe form of clinical and laboratory confirmed influenza. The patients were divided in two groups: survived (n = 75) and deceased (n = 75). The overall mortality was 13.79%. Multivariate analysis conducted on admission to hospital identified cardiovascular comorbid diseases (p = 0.014), urea values higher than 8.3 U/L (p = 0.045) and SAPS score (p = 0.048) as independent predictors of the outcome in patients with severe form of influenza. Influenza patients with cardiovascular diseases had 2.024 times greater risk of death from influenza in comparison to the patients having influenza without history of such a disease (OR = 2.024 95% CI 1.842-17.337). Patients with serum urea values higher than 8.3 U/L had 1.89 times higher chance of death compared to patients with normal values (OR = 1.89 95% CI 1.091-11.432). The increase of the SAPS score in one point increased the chance of death in patients with influenza by 1.2% (OR = 1.12 95% CI 1.01-2.976). The ROC analysis indicated that cardiovascular diseases, increased urea values and SAPS score in combination act as a good prognostic model for the fatal outcome. The global authenticity of this predictive model to foresee lethal outcome amounts to 80%, sensitivity being 82%, and specificity 70%. Conclusion: Cardiovascular diseases, increased values of urea over 8.3 mmol/l and SAPS score are independent predictive indicators for lethal outcome in severe influenza. Early identification of the outcome predictors in patients with severe influenza will allow implementation of adequate medical treatment and will contribute to decreasing of mortality in patients with severe form of influenza. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Impact of Pneumonia on the Course and Outcome in Patients with Seasonal Influzenza(Macedonian Academy of Sciences and Arts/Sciendo, 2020-09-01); ; ; ; Introduction: Seasonal influenza, although often presented as a mild, self-limiting disease, is frequently accompanied by complications that lead to the development of a severe clinical presentation and a fatal outcome. The most common are respiratory complications, with secondary bacterial pneumonia being the leading cause. Aim: The aim of this study is to determine the impact of pneumonia on the severity of the clinical presentation and outcome in patients with seasonal influenza. Materials and methods: This research is comparatively group-based and has been conducted at the University Clinic for Infectious Diseases and Febrile Conditions during a three-year period. The analysis consists of 122 adult patients with clinically and laboratory-confirmed influenza. Based on the severity of the clinical picture, the patients are divided into two groups, severe (n=87) and mild (n=35) forms of the disease. The study included demographic, general data, clinical symptoms, and signs as well as complications. Results: Of 122 patients with seasonal influenza, complications were registered among 108(88.52%), with a significantly more frequent emergence among the group with severe influenza 93.1% vs 77.14% (p=0.012). Pneumonia was the most common 98(80.33%) and had a significant effect on disease severity (p=0.002). Complications from the types of ABI 8(6.56%), ARDS 7(5.74%), sepsis 5(4.1%), DIC 4 (3.28%) and otitis 2(1.64%) were reported only in the group with severe influenza. Acute meningoencephalitis was registered among 5(4.1%), gastroenterocolitis among 3(2.46%), and hepatic damage among 14(11.47%) of patients. Conclusion: Pneumonia as the most common complication among patients with seasonal influenza significantly impacts the clinical course and outcome of the illness.