Faculty of Medicine
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Item type:Publication, BRIEF REVIEW OF THE THROMBOTIC CEREBROVASCULAR COMPLICATIONS ASSOCIATED WITH NONSTEROID ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH CEREBROVASCULAR DISEASES(Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2023); ; ; Introduction. The use of the commonly used non-steroid anti-inflammatory medications can lead to specific complications in patients with cerebrovascular conditions. Their safety profile can be associated with both hemorrhagic and thrombotic complications, which can exert untoward influence in these patients. The aim of the present text is to 1) meaningfully recapture the main literature findings on the thrombotic complications due to use of NSAIDs in these patients and to 2) provide aid for physicians that encounter such decisions. Inhibition of the cyclo-oxygenase as main effect. The use of these medications rely on a common mechanism that inhibits a specific set of enzymes called cyclooxygenase inhibitors. Here, we revisit the specific cascade that enables their effect and the important interplay that may occur in patients with cerebrovascular diseases, including medications that exert unspecific vs targeted inhibition of those specific enzymes. Conclusion. The use of particular NSAIDs have been evaluated in patients with cerebrovascular diseases, and their specific risk for thrombotic complications in these patients have been examined in wide collection of patients. So far, these evaluations emphasize the association between the duration of use and type of selectivity of a particular NSAID and its risk for further thrombotic complications. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effectiveness after immunization with BNT162b2 and Gam-COVID-Vac for SARS-CoV-2 and neutralizing antibody titers in health care workers(Walter de Gruyter GmbH, 2024-05-24); ; Ajeti, ValdrinaObjectives The aim of this study was to describe the effectiveness of the vaccines (Tozinameran and Sputnik V), administered on a convenience sample of healthcare workers, and also to describe the relationship between the levels of neutralizing antibodies (NAbs) and the type of vaccine used, as well as their association with incident cases during follow-up. Methods The study included 262 participants, who underwent vaccination during the period from September 2021 until August 2022. For determining the levels of NAbs we used the CLIA based method, and all the samples were processed with the SNIBE Maglumi 800 analyzer. The patients were observed for one year for occurrence of incident infection. Results The participants with prior SARS-CoV-2 positivity showed substantially higher titer of NAbs (8.86 vs. 0.94, p<0.001). The participants in the Gam-COVID-Vac group had median levels of NAbs of 1.57 (IQR 0.42–5.73), while they in the Tozinameran group showed substantially higher levels of 2.37 (IQR 0.9–6.27). The incident cases after immunization had substantially lower median values of NAbs when compared to the rest (0.48 vs. 3.97, p<0.001), and the interval between the second dose and the serological measurements were similar. Conclusions The current study showed that the tested vaccines demonstrated vaccine effectiveness of over 50 % during the first year after the vaccination in a sample of health care workers. Although health care workers remain separate population group, when compared to the rest, the results could be extrapolated to populations with similar age and immune experience. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diabetes and arterial stiffness, our experiences(Македонско лекарско друштво = Macedonian medical association, 2021); ; Introduction. The incidence and prevalence of diabetes mellitus (DM) has increased worldwide but also in the Republic of Macedonia, Diabetes is a high-ranking a cause of death, primarily as a cause of cardiovascular death. In the United States, 42% of diabetic patients have diabetic nephropathy, with a 20-fold increased risk of cardiovascular mortality. Arterial rigidity is another independent risk factor for CV death, which is a degenerative process of remodeling the large arteries wall. There is increased arterial rigidity in both: diabetic patients and in patients with arterial hypertension, but studies that address these issues do not have consistency in the results, which was our motive for this study. Methods. This was a cross-sectional study that comprised 62 patients with diabetes mellitus type 2, aged over 38 years, followed at the University Clinic for Nephrology for diagnosis of, or already diagnosed hypertension. The control group consisted of 22 healthy subjects who had not been diagnosed with either DM type 2 or arterial hypertension. We examined pulse wave velocity, and analyzed hypertension with data obtained from 24-hour ambulatory blood pressure monitoring. The obtained data were statistically processed. Results. The results were displayed in tables. Conclusion. Arterial stiffness (measured by PWV) was higher in patients with DM compared to the control group of healthy subjects. In our study HgA1c had impact on PWV which can serve as a tool for assessing CV risk and arterial rigidity. Keywords: diabetes mellitus, arterial hypertension, arterial rigidity, pulse wave velocity - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECTS OF RAMADAN FASTING ON SOME BIOCHEMICAL PARAMETERS(Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, 2021); ; ; Petrushevska-Stanojevska, ElenaIntroduction: Holy month Ramadan lasts for about 29-30 days. It is mandatory for all adult individuals of the Islamic faith to fast during the holy month of Ramadan. During this period, healthy Muslims do not eat or drink (i.e., total abstinence from food and fluids) and refrain from tobacco, daily from pre-dawn until dusk. Materials and Methods: The present study included healthy adult male and female Muslim volunteers from different towns in the Republic of North Macedonia. The number of subjects in the study was 195. Blood samples from all subjects were collected twice during the study - once 2-3 days prior to the beginning of Ramadan and then again, the last day of Ramadan fasting. The following biochemical parameters were taken into consideration: total cholesterol, triglycerides, HDL cholesterol, glucose, insulin, total proteins, albumin, total and direct bilirubin, urea, creatinine and uric acid. Results: It was observed that compared to pre-fasting levels, total cholesterol (TC) and triglycerides (TG) were significantly decreased (P=0.000) and high-density lipoprotein cholesterol (HDL-C) level had significantly increased (P=0.000); total proteins were significantly increased (P=0.000); albumins were significantly increased (P=0.004); urea was significantly increased (P=0.004); total and direct bilirubin were significantly increased (P=0.000), glucose was significantly increased (P=0.000); there was no change in insulin levels (P<0.1) Conclusion: This study showed that Ramadan fasting has an effect on biochemical parameters. We can conclude that reduction in total cholesterol and triglycerides along with a rise in levels of HDL-C have beneficial effects on lipid profile post-Ramadan fasting period.