Faculty of Medicine

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Author: search.filters.author.Bushinoska J

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    Neonatal mortality rate at Gynecology and Obstetrics Clinic in Skopje in the period of five years in newborns treated at Neonatal Intensive Care Unit
    ("Ss. Cyril and Methodius" University, Faculty of Medicine, Department of Anaesthesia and Reanimation, 2020-10)
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    Bushinoska J
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    Orovcanec N
    Introduction: Neonatal mortality is a number of neonatal deaths per 1,000 live births in a given year or period. Neonatal mortality is defned as a death in the frst 28 days of life or a neonatal period after delivery. It includes all life born neonates after 22 gestational week of pregnancy and with birth weight over 500 g. Neonatal mortality is divided into early neonatal mortality which count deaths in 0-7 days after delivery, and late neonatal mortality 8-28 days after delivery. AIM: The aim of the study is to present hospital neonatal mortality rate at the GOC-Skopje, among newborns treated at NICU in the neonatal period of 0-28 days after births, in the period of fve years 2013-2017 and to determinate the leading causes of neonatal deaths at NICU. Material and Methods: Retrospective study counts neonatal mortality rate in the early and late neonatal period, as well as the leading causes for neonatal deaths in neonatal period of 0-28 days after delivery at the GOC-Skopje, in the period of 5 years. The data is collected from the Data basis of NICU at GOC-Skopje. Results: Hospital neonatal mortality rate in the 5 years period was 25.6‰, or 25.6 neonatal deaths in the neonatal period. There were 688 neonatal deaths on 26,891 live-born neonates. Neonatal mortality rate in early neonatal period (0-7 days) is – 547 or 20.34‰ of all neonatal deaths in the fve years period. Late neonatal mortality (8-28 days) after delivery was in 141 casesor 5.24‰. The leading causes for neonatal death in newborns treated at NICU were com plications due to prematurity, respiratory distress syndrome and neonatal sepsis. Conclusion: The hospital neonatal mortality rate at GOC-Skopje in fve years period is high, and requires more prospective studies and strategies to reduce neonatal mortality in the future.
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    CORRELATION BETWEEN HER2 AND EBV EXPRESSION IN GASTRIC CARCINOMA
    (Macedonian Association of Anatomists, 2020)
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    Bushinoska J
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    Hadzi-Mancev D
    Introduction: The understanding of the etiopathogenesis and the molecular basis of gastric carcinoma will facilitate the development of novel molecular target therapies, which interfere with different signal cascades involved in cellular proliferation, differentiation and survival. The aim of this paper was to determine the correlation between HER2 and EBV expression in patients with gastric carcinomas. Material and methods: Eighty patients with gastric carcinoma surgically treated were included in the study. Data of HER2 protein expression were obtained from the archived histopathological reports of the Institute of Pathology in Skopje. For detection of EBV, immunostainings were performed on tumor tissue and the peripheral nontumor gastric mucosa. Results: The results of this study confirmed a significant association between HER2 and EBV expression (p=0.041). The value of the Spearman correlation coefficient (R = - 0.258) indicated a negative, indirect connection of HER2 and EBV expression, which was confirmed as statistically significant (p = 0.02). The HER2 expression in gastric carcinomas was significantly associated with EBV expression, and the expression of HER2 was significantly more common in EBV negative cancers.
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    DEMOGRAPHIC AND PATHOLOGICAL CHARACTERISTICS OF GASTRIC CARCINOMAS – A Three-Year Single Center Experience
    (Macedonian Association of Anatomists, 2020)
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    Trajkovski G
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    Bushinoska J
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    Nikolova D
    Introduction: Despite the decline in incidence and mortality rate in recent years, gastric carcinoma (GC) remains one of the leading causes of cancer-related deaths worldwide, especially in developing countries. The aim of this study was to present the clinical and pathological characteristics of gastric carcinomas in patients from R. North Macedonia. Material and methods: One hundred and forty-nine patients with gastric carcinoma were included in the study. Sixty-one patients underwent subtotal gastric resection with lymphadenectomy, and 88 patients underwent total gastrectomy with lymphadenectomy. Tumor localization, TNM classification, grade and stage were determined for each patient. The parameters of the TNM classification (AJCC Cancer Staging 2017) were obtained from the archived histopathological reports of the Institute of Pathology in Skopje, and for the clinical stage patients’ files from the University Clinic for Abdominal Surgery in Skopje were used. Results:The most common intragastric location of gastric carcinomas was cardia in 61 (40.94%) patients, followed by antral/pyloric carcinoma location in 51 (34.23%) patients and corpus location in 37 (24.83%) patients. According to the T status (local tumor growth), more than half of the examined patients 84 (56.38%) were in T4 status of the disease. Presence of positive regional lymph nodes was detected in 113 (75.84) patients, and negative in 36 (24.16%) patients. The majority of patients that comprised the analyzed group - 81 (54.36%) had a poor differentiated gastric carcinoma, and 88 (59.06%) were in Stage III of the disease.