Faculty of Medicine

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Author: search.filters.author.Banović, PavleHas files: Yes

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    Current Status and Challenges Associated with Tick-Borne Pathogens and Diseases: Where Do We Stand?
    (MDPI AG, 2023-10-23)
    Banović, Pavle
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    Rodríguez, Islay
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    Lyme Borreliosis (LB), caused by Borrelia burgdorferi sensu lato (s.l.) and transmitted by specific Ixodes spp. ticks, is the most common vector-borne disease in the United States and the most common tick-borne disease in the northern hemisphere [1,2]. Despite accepted guidelines for diagnosing LB, with specific clinical case definitions, in the absence of relevant clinical information or when faced with an atypical presentation, clinicians tend to rely on serological tests when including LB in the differential diagnosis. Serological tests for LB, conducted in accordance with the European Concerted Action on LB guidelines as part of a two-stage diagnostic process, frequently pose challenges in interpretation, especially with nonspecific clinical presentations. This is primarily attributed to the significant occurrence of false-positive results, which can be influenced by cross-reactivity with acute viral infections [3]. In this Special Issue, Wojciechowska-Koszko et al. [4] confirm that serological tests used in the diagnosis of LB can generate false-positive results in patients with acute viral infections. More precisely, tests used for the first step of the two-stage approach, such as enzyme-linked immunosorbent (ELISA) or indirect immunofluorescence (IIFT), and the immunoblot (IB) method for the second step of the two-stage diagnostic approach all showed significant cross-reactivity and positive results in patients with Epstein–Barr virus (EBV), cytomegalovirus (CMV), and BK virus (BKV) infections without clinical manifestations related to LB.
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    Cases of Crimean-Congo haemorrhagic fever in North Macedonia, July to August 2023
    (European Centre for Disease Prevention and Control, 2023-08)
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    Rangelov, Goran
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    Pavleva, Verica
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    Banović, Pavle
    The last report of Crimean-Congo haemorrhagic fever (CCHF) in North Macedonia was more than 50 years ago in the northwest. We report on a fatal CCHF case following a Hyalomma tick bite in the east of the country in July 2023. Tracing of 67 contacts identified CCHF in one healthcare worker (HCW) providing care for the patient. Monitoring of contacts is concluded (including further 11 HCW contacts), thus far 28 days after the death of the case no additional cases were identified.
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    Mediterranean spotted fever-like illness caused by Rickettsia sibirica mongolitimonae, North Macedonia, June 2022
    (2022-10-20)
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    Mateska, Sofija
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    Simin, Verica
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    Bogdan, Ivana
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    Mijatović, Dragana
    Mediterranean spotted fever-like illness (MSF-like illness) is a tick-borne disease caused by Rickettsia sibirica mongolitimonae first reported in France more than 25 years ago. Until today, more than 50 cases of MSF-like illness have been reported in different regions of Europe and Africa, highlighting variable clinical manifestation. Here we report a case of MSF-like illness following a bite from a Hyalomma tick in the Skopje region of North Macedonia.