Faculty of Medicine

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    Pitfalls, Myths, and Errors in Pulse Oximetry: Understanding False Readings in Severe Hypoxemia
    (ECRONICON open acesss, 2025-03-13)
    Avramovska, Maja
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    Nikleski, Zorica
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    Siklovska, Vesna
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    Todorovska, Liljana
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    Pulse oximetry is a widely used, non-invasive method for monitoring oxygen saturation (SpO2) in clinical and specialized settings, including maritime and high-altitude medicine. However, several pitfalls and misconceptions can lead to false readings, particularly in cases of severe hypoxemia. This mini-review explores the limitations of pulse oximetry, the role of perfusion index (PI) in assessing peripheral circulation, and common sources of measurement errors, such as low perfusion states, motion artifacts, and skin pigmentation. The clinical interpretation of SpO2 levels is discussed, emphasizing the need for caution when readings fall below 65%, where peripheral cyanosis is evident, rendering further saturation assessment redundant. Additionally, a nomogram illustrating the relationship between SpO2, partial pressure of oxygen (PaO2), pH, and PaCO2 is presented, aiding in the understanding of respiratory acidosis and alkalosis. The review also highlights the importance of SpO2 monitoring in critical conditions, including cytokine storm syndromes, and discusses the integration of Bluetooth-enabled pulse oximeters for real-time data transmission. Understanding the limitations and proper interpretation of SpO2 readings is crucial for avoiding misdiagnosis and ensuring accurate clinical decision-making.
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    Inflamed Mesenteric Pseudocyst Associated with Meckel’s Diverticulitis: Cause or Consequence
    (Knowledge E DMCC, 2024-12-08)
    Talev, Stefan
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    Avramovska, Maja
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    Avramovski, Petar
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    Nikleski, Zorica
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    Ivkovska, Tamara
    Introduction: Mesenteric pseudocyst describes an abdominal mass that appears on small bowel mesentery or mesocolon, or at any part of the abdomen and retroperitoneum. This paper aims to emphasize the non-specific clinical appearance and highlight Meckel’s diverticulitis as a potential cause of the development of pseudocyst. Case Report: A 26-year-old male with a palpable mass in the right upper abdominal quadrant and an increased body temperature of 38.3∘C was admitted for further medical investigation. Computed tomography (CT) presented a cystic mass with a diameter of 5.5 cm, and emergency laparotomy was performed. Wedge resection of pathologic findings of small bowel, its mesenterium, and the cyst mass associated with nearby Meckel’s diverticulum was performed. Discussion: Meckel’s diverticulum can be considered as a risk for developing mesenteric pseudocyst, because of its frequent exacerbation of chronic inflammation. This report adds to the limited literature on the association between Meckel’s diverticulum and mesenteric pseudocysts, providing valuable insights that can guide future clinical evaluations and surgical interventions. Early and accurate diagnosis, aided by imaging techniques such as CT and magnetic resonance imaging (MRI), is essential for effective management. This case highlights the potential link between chronic inflammation in Meckel’s diverticulum and the formation of mesenteric pseudocysts. Conclusion: This case highlights the need to consider Meckel’s diverticulitis in patients with mesenteric pseudocysts, suggesting a possible pathophysiological link between them. Surgical resection is recommended for effective management.
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    The Gamma Gap Predicts All-Cause Mortality in Chronic Dialysis Patients
    (2021)
    Avramovski, Petar
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    Avramovska, Maja
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    Ilkovska, Biljana
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    Sotiroski, Kosta
    The gamma gap (γ-gap) represents the total serum protein concentration minus the albumin concentration. The main aim of this study was to test whether the gamma gap is a predictor of mortality and whether it is associated with other predictors of mortality in chronic hemodialysis patients (CHPs).