Faculty of Medicine

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Author: search.filters.author.Arsovski, Andreja

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    Chemical ablation as successful alternative for treatment of incompetent perforators
    (Македонско лекарско друштво = Macedonian medical association, 2023-12)
    Cvetanovski, Vlatko
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    Cimjescikj, Dina
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    Arsovski, Andreja
    ;
    Mitevski, Aleksandar
    Introduction. Superficial venous incompetence (SVI) is the most common cause of lower extremity superficial venous reflux and varicose veins; nonetheless, incompetent perforator veins (PVs) are the most common cause of recurrent varicose veins after treatment, often unrecognized. Current minimally invasive treatment options include ultrasound-guided sclerotherapy (USGS), endovascular thermal ablation (EVTA) with either laser or radiofrequency energy sources, subfascial endoscopic perforator surgery (SEPS) and the relatively new chemical ablation procedure using cyanoacrylate adhesive, which we chose as our primary treatment option for this study, using and comparing the results of two different adhesives. Methods. A retrospective review of a prospectively managed database of chemical ablation as perforator vein treatment performed at a single institution from September 2023 to March 2024 was conducted. The indications for PV treatment were >4 mm in diameter and reflux of >500 milliseconds upon leg compression. Results. A total of 32 patients and 49 limbs presenting PV insufficiency (coexisting with GSV insufficiency in 19 patients) were divided into 2 groups of 16 patients, each group based on the chosen chemical ablation adhesive - VenaBlock and VenaSeal. The VenaBlock group had PV closure rate of 100% immediately intraoperative, at 3 days, 2 weeks, 3 weeks and 1 month from the procedure for each treater perforator. From the VenaSeal group, 13 patients had immediate and continuous treatment success during the follow-up, while in 3 patients there was intraoperatively registered treatment failure (P=0.0127). Conclusion. We find the chemical ablation procedure to be safe and effective for PVs, specifically in the case of using rapid polymerization adhesive. Due to its simplicity and short procedural time, we consider this to be the procedure of choice in case of multiple incompetent PVs present, as well as in significant PV tortuosity.
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    RHINOMANOMETRY AS A METHOD FOR OBJECTIFICATION OF NASAL AIR RESISTANCE IN SELECTING PATIENTS FOR SEPTORHINOPLASTY
    (Македонско лекарско друштво = Macedonian medical association, 2019)
    Petreska-Dukovska, Vesna
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    Arsovski, Andreja
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    Orovchanec, Gjorgji
    Abstract Aim of the study. To objectify the nasal air resistance (nasal obstruction) using rhinomanometry while selecting patients for septorhinoplasty. Methods. This is a prospective, non-randomized study which compriseda totalof 100 patients experiencing deviations of the nasal septum (deviatioseptinasi) aloneor along with deformities of the nasal pyramid: rhinokyphosis, rhinoscoliosis, rhinolordosis (“saddle nose”), and “functional tension nose”. The examined patients were added to the list for surgical septo/rhinoplasty procedures performed at the ENT Clinic at the University Hospital Center in Skopje and the General Hospital "Remedika", during the period of 2014-2019. The rhinomanometry examinations were performed at the General Hospital "Remedika" in Skopje.The examined groups were divided according to several parameters.Based on the degree of nasal obstruction, patients were divided into 3 groups:Group IA had a severe degree of nasal obstruction (severe degree of nasal resistance); Group IB had a moderate degree of nasal obstruction (moderate degree of nasal resistance); Group II had a mild degree of nasal obstruction (mild degree of nasal resistance), and this group was clinically monitored for a year when a decision was made onperforming a surgical intervention. Results. Despite dividing patients into three groups and the one-year follow-uppeiodofpatients with a mild degree of nasal obstruction, all patients underwent septoplasty. The results obtained enabled us to differentiate and grouppatients who were truly in need of septo/rhinoplasty and patients whowere to be monitored and treated with medication. Conclusion. Rhinomanometry allows classification of patients forurgent intervention according to the results on the degree of nasal obstruction as well as the degree of nasal symptomatology.
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    BRCA1 and BRCA2 germline variants in breast cancer patients from the Republic of Macedonia
    (Springer Science and Business Media LLC, 2018-04)
    Jakimovska, Milena
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    Maleva Kostovska, Ivana
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    Popovska-Jankovic, Katerina
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    Kubelka-Sabit, Katerina
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    Karadjozov, Mitko
    We aimed to establish the spectrum of BRCA1/2 mutations among the breast cancer (BC) patients from the Republic of Macedonia.