Faculty of Medicine

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    Item type:Publication,
    Optimizing Nephrectomy Outcomes through 3D-Printed Anatomical Replicas
    (Macedonian Medical Association, 2024-04)
    Arsenkov, Stefan
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    Arsenkov, Emilija
    The utilization of 3D-printed replicas of patient-specific anatomy represents a significant advancement in the field of surgical planning. This abstract discusses the methodology, benefits, and implications of employing 3D-printed models in the preoperative planning and intraoperative phases of complex surgeries. The process begins with acquiring high-resolution images using CT or MRI. These images are then converted into a digital 3D model, which is used to produce a detailed physical replica of the patient's anatomy using 3D printing. The primary advantage of this approach is the ability to enhance the surgeon's understanding of the tumor's size, location, and relationship with adjacent structures. By physically manipulating the 3D model, surgeons can strategize the most effective surgical approaches, anticipate challenges, and avoid complications. Furthermore, these replicas can be used for patient education, improving their understanding of the procedure and setting realistic expectations. Clinical outcomes have shown the use of 3D-printed models for surgery planning can lead to shorter operation times and reduced intraoperative blood loss. We present the case of a 58-year-old female patient requiring a nephrectomy due to a large tumor of the left kidney. A 3D-printed anatomical replica was used for preoperative planning with promising results. The postoperative histological examination revealed the renal mass was a clear cell carcinoma of the kidney. Additionally, 13 lymph nodes were extracted, none showing signs of metastatic alteration. This not only demonstrates the surgical team's thoroughness but also highlights the added value of the 3D model in enabling meticulous dissection and evaluation of surrounding lymphatic tissue. In conclusion, the integration of 3D-printed anatomical replicas into the surgical workflow for large kidney tumors offers a tangible improvement in preoperative planning, surgical precision, and patient outcomes. As this technology becomes more accessible, it is poised to become a standard tool in the surgical treatment of renal pathologies.
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    Bilateral near-total calcification of vas deferens in young male
    (Macedonian Medical Association, 2024-04)
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    Arsenkov, Stefan
    Bilateral calcification of vas deferens is an uncommon condition, particularly in young males. Only a few case reports are published for this condition in young males, and what they have in common is diabetes mellitus. A 33-year old man presented with dull pain in the right inguinal region. The patient has had history of insulin dependent diabetes mellitus type I for thirty years. He complained of dull pain in the right inguinal region. The pain started about ten years ago, but it has grown stronger and more frequent in the last two months. CT scan was performed which confirmed the presence of calcification along almost the entire length of the vas deferens, starting from testes to the prostate with prostatic calcification. Androflor Screen test was made to detect the total bacterial DNA, and pathological levels of Bacteroides spp./Porphyromaonas spp./Prevotella spp. were detected and antibiotic treatment was prescribed. Calcification of the vas deferens is relatively specific to DM and 70% of males who had vas calcification also had diabetes. There are other etiologies associated with the calcification of vas deferens such as chronic infections and inflammations, but it can also be seen as a manifestation of aging. The calcification may also be associated with infertility. Pathologically, diabetic vas deferens calcification can be differentiated from the chronic inflammatory type. Chronic inflammatory calcification is usually intraluminal which may be unilateral and segmental, while the calcification seen in diabetes is usually mural and symmetrical. Unfortunately, currently there are no available curative treatment option for this condition. Diabetes is the primary cause of bilateral calcification of the vas deferens in young males, which can lead to infertility. Bearing this in mind, it's important to inform patients about the associated risks and advise them to take necessary precautions.
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    3D Printing for Preoperative Planning in Pancreatic Resection for Rare Metastasis from Ovarian Cancer: a case report
    (Research Square Platform LLC, 2024-04-02)
    Arsenkov, Stefan
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    Plavevski, Ognen
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    Arsenkov, Emilija
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    Secondary pancreatic malignancies are a rarely reported entity, limited to sporadic case reports in the medical literature. Most often, these secondary malignancies are of renal origin, followed by gastrointestinal tumors and lung cancer as the primary tumor sites. Metastatic tumors from ovarian origin are few and far between. In our understanding this is the first time 3D printing has been used in the preoperative planning of one such case. Case presentation We present the case of a 63 year old patient with a history for bilateral ovariectomy for ovarian tumor 5 years prior, with a 3D printed model of the patient’s anatomy used for preoperative planning as a novel approach. During regular check-ups, an elevated CA19-9 level prompted a CT scan showing a distal pancreatic mass entering the splenic hilum, and a PET scan showed FDG avid lesion considered malignant and no other lesions were detected. The location of the metastasis warranted a distal pancreatectomy with splenectomy. To aid in the preoperative planning a 1:1 replica of the patient’s anatomy was constructed based on the CT scan, and it was manufactured using 3D printing. After extirpation of the tumor, the histological analysis showed a pancreatic pseudocyst with an intraluminal neoplastic proliferation, and further immunohistochemistry analysis determined the immunophenotype suitable of an ovarian cystadenocarcinoma metastasizing to the pancreas. Conclusions The surgical team was unanimous in the impression that the 3D printed model facilitated a swift surgery without any complications. Not only the model helped the planning phase, it is useful as a tool for patient education and further education of students and residents.</jats:p>
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    Item type:Publication,
    Enhancing surgical planning of distal splenopancreatectomy through 3D printed models: a case report
    (Oxford University Press (OUP), 2023-09)
    Arsenkov, Stefan
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    Plavevski, Ognen
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    Arsenkov, Ljuben
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    Shurlani, Arben
    <jats:title>Abstract</jats:title> <jats:p>The complex anatomy of the peripancreatic region was a challenge to many surgeons in the past. Up until recently, the only way to prepare and plan a surgery was through the use of traditional 2D images, obtained via computed tomography or magnetic resonance imaging. Recently, the advantages in the field of 3D printing (also called additive manufacturing, or rapid prototyping) allowed the creation of replicas of the patient’s anatomy which is to be used for preoperative planning and visual reference. We present the case of a 46-y.o. patient with a distal pancreatic lesion requiring a distal splenopancreatectomy, who benefited from the use of 3D printing technology. No intraoperative or postoperative complications were encountered, while the created model was used to plan and perform the needed resection.</jats:p>