Faculty of Medicine
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Item type:Publication, Chronic lymphocytic leukemia following successfull treatment of Hodgkin’s lymphoma: report of two patients(Македонско лекарско друштво = Macedonian Medical Association, 2017); ; ; ; Arif LatifiOver the past few decades, introducing effective therapy, improved staging procedures, and significant improvement of supportive measures, significantly improved the prospects for patients with Hodgkin's lymphoma, leading to a 75-90% cure rate. Hodgkin's lymphoma survivors are at high risk of developing a large variety of second malignant neoplasms. It is crucial to maintain awareness regarding this issue. The subsequent development of Chronic Lymphocytic Leukemia (CLL) in patients after successful treatment of Hodgkin's lymphoma (HL) is an extremely rare possibility. The relationship between these two lymphoproliferative disorders is unclear. Herein we describe two cases of CLL, developed in previously treated patients with HL, with characterization of two distinct lymphoproliferative disease in these two patients. We also systematically reviewed the existing literature on this very rare occurrence of treatment-induced second hematological malignancies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Report of a rare case of acute megakaryocytic leukemia(Turkish Society of Haematology, 2005); ; ; ; Marija Lozance - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SYMMETRIC DIMETHYL ARGININE AND N-ACETYL-Β-DGLUCOSAMINIDASE LYSOZIMURIA OF PROXIMAL RENAL TUBULES AS A TARGET FOR NEPHROTOXICITY IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH DISEASE MODIFYING ANTIRHEUMATIC DRUGS(2013); ;Arif Latifi ;Nada Marina ;Jordan CalovskiBackground: The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA). Objectives: To determine whether there is a change in clinical and laboratory indicators of renal function in course of the follow up of treatment and whether that change correlates with the dynamics of the quantity of enzymes excreted in urine and reactants of the acute phase. Materials and Methods: Using colorimetric method for determination of NAG, samples of 70 participants were examined (35 RA patients treated with Ketoprofen only, 35 RA patients treated with combined use of Methotrexate and Ketoprofen). The follow up was 5 time-intervals in the course of 24 weeks. Results: There was moderate correlation between NAG and microalbuminuria (r=0,34) in the group of patients treated with Ketoprofen only, while statistically significant correlation (r=0,21) was seen in group of patients with combined use of Methotrexate and Ketoprofen. NAG enzymuria in size, number of patients registered, and time of appearance were greater and appears earlier in the group with the combined use of Methotrexate and Ketoprofen compared with the mono-therapy with Ketoprofen. Mean urinary NAG induction was increasing with the concomitant use of Methotrexate and Ketoprofen. Conclusions: Methotrexate is more potent NAG inductor than Ketoprofen and provokes greater tubular enzymuria than Ketoprofen.
