Faculty of Medicine

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Author: search.filters.author.Angelkova N

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    Screening for autism so Modified checklist for autism in toddlers-revised
    (Македонско лекарско друштво = Macedonian Medical Association, 2017)
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    Angelkova N
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    Autistic spectrum disorder-neuropediatric approach and treatment
    (Македонско лекарско друштво = Macedonian Medical Association, 2017)
    Angelkova N
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    Dukovska V
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    Sabolic V
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    Tic disorder in the pediatric population
    (SHMSHM / AAMD, 2017)
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    Angelkova N
    Tics are defined as a recurrent, non-rhythmic series of movements, of a non-voluntary nature, in one or several muscle groups. Tics are sudden twitches, movements, or sounds that people do repeatedly. They can take place anywhere on the body and be very frequent. The lifetime prevalence of tic disorder is not known but estimates vary between 5% and 10% of the population, with estimations of 18% in child population. No definitive cause of tics has been discovered yet. Vulnerability to tic disorders seems to be genetic or to run within families, even though no single gene has been found. High rates of comorbid conditions are recognized in persons with tic disorders especially in patients with Tourette syndrome, like obsessive-compulsive disorder, attention-deficit/hyperactivity disorder and anxiety disorders. Currently, there is no one effective cure for tic disorders, but there are treatments that can help manage them. The therapeutic approach should be determent individually and conducted by multidisciplinary team.
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    MOST COMMON FACTORS AFFECTING OCCURRENCE OF NEONATAL SEPSIS - CHALLENGE AND EXPERIENCE FOR TREATMENT AT NEONATAL INTENSIVE CARE UNIT
    (Macedonian association of anatomists and morphologists, 2018)
    Najdanovska-Aluloska Natasa
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    Angelkova N
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    Background: Neonatal sepsis remains a serious complication, especially among preterm infants. Neonatal sepsis is divided into early- and late-onset sepsis, based on timing of infection and presumed mode of transmission. Early - onset sepsis is defined by onset with in the first week of life, to infections occurring in the first 72 hours due to maternal intrapartum transmission of invasive organisms. Late - onset sepsis is defined as infection occurring after one week and is attributed to pathogens postnatally acquired. Materials and Methods: We have investigated neonatal sepsis in our NICU from 1 January till 31 December 2017, for one-year period, in order to determine mortality associated with sepsis and to identify the dependent predictors for morbidity and mortality. A total 216 infants were admitted in the NICU. Data were collected regarding the primary reason for NICU, maternal condition, gender, gestational age, length of NICU stay, duration of MV and non-invasive ventilation, using of umbilical catheter, and peripherally vein line. Results: Early - onset sepsis was detected in 15 neonates (12 %) within the first 72 hours. Late - onset sepsis was detected in 18 neonates (3,2 %) after 72 hours. Premature infants 23 (70 % range 26 - 37 gestational age) were more exposed to sepsis than term infants 10 (30 %; range 38-40 gestational age). 15 neonates (45,5%) were exposed to the early - onset sepsis, and 18 neonates (54,5%) were exposed to late-onset sepsis. The most frequent isolates were Staphylococcus aureus 7 ( 21,2 %), followed by Acinetobacter 6 (18,1 %), Meticillin- resistant Staphylococcus aureus 5 (72 % from total 7 Staphylococcus aureus) and Staphylococcus epidermidis 5 (15,1%), followed by Klebsiella pneumoniae 2 ( 6,06 % ), Serratia 2 (6,06 %) and Pseudomonas aureginosa 2 (6,06 %). Late - onset sepsis was significantly more common in premature infants. We confirmed that neonatal sepsis resulted with increase duration of NICU stay and duration of MV. Early diagnosis, followed by appropriate antibiotic treatment, short hospital stay and restricted use of invasive devices should be the aims to reduce the risk of late - onset sepsis during the stay in the NICU. Conclusion: Neonatal sepsis is a major cause of death in infants despite sophisticated neonatal intensive care. Early and adequate antibiotic therapy decreases the risk of morbidity of hospitalized patients.