Faculty of Medicine

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    Item type:Publication,
    А rare case of left ventricular hypertrophy and non-compaction cardiomyopathy in an adult: diagnostic approach
    (Macedonian Society of Cardiology, 2021-03)
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    Zafirovska, P
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    Risteski, D
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    Left ventricular non-compaction cardiomyopathy (LVNC) is a rare form of primary genetic cardiomyopathy which is characterized by prominent trabeculations and intertrabecular recesses that communicate with the cavity of the left ventricle. The prevalence is between 0.014%-1.3% in the general population. LVNC is associated with different genetic mutations and may have a genetic overlap with the phenotype of other cardiomyopathies, including hypertrophic cardiomyopathy (HCM). In this case report we present a 26-year-old female patient presenting to emergency room with bradycardia and syncope. The transthoracic echocardiography revealed hypertrophy and trabeculations with prominent recesses of the left ventricle. Cardiovascular magnetic resonance imaging (MRI) was performed to confirm the diagnosis of LVNC. The genetic analysis showed mutation of PRKAG2 gene indicating hypertrophic cardiomyopathy with conduction disturbance. In the last years, LVCN and HCM are diagnosed more frequently due to improvements in imaging methods. Although there are many diagnostic tools including contrast ventriculography, CT and MRI, echocardiography is the main imaging method used for diagnostic evaluation of LVNC and HCM. Key words: left ventricular non-compaction cardiomyopathy, hypertrophic cardiomyopathy, echocardiography, cardiovascular magnetic resonance imaging
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    Item type:Publication,
    CORONARY ARTERY BYPASS GRAFTING PORTENDS DECREASED RIGHT VENTRICULAR FUNCTION
    (Macedonian Association od Anatomists, 2020-07-03)
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    Sokarovski, M
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    Lazovski, N
    Decreased right ventricular (RV) function is a frequently observed phenomenon after coronary artery bypass grafting (CABG) that often implicated poor long term prognosis. The aim of this study was to assess the existence of RV dysfunction 4 to 6 months after CABG using echocardiographic Assessment of tricuspid annular plane systolic motion (TAPSE) and RV free wall longitudinal strain (RVFWS) using speckle tracking. During the period from October 2017 to October 2018, forty-seven consecutive patients undergoing CABG were enrolled in this prospective study. 2D transthoracic echocardiography was performed within one week before CABG as well as 4 to 6 months after surgery. All measurements were made by a single experienced investigator.4-6 months after CABG right atrial (RA)and RV dimensions were significantly increased although the mean value stayed in reference margins. TAPSE was significantly reduced (p=0.0001) as well as RVFWS (p=0.015) which showed fewer negative results implicating decrement in RV function after surgery. Patients with abnormal postoperative RVFWS had insignificantly larger preoperative end-diastolic and end-systolic volume index as well as worse left ventricular (LV)function manifested with lower LV ejection fraction (LVEF), lower systolic volume index (SVI) and more positive LV global longitudinal strain.We could not find any significant difference among preoperative values of RA and RV dimension as well as TAPSE and PAPs between patients with normal vs. abnormal postoperative RVFWS. Our study showed depressed RV function 4-6 months after CABG. We suggest that RV free wall strain could be obtained and should be applied along with other conventional markers in the assessment of RV function after CABG.
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    Item type:Publication,
    Changes of left ventricular systolic function in patients undergoing coronary artery bypass grafting
    (Scientific Foundation SPIROSKI, 2019)
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    Sokarovski M
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    Ristevski P
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    AIM: This prospective study was designed to evaluate the changes in left ventricular (LV) systolic function after coronary artery bypass grafting (CABG) in patients with both normal and abnormal pre-operative systolic function. METHODS: During the period from October 2017 to October 2018, forty-seven consecutive patients undergoing CABG were enrolled in this prospective study. Transthoracic echocardiography was performed within 1 week before CABG as well as 4 to 6 months after surgery. All measurements were made by a single experienced investigator. RESULTS: While the mean LV ejection fraction (LVEF) showed neither improvement nor significant reduction in the whole group of patients following CABG (from 54.21 􏰪 15.36 to 53.66 􏰪 11.56%, p = 0.677), significant improvement in LVEF was detected in the subgroup of patients with pre-operative LV dysfunction (from 40.05 􏰪 8.65 to 45.85 􏰪 9.04%, p = 0.008). On the other hand, there was a significant decline in LEFT in the subgroup of patients with normal pre-operative LEFT (from 64.70 􏰪 9.72 to 59.44 􏰪 9.75%, p = 0.008). As for the other parameters of systolic function, significant decrease in LV end-diastolic volume index (LVEDVI) (p = 0.001), LV end-systolic volume index (LVESVI) (p = 0.0001), wall motion score index (WMSI) (p = 0.013) and LVmass index in male patients (p = 0.011) was shown only in patients with decreased LVEF after CABG. Patients with improved postoperative LVEF (53.2% of all patients) had significantly lower baseline LVEF (p = 0.0001), higher LVESVI (0.009) and higher WMSI (p = 0.006) vs patients with worsened postoperative LVEF (38.3% of all patients). Postoperative improvement of LVEF was correlated with stabile angina, lack of preoperative myocardial infarction and smoking, higher baseline WMSI, higher LV internal diameters and indexed volumes in diastole and systole and lower baseline LVEF. In stepwise linear regression analysis the value of baseline LVEF appeared as independent predictor of improved LVEF after CABG (B = 0,836%; 95% CI 0.655-1.017; p = 0.0001). CONCLUSION: Our study showed that LVEF, internal baseline diameters and indexed volumes of LV in diastole and systole are important determinants of postoperative change in LVEF. In patients with preoperative depressed myocardial function, there is an improvement in systolic function, whereas in patients with preserved preoperative myocardial function, the decline in postoperative LVEF was detected.