Faculty of Medicine
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Item type:Publication, VITAMIN D STATUS AMONG PREGNANT WOMEN OF NORTH MACEDONIA:ASSESSING DEFICIENCY RATES AND ASSOCIATED RISKS FACTORS(Walter de Gruyter, 2025-04-16); ;Aleksovski, Vasko; ;Gjorgievska Nikolovska, ElenaObjective. Vitamin D is an essential vitamin that plays a key role in maintaining overall health. During pregnancy, the demand for vitamin D increases to support the growing needs of the fetus. Vitamin D deficiency is highly prevalent in pregnant women worldwide. The aim of our study was to evaluate the vitamin D deficiency rate among pregnant women in the Republic of North Macedonia, along with influencing factors. Materials and Methods: We conducted a prospective study of randomly selected pregnant women with different body mass index and in two different seasons among vitamin supplementation users and non-users. Results: A total of 309 pregnant women aged > 18 years were recruited from August 2022 to January 2023, with an average vitamin D concentration of 38.9 (36.6-40.2) nmol/l. During the winter period, 80.8 % of pregnant women had vitamin D deficiency. Conclusion: Despite the fact that more than 77.3 % of pregnant women consume multivitamins containing vitamin D, vitamin D deficiency is highly prevalent among pregnant women especially among obese pregnant woman and during the winter months. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BEYOND SEIZURES: BONE MINERAL DISORDERS IN CHRONIC EPILEPSY-A CROSSSECTIONAL STUDY(Macedonian Neurological Society, 2025-10) ;Babunovska, Marija ;Boshkovski, Bojan; ; Kostovska, Irena - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of TNF-α-based models in prognostication of the outcomes after ICH: a pilot study(2019-10); ;Aleksovski, Boris; ; Abstract Introduction: Recently, we have developed TNF-α-based models for prognostication of the 3-month neurological outcome in patients after Intracerebral hemorrhage, ICH (Rendevski et al., 2018). In this pilot study, we aimed to test their utility in the clinical practice for the purposes of identification of the patients who will most likely end up with a poor outcome, as well as to test their utility for clinical decision making between conservative and surgical intervention. Methods: 20 patients with ICH were included initially in this pilot longitudinal study. Their peripheral blood TNF-α levels were screened, and the risk for poor outcome was assessed by using our previously determined cutoff value of > 110.35 pg/mL. The neurological outcome was determined 3 months after the initial hemorrhagic cerebrovascular insult. Another series of 20 threatened patients with TNF-α levels higher than 200 pg/mL were tested for the possibility of lowering the risk of the poor outcome by implementing early craniotomy with hematoma evacuation. Results: The value of > 110.35 pg/mL had fairly identified the patients who later fell into the group with poor outcome, 3 months after ICH (8 out of 9 identified patients with risk for poor outcome have resulted in a poor outcome). In the second series of 20 threatened patients with TNF-α levels higher than 200 pg/mL, early craniotomy and evacuation of the hematoma were shown beneficial; 7 out of 20 patients resulted in a good outcome. Conclusions: TNF-α screening at admission was shown as a useful method for identifying the ICH patients with the highest risk for ending with poor neurological outcome; early craniotomy with hematoma evacuation in the threatened group of patients with the highest TNF-α levels has also shown benefit in lowering the risk for poor outcome and improving patient's neurological state 3 months after ICH. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Validation of the ELISA Method for Quantitative Detection of TNF-α in Patients with Intracerebral Hemorrhage(Scientific Foundation SPIROSKI, 2017-09); ;Aleksovski, Boris ;Stojanov, Dragan ;Mihajlovska-Rendevska, AnaAleksovski, Vasko<jats:p>AIM: We aimed to investigate the sensitivity, reproducibility and validity of the commercial ELISA kits for quantitative detection of TNF-α and their potential application for screening purposes in patients with ICH.METHODS: Analysis of six independent standard series, evaluation of the deviation of the TNF-α concentration in patients with ICH, standard addition and visual analysis of whole UV-Vis spectra were carefully performed.RESULTS: Low standard deviations of the absorbance were detected for every standard, as well as in the samples of healthy controls and patients with ICH. The standard addition series have also confirmed high sensitivity and reproducibility of the assay, with a congruent shift of the standard curves with the concentration of TNF-α for the added plasma. The visual analyses of the gained spectra have revealed the absence of any matrix effects from the addition of the human plasma in the reconstituted standards.CONCLUSION: The commercial ELISA kits can be used in the clinical practice for screening purposes of the plasma TNF-α levels in patients with ICH.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Kinetics of Antibody Response to Repeated Vaccination with Sputnik V: A Pilot Study with a Series of Five Cases(2022-08); ;Aleksovski, Vasko; Widespread vaccination is considered as one of the best methods in combating any pandemic including COVID-19. Gam-COVID-Vac also known as Sputnik V, is one of the first vaccines that was registered in 74 countries and received an emergency approval for immunization. Monitoring anti-SARS-CoV-2 antibodies over time is essential for evaluation of post-vaccination humoral immune response.To date, there are only a limited number of clinical studies regarding the analysis of immune response after Sputnik V administration. It is of crucial importance to report independently on safety and efficiency of this vaccine with the aim to speed up the process of its final approval by the WHO. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The impact of glutamate in the development of brain edema in patients with ICH(2016-09); ;Mihajlovska Rendevska, Ana ;Aleksovski, Vasko; - Some of the metrics are blocked by yourconsent settings
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