Faculty of Medicine
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Item type:Publication, CLINICAL OUTCOMES FROM COVID-19 INFECTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: 5 YEARS LATER(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-12-16); ; ; ;Atanasovska, AnetaIntroduction: Evidence of impact of COVID-19 infection on course of chronic obstructive pulmonary disease (COPD) is still limited. Aim: To assess clinical outcomes of moderate COVID-19 infection in patients with moderate COPD by comparison of disease control, i.e., the frequency and severity of symptoms, level of health status impairment, values of spirometrc parameters and exacerbation risk, registered at two points in time: 2020 and 2025. Material and methods: We performed a cross-sectional study including 74 patients with moderate COPD divided in two groups. The first group (COVID-19 group) included 37 COPD patients who had COVID-19 infection of moderate severity in 2020. The second group (non-COVID-19 group) included patients with COPD who did not have coronavirus disease in the period 2020-2025. The frequency and severity of symptoms and level of health impairment were assessed by COPD Assessment Test (CAT): lung function was assessed by spirometric measurements, and exacerbation risk was predicted by exacerbation rate registered in the previous year. Conclusion: Our findings indicated significant impact of the COVID-19 infection on symptoms, patient’s health and daily life, as well as on the lung function and exacerbation risk emphasizing a need of careful monitoring of these patients upon recovery from COVID-19 infection in order to minimize the impact of infection on COPD progression. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE AND CHARACTERISTICS OF CHRONIC RESPIRATORY SYMPTOMS AND LUNG FUNCTION AMONG VINEYARD WORKERS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-12-16); ; ; ;Atanasovska, AnetaBislimovska, DraganaAim: To determine the frequency of chronic respiratory symptoms and ventilatory function in a group of vineyard workers. Results: Most of the vineyard workers believe that they are sufficiently informed about the health risks related to their work activities and the necessary measures needed for health protection. Also, most of them use the mandatory personal protective equipment, while almost all workers during their work, to a greater or lesser extent, were exposed to occupational respiratory hazards: dust, smoke, fumes, gases and pesticides. About 45% of subjects had one or more respiratory symptoms, and the most common symptoms were cough (40%), cough with phlegm (31.1%), as well as dyspnea and wheezing (22.2%). The frequency of chronic respiratory symptoms was higher in workers with more than 15 years of exposure, with a statistically significant difference in frequency of cough, cough with phlegm, and dyspnea. The risk of respiratory symptoms was about 3 times higher in active smokers and about 2 times higher in vineyard workers with exposure duration longer than 15 years. The mean values of all spirometric parameters were within the reference values, while lung function impairment of obstructive, restrictive and combined pattern was registered in about 20% of them. The mean values of spirometric parameters in vineyard workers with exposure duration longer than 15 years were lower than those with less than 15 years of experience, with a significant difference for small airways flow indices. Conclusion: The obtained results indicate the need to improve preventive measures.</jats:p> - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Association between occupational exposure and cancer in developing countries: a systematic review(2025-10-08); ; ; Petrovska, EkaterinaObjective: This systematic review aims to identify, evaluate, and synthesize existing evidence about the association between occupational exposure and cancer in developing countries, to conduct risk of bias assessment (RBA), and to identify knowledge gaps to guide future research. Material and Methods: A systematic review is currently conducted across three major databases—MEDLINE (via PubMed), EBSCO, and DynaMed—including studies published between 1990 and 2025. The search strategy was developed in accordance with the PICOs framework, using a combination of search terms, Medical Subject Headings (MeSH), and Boolean operators (AND, OR, NOT) to identify relevant studies. The ongoing first phase of this systematic review (MEDLINE database) initially identified a total of 1,759 records which were screened based on title and abstract. For the resulting 41 records, the full-text articles were assessed for eligibility. Following the exclusion criteria, four articles without an existing abstract and 28 review articles were removed. In accordance with the inclusion criteria, only original research articles were considered, resulting in 9 full-text articles being included for qualitative synthesis. Screening of EBSCO and DynaMed databases will be conducted in the next phase of the review. RBA was based on the criteria proposed by Shamliyana et al. Results: Preliminary data showed that the most frequently analysed occupational carcinogens in developing countries were: asbestos, silica dust, pesticides, arsenic, and particulate matters. Mostly investigated cancer sites were: lung cancer, melanoma, leukaemia, and colo-rectal cancer. The RBA showed external and internal validity issues for most of the studies. Conclusion: There is a clear need to improve evidence synthesis on occupational exposure and cancer in developing countries, where the burden could be greater but research is limited. Acknowledgements: The authors declare no funding or conflicts of interest. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Artificial Intelligence-Generated Answers to Patients' Questions on Asthma: The Artificial Intelligence Responses on Asthma Study(Elsevier BV, 2025-09) ;Nigro, Mattia ;Aliverti, Andrea ;Angelucci, Alessandra ;Braido, FulvioCanonica, Giorgio WAsthma is a prevalent chronic respiratory disease requiring ongoing patient education and individualized management. The increasing reliance on digital tools, particularly generative artificial intelligence (AI), to answer health-related questions has raised concerns about the accuracy, reliability, and comprehensibility of AI-generated information for people living with asthma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Data from the Researcher Mental Health Observatory STAIRCASE survey(Center for Open Science, 2025-05-24) ;Lasser, Jana ;Mol, Stefan Thomas ;Čontala, Alja ;Slavec, Anade Swarte, Andreja ZulimThe data presented here derives from the STAIRCASE survey on researcher mental health. The survey reached 4,296 researchers predominantly from European countries who completed an online questionnaire about mental health outcomes such as depression, anxiety, stress, burnout, and well-being, as well as working conditions and leadership behaviour. Data and materials of the study are available at https://doi.org/10.21249/DZHW:remo:1.0.0 as a fully anonymised downloadable Campus Use File and a pseudonymised Scientific Use File, accessible in a secure remote analysis environment. Data can be reused for secondary analyses, educational purposes, or combined with similar data sets. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Prevalence of Symptomatic Dermographism: Results of the International UCARE PREVALENCE-D Study(Wiley, 2025-09-13) ;Kulthanan, Kanokvalai ;Bernstein, Jonathan A ;Rudenko, Michael ;Salameh, PascaleKomoltri, ChulalukThe prevalence of symptomatic dermographism (SD) in the general population remains unclear. This study aimed to internationally estimate the prevalence of SD and two other dermographic subtypes-physiological red dermographism and simple urticarial dermographism-among adults worldwide. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Impact of night work on health and work ability among healthcare workers(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, Co-publisher Scientific foundation Spiroski, 2025-08-15); ;Asani Kuki, Gjulsever; ; Veljikj Stefanovska, VesnaAim of the study. The study objective was to determine the impact of night work on health and work ability of health workers. Material and methods. This was a cross-sectional study conducted with an anonymous survey questionnaire distributed among 120 health workers employed in PHICGH „8th September“ - Skopje, in the period January-May 2024. The study comprised male and female subjects aged 21 to 62 years, 86.7% of them worked full-time, 60% worked in shifts, 40% worked only in the first shift, while 50% of them also had night shifts. Results. Тhe mean age of examined subjects was 40.9±10.6 years, and the average length of service in the current workplace was 11.8±8.9 years (range 1-42 years). 44.2% of them were active smokers with an average smoking experience of 6.2±9.1 years, while only 2.5% of them drank alcohol daily in an amount greater than one large glass (200 ml) of beer/wine or one small glass (50 ml) of brandy or other strong drink. A significant difference between subjects who worked and those who did not work night shifts was determined for the consumption of alcohol in a larger amount (P=0.030), followed by dissatisfaction with the workplace (P=0.031), as well as in dissatisfaction with life (P=0.042). The majority of subjects believed that psychophysical abilities during and after night work were worse than during day work,66.6% of them answered that they had difficulties in sleeping after night shifts. The frequency of cardiovascular diseases was significantly higher among subjects who worked night shifts compared to those who did not work (P=0.043), together with the frequency of health conditions that require regular medication at a strictly defined time (P=0.037). The average values of current work ability in subjects who worked night shifts and those who did not work night shifts were similar. Conclusion. The results of the study evidently showed a significant impact of night work on health and well-being as well as on work ability of health workers. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COPD prevalence and characteristics among sample of working population(Frontiers Media SA, 2025-05-27); ; ; ;Brborović, HanaMilošević, MilanIntroduction: COPD is a global public health problem, causing a very high rates of morbidity, mortality, and work disability in the last decades worldwide. Objective: To determine the prevalence and characteristics COPD in a random sample of workers form the city of Skopje, and its relation to occupational exposures. Methods: A cross-sectional study was conducted including 1,867 workers (959 males and 908 females) from the city of Skopje. Afterwards, the study subjects were divided into exposed (1.287/68.9%) and unexposed (580/31.1%) groups based on their current job exposure to noxious particles and gasses. All study participants completed a questionnaire and underwent pre-and post-bronchodilator spirometry. Results: COPD prevalence was 3.9% among all workers. COPD prevalence in exposed workers was significantly higher compared to unexposed (4.7% vs. 2.4%). Significant difference was found in exposed workers with exposure duration longer than 20 years as compared to those with shorter duration of exposure (6.0 vs. 3.2%). COPD prevalence in workers who smoked was significantly higher than in non-smoking workers in both exposed (6.0% vs. 3.9%, p = 0.037) and unexposed (3.9% vs. 1.8%, p = 0.000) groups. The difference between workers with COPD in terms of use of solid and liquid bio fossil fuels at home and central heating/electricity is not significant (5.0% vs. 3.6%), both in exposed (5.4% vs. 4.3%), as well as non-exposed workers (3.8% vs. 1.9%). Conclusion: Our findings confirmed the role of occupational exposures in COPD prevalence indicating a need of more effective preventive activities in order to reduce the overall disease burden. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE RELATIONSHIP OF PERSISTENT HUMAN PAPILLOMAVIRUS INFECTION AND STRESS AT THE WORKPLACE(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-04) ;Micevska, Megi; ; ; Introduction: Human papillomavirus (HPV) is one of the most common sexually transmitted infections. While most genital HPV infections regress spontaneously, some persist and can progress to cervical cancer. The biological susceptibility to acquire HPV and the immunological capacity to eliminate the infection are influenced by various factors, including occupational roles, work-related stress, and burnout syndrome. Materials and methods: In our study, relevant data were collected from 71 patients, 38 of whom had documented persistent HPV infections, while 33 patients were included in the study as a control group. Among those with persistent HPV infections, HPV 16 was the most common type, followed by HPV 31 and HPV 52. Results: Job demands were assessed using the Job Demands Questionnaire. The burnout syndrome was evaluated with the Maslach Burnout Inventory. Job resources were investigated using the Hospital Survey on Patient Safety Culture Questionnaire and the English version of the Questionnaire sur les Ressources et Contraintes Professionnelles. Conclusion: Preliminary data analysis revealed significantly higher levels of stress factors in the group of patients with persistent HPV infections compared to the control group. The insights gained from assessing the impact of workplace stress on HPV infection progression will help formulate recommendations to promote the health of the working population.
