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    THE INCIDENCE OF NEONATAL SEPSIS AT A TERTIARY NEONATAL INTENSIVE CARE UNIT (A 9 MONTHS SURVEY)
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, "Ss. Cyril and Methodius"University, R.N.Macedonia, 2021-10-03)
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    Bushinoska Jasna
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    Orovchanec Nikola
    ABSTRACT Introduction: Neonatal sepsis is severe infection that affect newborns in the first 28 days of live. The first 28 days of life of newborns are the most vulnerable period in life of newborns, known as neonatal period of live. Newborns may be infected before, during or after the birth. Neonatal sepsis as a blood stream infection could be presented like pneumonia, pyelonephritis, gastroenteritis, osteomyelitis, arthritis or meningitis in newborns. Neonatal sepsis can be diag nosed by clinical signs of sepsis or with a positive microbiological culture-culture proven sepsis. Research Purpose: The purpose of this study is to show the incidence of neonatal sepsis, neonatal mortality caused by sepsis in early and late neonatal period, and the most common bacterial triggers of neonatal sepsis in the given period, among live-born newborns at the GOC Skopje, treated at NICU in the first 28 days after delivery. Material and Methods: This prospective analysis elaborates on incidence of neonatal sepsis, neonatal mortality caused by sepsis and the most common bacterial triggers of neonatal sepsis in live-born neonates in the first 28 days after delivery at the GOC-Skopje, in the period 01.05.2019-31.01.2020. The data is collected from the Data basis at NICU and the medical his tories of women that gave birth and the histories of newborns at GOC-Skopje, during this period. Results: During this period of 9 months at GOC-Skopje, there were 3,453 live-born new borns, out of which 445 newborns were transferred and treated at NICU. 124 of these newborns, developed clinically and laboratory signs of neonatal sepsis, or 36 on 1000 live-births. 32 (25.8%) of newborns which developed neonatal sepsis, died in neonatal period or 9 on 1000 live-births. The most common bacterial cause for neonatal sepsis were Klebsiella pneumoniae, followed by Staphylococcus aureus, Enterobacter species, Serratia marcescens and Escherichia coli. Conclusion: The hospital neonatal sepsis and mortality from neonatal sepsis at GOC-Skopje is quite higher than in the developed countries of the world.
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    EVALUATION OF PROCALCITONIN AND SERUM ALBUIN LEVELS AS EARLY INFLAMMATORY BIOMARKERS IN NEONATAL SEPSIS
    (Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2020)
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    Kimovska M
    Prematurity is the leading cause of death globally, and the second largest contributor to all deaths under the age of 5. The aim of this study was to evaluate serum albumin levels and procalcitonin levels for the diagnosis and prognosis of preterm newborns with neonatal sepsis. In this study, we included 100 hospital admitted preterm newborns with the first 24 hours of life, hospitalized at the Intensive Care Unit at the University Children's Hospital-Skopje, for the time period between November 2018 until 30 April 2020. The preterm newborns have been divided into three groups according to albumin levels (>30, 25-30, or <25 g/l). There was a highly significant difference between the discharge diagnosis groups, regarding their serum albumin levels and Procalcitonin (PCT) levels, and there was a significant correlation between serum albumin level and PCT levels in preterm newborns, as well. Lower serum albumin levels might be associated with a poorer prognosis in neonatal sepsis. Serum albumin and procalcitoni levels have been proposed to be an early marker for the diagnosis of neonatal sepsis and a valuable follow-up tool.