Faculty of Medicine

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    Superficial dorsal vein rupture mimicking penile fracture
    (Македонско лекарско друштво = Macedonian medical association, 2025-04)
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    Tochko, Ognen
    University clinic for surgical diseases “St. Naum Ohridski” Skopje Penile trauma is a rare, but distressing condition that can cause significant anxiety for affected patients. We present the case of a 23-year-old man who arrived at our emergency department with sudden penile swelling and ecchymosis following sexual intercourse. The patient reported immediate pain and rapid subcutaneous hematoma formation, but did not hear a cracking sound. Clinical examination revealed significant swelling and discoloration over the dorsal aspect of the penis without palpable tunical defect or signs of urethral injury. Given the concern for penile fracture, surgical exploration was performed. Intraoperatively, we identified an isolated rupture of the superficial dorsal vein with an extensive hematoma, but an intact tunica albuginea. The injured vessel was ligated, and meticulous hemostasis was achieved before wound closure. The postoperative course was uneventful, and the patient was discharged the following day with recommendations for conservative management, including abstinence from sexual activity for four weeks. At the one-month follow-up, the patient reported complete resolution of symptoms with preserved erectile function and no recurrence of hematoma. This case highlights the difficulty in distinguishing superficial dorsal vein rupture from penile fracture based on clinical findings alone and emphasizes the importance of surgical exploration in uncertain cases to ensure proper diagnosis and treatment.
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    Unusual initial presentation of prostate adenocarcinoma with inguinal lymph nodes metastases: a case report
    (Oxford University Press (OUP), 2024-04-01)
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    Burneski, Jovo
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    The presence of lymph node metastases in prostate adenocarcinoma is a poor prognostic sign, and mortality rates are often high. Inguinal lymph node metastases are an unusual presentation of advanced disease, and they can be easily misinterpreted with other diseases. We present a case of a 63-year-old patient with no previous symptoms and signs of prostate disorder with a right-sided inguinal lump and abdominal pain. The CT scan showed right inguinal and retroperitoneal lymphadenopathy. Elevated PSA serum levels, digital rectal examination, and skeletal scintigraphy with 99mTc-MDP favored the diagnosis of metastatic prostate adenocarcinoma. Since the patient denied prostate biopsy, a dissection of the right inguinal nodes was performed. Histopathological findings confirmed metastatic prostate adenocarcinoma. The treatment was hormonal and bisphosphonate therapy, with objective posttreatment improvement. Based on this case, it can be concluded that inguinal and generalized lymphadenopathy are potential initial manifestations of metastatic prostate adenocarcinoma in male patients.
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    Acquired Inhibitors (Autoantibodies) to Factor VIII: A Case Report and Review of Literature
    (Istanbul University, istanbul faculty of Medicine, 2010)
    Vera Stankovic
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    Magdalena Ivanova
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    Borislav Manev
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    Report of a rare case of acute megakaryocytic leukemia
    (Turkish Society of Haematology, 2005)
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    Marija Lozance
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    Patient with Antineutrophil Cytoplasmic Antibody Associated Small Vessel Vasculitis, Acute Renal Failure, and Coronavirus Disease-19 Pneumonia: A Diagnostic and Therapeutic Challenge
    (ID-Design/Scientific foundation SPIROSKI, 2020-11)
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    Zvezdana Petronijevik
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    Blagica Pecanova
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    Gjorgi Stojchev
    BACKGROUND: Antineutrophil cytoplasmatic antibody (ANCA)-associated vasculitis (AAV) has a predilection for the kidney and more than three quarters of patients have renal involvement with rapidly progressive glomerulonephritis. Small-vessel systemic vasculitis may present as pulmonary-renal syndrome and is characterized by necrotizing glomerulonephritis and pulmonary hemorrhage. Diagnosis and therapy for AAV in coronavirus disease (COVID) COVID-19 pandemic require multi-disciplinary collaboration due to the affection of multiple systems and risks associated with immunosuppressive medications. CASE REPORT: A 69-year-old non-smoker, non-diabetic female presented in the outpatient unit at the department of pulmonology with dry cough, malaise, and sub-febrile temperature, lasting for 1 month. The patient had a high suspicion of severe pulmonary-renal syndrome, ANCA-AAV, and acute renal failure requiring hemodialysis. She was treated with corticosteroids, cyclophosphamide, and plasma exchange. The treatment led to temporary improvement. Infections with COVID-19, Enterococcus in the urine, and Acinetobacter in the tracheal aspirate further complicated the clinical picture and despite antibiotic treatment, use of tocilizumab and convalescent plasma, the outcome was lethal. CONCLUSION: It is important to establish the diagnosis and distinguish accurately between vasculitis and infection to provide adequate and timely therapy.