Faculty of Medicine
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Item type:Publication, CLINICAL-PATHOLOGICAL EVALUATION AND FOLLOW-UP OUTCOMES IN PRIMARY BLADDER TUMOR PATIENTS TREATED AT UROLOGY CLINIC(Македонско лекарско друштво = Macedonian medical association, 2024); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidental prostate cancer in patients undergoing radical cystoprostatectomy in treatment for bladder cancer: our five-year results(SHMSHM - AAMD, 2013); ; ; The aim of the paper was to verify the incidence and features of incidental prostate cancer in patients who underwent radical cystoprostatectomy for invasive bladder cancer. Methods and results: A total of 96 patients underwent radical cystoprostatectomy between January 2006 and December 2010 in the University Clinic of Urology in Skopje. 10 patients were excluded for incomplete data. The average age of the study group was 61.2 years (range 32-78). Prostate cancer was found in 10 (11.6%) cases. Seven patients were clinically insignificant. Conclusion: Incidentally diagnosed prostate cancer was frequently insignificant. Digital rectal examination and prostate specific antigen should be part of the diagnostic procedure in patients who undergo cystoprostatectomy. Standard RCP which include removal of bladder with prostate gland and seminal vesicles is safer for radicality and prevention of residual prostate cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CORRELATION OF PD-L1 GENE EXPRESSION WITH GRADE OF THE URINARY BLADDER CANCER(Македонско лекарско друштво = Macedonian medical association, 2023-12); ; ; Abstract Introduction. Bladder cancer (BC) ranks fourth in the prevalence of malignancies in developed countries and is the eighth leading cause of cancer-related mortality in men. PD-L1, known for its role in inhibiting immune responses against malignant cells, has garnered significant attention in BC research. Methods. This study, comprising 45 patients with histopathologically confirmed urothelial carcinoma of the urinary bladder, analyzed the connection between histological grade and PD-L1 gene expression. The patient cohort was divided into 31 classified as low-grade and 14 as high-grade, with gender and age distribution well-balanced across the groups. PD-L1 expression was notably higher in the high-grade group (p=0.005), showing its potential clinical relevance as a biomarker. Results. Univariate logistic analysis revealed a robust correlation between histological grade and PDL1 expression, with high-grade patients exhibiting a 7.227-fold higher likelihood of increased PD-L1 expression. A predictive model for grade determination demonstrated commendable performance, boasting an area under the curve (AUC) of 0.788. Conclusion. These findings provide compelling evidence of a strong association between PD-L1 gene expression and the histological grade of bladder cancer. PD-L1 emerges as a potential biomarker, shedding light on a disease pathological grade, offering a significant clinical value for precise prognosis, and guiding tailored treatment strategies. These insights hold promise for improved disease management and patient outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Laparoskopna radikalna cistektomija sa ekstrakorporalnom derivacijom urina - početno iskustvo i preliminarni rezultati(Okruzna podružnica SLD Leskovac, 2020); ; SUMMARY Introduction and objectives: To report our experience with laparoscopic radical cystectomy (LRC) and extracorporeal urinary diversion for muscleinvasive bladder cancer. We have evaluated and summarized the surgical outcomes and complications of this procedure. Patients and methods: We have evaluated retrospectively all patients who underwent LRC at our clinic over a one year period. In all patients, ureteroileocutaneostomy (Bricker technique) was performed for urinary derivation. We have analyzed the following parameters: patient demographic data, laboratory data, intraoperative fluid volume, estimated blood loss and transfusion requirements. Respiratory parameters including arterial blood gas data, anesthesia time, surgical time, time of oral intake, admission to ICU (intensive care unit), hospital stay and any adverse events during the whole period of hospitalization were also analyzed. Results: Patients had similar demographic characteristics. Estimated intraoperative blood loss was 392 ml. Due to prolonged surgical time and CO2 pneumoperitoneum, hypercapnia was observed in 3 patients. Patients had a short period of bowel dysfunction and rapid shift from parenteral to oral nutrition, short hospital stay and low rate of surgical compilations. Conclusion: The results of our study have shown that laparoscopic radical cystectomy is a safe, feasible, and effective alternative to open radical cystectomy. Ex tra cor - po real urinary diversion through a small incision decreases the operating time, while maintaining the benefits of laparoscopic surgery. However, some larger prospective evaluation is to be made for summarizing the overall conclusions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of bladder cancer variant histology on survival outcome in patients treated with radical cystectomy: A single-centre experience(Wolters Kluwer - Medknow, 2021-07); ; ; ; Context: Bladder cancer (BC) is the sixth most common malignant neoplasm in men. Recently, great effort has been devoted to the study of BC variant histology (VH). Yet, the results from these studies have shown conflicting data and remain unclear whether their presence alters recurrence and survival rates after radical cystectomy (RC). Aims: We undertook this study aiming to test the effect on VH on recurrence-free survival (RFS) and overall survival (OS) in single-center RC patients. Settings and Design: We have retrospectively analyzed medical records and pathology reports from 331 patients who underwent RC with or without pelvic lymphadenectomy at University Urology Clinic-Skopje, North Macedonia, in the period between 2010 and 2018. Subjects and Methods: Microscopic analysis of the specimens involved the evaluation of histological tumor type, tumor grade, pathological tumor node metastasis stage, presence of lymphovascular invasion, and resection margin status. Statistical Analysis Used: Univariable and multivariable Cox regression models were applied to test the effect of VH on RFS and OS. Results: We found 185 patients who matched our inclusion criteria. At multivariable analyses, lymphovascular invasion and positive resection margins were associated with shorter RFS. Similarly, patients diagnosed with lymphovascular invasion, positive resection margins, and a pelvic lymph node metastasis had poorer OS. VH was not found to be an independent predictor of both RFS and OS (P > 0.05). Conclusions: The present study did not reveal prognostic effect of VH on RFS and OS. In our series, histomorphologic parameters including lymphovascular invasion, resection margins, and pelvic lymph node metastasis were the most relevant predictors on survival outcome after RC.