Faculty of Medicine

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14

Browse

Settings

Access type: UnknownSubject: search.filters.subject.antibodies

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Severe Complicated secondary antiphospholipid syndrome conjointly with lupus erythematosus -case report
    (Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2025-01)
    Vidinikj, Sonja
    ;
    Antova, Dubravka
    ;
    ;
    Guchev, Filip
    ;
    Antiphospholipid syndrome (APS), is an autoimmune systemic disorder known to manifest with thrombosis in almost all vessels throughout the body, can also be accompanied by pregnancy morbidity, and is persistent with the presence of antiphospholipid antibodies, including lupus anticoagulant antibodies, or relatively high titers of anticardiolipin, or anti-β2Glycoprotein I antibodies. APS can occur alone or in association with other diseases, more commonly systemic lupus erythematous. In patients with both underlying diseases episodes of arthritis, skin changes in the form of livedo reticularis, thrombocytopenia and leucopenia were more common. Cardiac manifestations have also been reported. Here we present a complicated case of a young female patient with antiphospholipid syndrome and an underlying systemic lupus erythematosus.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Influence of Duration of Heroin Dependence on Humoral Immunologic Indicators
    (American Society of Addiction Medicine, 2016-06)
    ;
    ;
    ;
    ;
    Irena Jurukov
    Objective: The incidence of autoantibodies may be associated with the duration of drug use. In this study, we assessed the association between the duration of heroin dependence and various humoral immunologic indicators, including IgA, IgG, IgM, complement component 3, complement component 4, rheumatoid factor, antib2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating immune complexes, and cryoglobulins. Methods: A total of 363 patients with heroin dependence were enrolled in this cross-sectional and prospective study over a 3.5- year period. Depending on the duration of heroin use, participants were divided into 3 groups: up to 3 years, 4 to 7 years, and more than 7 years of heroin dependence. All patients were analyzed for the indicators. Results: There was a significant difference between the duration of heroin dependence and increased concentration of IgA (P ¼ 0.0000), IgG (P ¼ 0.0000), IgM (P ¼ 0.0001), complement component 3 (P ¼ 0.042), rheumatoid factor (P ¼ 0.0001), anti-b2-glycoprotein 1 (IgA, P ¼ 0.0098; IgG, P ¼ 0.0000; IgM, P ¼ 0.0000), the presence of antinuclear antibody (P ¼ 0.01) and cryoglobulins (P ¼ 0.0000), and decreased concentration of complement component 4 (P ¼ 0.002). There was no significant difference in circulating immune complex concentration (P ¼ 0.097). Conclusions: A longer duration of heroin dependence was associated with increased concentrations of IgA, IgG, IgM, complement component 3, rheumatoid factor, anti-b2-glycoprotein 1 (IgA, IgG, IgM), presence of antinuclear antibodies and cryoglobulins, and decreased concentrations of complement component 4, but there was no influence on circulating immune complex values.