Faculty of Medicine

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    Immunohistochemical expression of CD44 in patients with hepatocellular carcinoma
    (Macedonian Association of Anatomists and Morphologists, 2020)
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    Nikolovska Trpchevska, Emilija
    Introduction: CD44, a transmembrane glycoprotein with a role in cell-cell and cell-matrix interactions and one of the stem cell markers, is considered to participate in progression and prognosis of hepatocellular carcinoma (HCC), which makes it a potential prognostic marker and therapeutic target. We aimed to evaluate immunoexpression of CD44 in tumor and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathological data in order to determine its prognostic value in patients from the Republic of North Macedonia. Material and Methods: Presence of the immunosignal and the percentage of CD44+ tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined. The immunohistochemistry results were correlated to B and C hepatitis, tumor dimensions, enlarged lymph nodes, T status, differentiation (G), microvascular invasion, and survival. Results: We found a significant difference in CD44 expression between tumor and non-tumor liver tissue (p < 0.000) and significantly higher CD44 expression was also found in T4 tumors in comparison with T1 tumors (p < 0.01). Conclusion: Expression of CD44 was significantly higher in tumor in comparison to non-tumor tissue and was significantly associated to T4 local tumor growth, making it a potential prognostic marker and therapeutic target.
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    DEMOGRAPHIC AND PATHOLOGICAL CHARACTERISTICS OF GASTRIC CARCINOMAS – A Three-Year Single Center Experience
    (Macedonian Association of Anatomists, 2020)
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    Trajkovski G
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    Bushinoska J
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    Nikolova D
    Introduction: Despite the decline in incidence and mortality rate in recent years, gastric carcinoma (GC) remains one of the leading causes of cancer-related deaths worldwide, especially in developing countries. The aim of this study was to present the clinical and pathological characteristics of gastric carcinomas in patients from R. North Macedonia. Material and methods: One hundred and forty-nine patients with gastric carcinoma were included in the study. Sixty-one patients underwent subtotal gastric resection with lymphadenectomy, and 88 patients underwent total gastrectomy with lymphadenectomy. Tumor localization, TNM classification, grade and stage were determined for each patient. The parameters of the TNM classification (AJCC Cancer Staging 2017) were obtained from the archived histopathological reports of the Institute of Pathology in Skopje, and for the clinical stage patients’ files from the University Clinic for Abdominal Surgery in Skopje were used. Results:The most common intragastric location of gastric carcinomas was cardia in 61 (40.94%) patients, followed by antral/pyloric carcinoma location in 51 (34.23%) patients and corpus location in 37 (24.83%) patients. According to the T status (local tumor growth), more than half of the examined patients 84 (56.38%) were in T4 status of the disease. Presence of positive regional lymph nodes was detected in 113 (75.84) patients, and negative in 36 (24.16%) patients. The majority of patients that comprised the analyzed group - 81 (54.36%) had a poor differentiated gastric carcinoma, and 88 (59.06%) were in Stage III of the disease.