Faculty of Medicine

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    Inflammatory markers in peripheral blood in patients with asthma
    (2020-12)
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    Dejan Todevski
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    Monika Tushevska Mitkovska
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    Nikola Chamurovski
    Asthma is one of the most common chronic diseases all over the world, resulting from a state of persistent sub-acute inflammation of the airways. The main attribute of asthma is inflammation, which leads to airway remodeling, bronchial hyper-reactivity and reversible or partly reversible airway obstruction. Asthma is a chronic inflammatory disorder of the airways in which many cells and inflammatory mediators play a role. (GINA). Many cells and mediators take part in creating the asthmatic inflammatory reaction, but eosinophils play a central role. All of the inflammatory cells and mediators can be detected in the airflow tissue. Some of them can be detected in the asthmatics peripheral blood too. This study includes 30 patients of the Pulmology and Allergy Clinic, Skopje, with confirmed bronchial asthma, treated with ICS. In all of the patients we followed Eo count, ECP and IL-5 in peripheral blood at the beginning of the study, after 2 and 6 months treatment. Following the parameters during treatment with ICS we registered changes in all of the tested parameters. Our conclusion is that the ICS objectively suppress the inflammatory reaction in asthma and the biologic markers (IL-5, Eo and ECP), which we have followed, can measure the accomplished effect. They could be used in every day practice, not only as diagnostic parameters but also as valid therapeutic guides in the treatment of asthma
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    Total Eosinophyls, ECP and IL-5 in Peripheral Blood During Treatment with Inhaled Cortikosteroids in Patients with Asthma
    (Turkish Thoracic Society, 2019)
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    Dejan Todevski
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    Monika Tushevska Mitkovska
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    Nikola Chamurovski
    Objectives: The main attribute of asthma is inflammation, which leads to airway remodeling, bronchial hyper-reactivity and reversible or partly reversible airway obstruction. According to GINA, asthma is a chronic inflammatory disorder of the airways in which many cells play a role, in particular mast cells, eosinophils (Eo), and T lymphocytes (GINA). Many cells and mediators take part in creating the asthmatic inflammatory reaction, but eosinophils play a central role. Methods: This study includes 30 patients of the Pulmology and Allergy Clinic, Skopje, with confirmed bronchial asthma, treated with ICS. In all of the patients we followed Eo count, ECP and IL-5 in peripheral blood at the beginning of the study, after 2 and 6 months treatment. Results: At the beginning of the study in all 30 (100 percent) of the patients the serum level of IL-5, Eo count and ECP were increased. Following the parameters during treatment with ICS we registered statistical significant changes in all of the tested parameters. Conclusion: Our conclusion is that the ICS objectively suppress the inflammatory reaction in asthma and the biologic markers (IL-5, Eo and ECP), which we have followed, can measure the accomplished effect. They could be used in every day practice, not only as diagnostic parameters but also as valid therapeutic guides in the treatment of asthma.
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    Correlation of Total Eosinophils in peripheral blood with bronchoprovocative testing with acetylcholine in patients with bronhchial asthma
    (2015)
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    Gjorcev A
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    Todevski D
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    Janeva E
    The main attributes of asthma are airway obstruction, spontaneous or treatment induced reversibility, increased bronchial reactivity to exogenous and endogenous stimuli (triggers) and inflammation of the tracheobronchial tree. Since the basic characteristic of asthma is airway hyper reactivity, proving the existence of airway reactivity can make valid diagnosis. The airway hyperactivity is caused by airflow inflammation. Nevertheless, the markers of asthmatic inflammation can also be present in peripheral blood. Two methods for detection of airway inflammation were used in this study, PC20 to methacholine bronchoprovocation and eosinophyl (Eo) count, ECP and IL-5 in peripheral blood. We estimated their correlation. This study includes 30 asthmatic patients of the Pulmology and Allergy Clinic, Skopje, Macedonia. In all of the patients Eo count, ECP and IL-5 in peripheral blood and PC20 to methacholine bronchoprovocation were followed at the beginning of the study, after 2 and 6 months. The results show statistically significant correlation (p<0.05) between markers of inflammation in peripheral blood and PC20 to methacholine. Our conclusion is that each of the evaluated markers may be used in the diagnosis of asthma, alone or in combination. The inflammatory markers in peripheral blood can be used as a screening method in the management of asthma as well as a diagnostic parameter for asthma, especially in cases when bronchoprovocative tests can not be performed.