Faculty of Medicine
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Item type:Publication, APPLICATION OF CERTAIN CARDIOLOGICAL AND KINESIOLOGICAL PROTOCOLS DURING THE PROCESS OF REHABILITATION OF THE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION(University of Tetova, 2024) ;Denis ALIU ;Zhaku, VegimThis study focuses on evaluating the effects of a specific kinesitherapeutic treatment protocol with duration of 21 days on the functional and biochemical parameters in patients recovering from acute myocardial infarction. The rationale behind this investigation lies in the growing body of evidence suggesting that structured physical activity can positively influence cardiovascular health, functional capacity, and overall well-being. The study conducted once more proves the importance of physical activity on general health and the functionality of the cardiovascular system in particular. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, “HYBRID THINKING”(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2024) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Thyrotoxicosis-Induced Reversible Dilated Cardiomyopathy: A Case Report(AVES YAYINCILIK A.Ş., 2026-01-07); ;Manev, NikolaThyrotoxicosis-induced cardiomyopathy (TCM) is a rare but severe complication of thyrotoxicosis, characterized by significant left ventricular systolic dysfunction. While heart failure (HF) symptoms may be common in patients with thyrotoxicosis, true cardiomyopathy remains uncommon, affecting less than 1% of these individuals. A 27-year-old previously healthy woman who presented with symptoms of severe thyrotoxicosis, including irritability, hair loss, persistent dry cough, hypertension, and tachycardia is reported. Thyroid tests revealed elevated levels of free triiodothyronine and thyroxine, with suppressed thyroid-stimulating hormone. Thiamazole and propranolol therapy were initiated. Two months later, her condition worsened, with fatigue, leg and abdominal swelling, and persistent cough. Echocardiography showed a severely reduced ejection fraction (EF 19%) and dilated cardiac chambers. N-terminal pro–B-type natriuretic peptide levels were elevated. She was managed with diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, and continued thyroid treatment. After 7 days, EF improved to over 40%, with reduced ventricular dimensions. Continued treatment led to progressive recovery. At the 18-month follow-up, echocardiography documented normalized chamber dimensions and preserved EF, confirming complete reversal of TCM. This case highlights the importance of early recognition and intervention, as prompt restoration of thyroid function and appropriate HF management are crucial for reversing cardiac dysfunction and improving outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE ROLE OF SHOCKWAVE INTRAVASCULAR LITHOTRIPSY IN THE TREATMENT OF HEAVILY CALCIFIED CORONARY ARTERY LESIONS: OUR FIRST EXPERIENCE(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-12-17); ;Jovkovski, Aleksandar ;Manev, Nikola; Introduction: Coronary artery disease (CAD) is typically a chronic, progressive, inflammatory disease of the coronary arteries caused by coronary atherosclerosis. Moderate-to-severe calcification is present in up to 30% of patients undergoing coronary angiography (CA). Calcified coronary artery lesions are one of the most complex and challenging lesion subsets in interventional cardiology. Shockwave intravascular lithotripsy (IVL) is a recently introduced calcium-modifying technique for the treatment of concentric, eccentric and nodular calcifications. Case presentation: We present a clinical case of a 73-year-old male complaining of intermittent chest pain. He was a non-smoker with a positive familiar history for CVD. He had previous myocardial infarction and stenting of the right coronary artery (RCA), previous CVI, paroxysmal atrial fibrillation, insulin-dependent type 2 diabetes, heart failure with mildly reduced ejection fraction (HFmrEF) and chronic kidney disease (CKD) stage II/IIIa. CA revealed heavily calcified CAD. A calcified lesion of the left anterior descending artery (LAD) was treated using a 3.0/12 mm Shockwave IVL balloon; and calcium cracks and fractures were confirmed by optical coherence tomography (OCT). We proceeded with an NC balloon and finally treated the lesion with a 3.5/15 mm drug-coated balloon (DCB). The calcified lesion of the RCA was treated with conventional techniques using guiding catheter extension, NC balloons and drug-eluting stent (DES). Conclusion: Heavily calcified coronary artery lesions remain one of the biggest challenges for interventional cardiologists. Shockwave IVL is designed for treatment of all types of heavily calcified lesions using acoustic waves (shock waves). IVL is safe and effective technique that will definitely strengthen the armamentarium for modern treatment of heavily calcified lesions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Wernicke’s Encephalopathy from Hyperemesis Gravidarum. A Case Report(Albanian Society for Trauma and Emergency Surgery, 2024-07-20) ;Dalipi, Teuta; ;Mehmeti, GazmendDalipi, Rezeart - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EMERGING BIOMARKERS AT THE CROSSROADS OF CARDIAC, RENAL, AND HEPATIC DYSFUNCTION: A NEW ERA IN MULTIORGAN RISK STRATIFICATION(Faculty of Medicine, Ss Cyril and Methodius University in Skopje, 2026-03-24); ;Petkovski, Dusan; ;Vranjko, ElifDobjani, Amela - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DERMATOGLYPHIC PATTERNS AMONG STUDENTS IN NORTH MACEDONIA(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2026-03-24); ; ; ; Introduction: Dermatoglyphics is a scientific discipline that studies the epidermal ridge patterns present on the palmar surfaces of the hands, the toes and the plantar surfaces of the feet. Aim. An analysis of individual dermatoglyphic characteristics in healthy medical students of Macedonian and Albanian ethnicity was conducted. Material and methods: The study included 234 healthy students; palm prints were obtained and dermatoglyphic parameters were read, classified and compared with data reported in the dermatoglyphic literature. Imprinting was done by the Cummins and Midlo ink method. The reading and classification of dermatoglyphic patterns were performed according to Henry's system. Results: Ulnar loops were the most prevalent patterns, followed by circular, arcuate and complex patterns, which were present in a small percentage in both genders; radial loop was present only on the second finger in both genders. There were differences on the right hand for the second, fourth and fifth finger, and on the left hand for the third, fourth and fifth finger between males and females. Also, significant differences were found in the third and fourth interdigital spaces and hypothenar area. The triradii distribution formula in females was: a > b > d > c > t; whereas in males it was: a > t > b > c = d. Additional triradii were rare in both genders. The atd angle was within the range of 32ᵒ -55ᵒ in females and 33ᵒ -50ᵒ in males, most often 40ᵒ in both groups. Conclusion: This population-based study have shown similarities and differences in the prevalence of some dermatoglyphic features in males and females among healthy students. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MINIMALLY INVASIVE GLAUCOME SURGERY, TECHNIQUES AND PROCEDURES(Journal of Morphological Sciences, 2024-12-23); ;Pandilov, StefanMuhamedin Rushiti - Some of the metrics are blocked by yourconsent settings
Item type:Publication, WCN26-6392 LONG TERM EFFECTS OF MEDIUM CUT-OFF DIALYSIS MEMBRANES ON MIDDLE AND LARGE MIDDLE UREMIC TOXINS IN PATIENTS ON MAINTENANCE HEMODIALYSIS(Elsevier BV, 2026-04); ; ;Bushljetik, Oliver; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pathohistomorphometric and Immuno-Histologic Changes in Early Arteriovenous Fistula Failure in Patients with Chronic Kidney Disease(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2024-07-15); ; ; ; Popov, ZivkoBackground Hemodialysis is a prevalent treatment for the end-stage chronic kidney disease (CKD) worldwide. The primary arteriovenous fistula (AVF), widely considered the optimal hemodialysis access method, fails to mature in up to two-thirds of the cases. The etiology of the early AVF failure, defined as thrombosis or inability to use within three months post-creation remains less understood, and is influenced by various factors including patient demographics, surgical techniques, and genetic predispositions. Neointimal hyperplasia is a primary histological finding in stenotic lesions leading to the AVF failure. However, there are insufficient data on the cellular phenotypes and the impact of the preexisting CKD-related factors. This study aims to investigate the histological, morphometric, and immunohistochemical alterations in the fistula vein, pre-, peri-, and post-early failure. Materials and Methods Eighty-nine stage 4-5 CKD patients underwent standard preoperative assessment, including the Doppler ultrasound, before a typical radio-cephalic AVF creation. Post-failure, a new AVF was created proximally. The vein specimens were collected during the surgery, processed, and analyzed for morphometric analyses and various cellular markers, including Vimentin, TGF, and Ki 67. Results The study enrolled 89 CKD patients, analyzing various aspects of their condition and AVF failures. The histomorphometric analysis revealed substantial venous luminal stenosis and varied endothelial changes. The immunohistologic analysis showed differential marker expressions pre- and post-AVF creation. Conclusion This study highlights the complexity of the early AVF failures in CKD patients. The medial hypertrophy emerged as a significant preexisting lesion, while the postoperative analyses indicated a shift towards neointimal hyperplasia. The research underscores the nuanced interplay of vascular remodeling, endothelial damage, and cellular proliferation in the AVF outcomes.
