Faculty of Medicine
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Item type:Publication, Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients-An Open-Label Phase II Clinical Trial(MDPI (Multidisciplinary Digital Publishing Institute), 2022-10-09); ; Background: COVID-19 convalescent plasma (CCP) is an important antiviral option for selected patients with COVID-19. Materials and Methods: In this open-label, phase 2, clinical trial conducted from 30 April 2020 till 10 May 2021 in the Republic of North Macedonia, we evaluated the efficacy and safety of CCP in hospitalized patients. Treatment was with a single unit of CCP having an anti-RBD IgG concentration higher than 5 AU/mL. Results: There were 189 patients that completed the study, of which 65 (34.4%) had WHO 8-point clinical progression scale score of 3 (requiring hospital care but not oxygen support), 65 (34.4%) had a score of 4 (hospitalized and requiring supplemental oxygen by mask or nasal prongs), and 59 (31.2%) had a score of 5 (hospitalized and requiring supplemental oxygen by non-invasive ventilation or high-flow oxygen). Mean age was 57 years (range 22−94), 78.5% were males, 80.4% had elevated body mass index, and 70.9% had comorbidity. Following CCP transfusion, we observed clinical improvement with increase rates in oxygenation-free days of 32.3% and 58.5% at 24 h and seven days after CCP transfusion, a decline in WHO scores, and reduced progression to severe disease (only one patient was admitted to ICU after CCP transfusion). Mortality in the entire cohort was 11.6% (22/189). We recorded 0% mortality in WHO score 3 (0/65) and in patients that received CCP transfusion in the first seven days of disease, 4.6% mortality in WHO score 4 (3/65), and 30.5% mortality in WHO score 5 (18/59). Mortality correlated with WHO score (Chi-square 19.3, p < 0.001) and with stay in the ICU (Chi-square 55.526, p ≤ 0.001). No severe adverse events were reported. Conclusions: This study showed that early administration of CCP to patients with moderate disease was a safe and potentially effective treatment for hospitalized COVID-19 patients. The trial was registered at clinicaltrials.gov (NCT04397523). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID-19 and Preexisting Cardiovascular Disease(Lippincott Williams & Wilkins / Wolters Kluwer, 2023-07-14) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PUNCTURE INJURY IN THORACOLUMBAR REGION(Faculty of Medicine, Ss Cyril and Methodius University in Skopje, 2022); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BOUVERT'S SYNDROME: A CASE REPORT(University Ss. Cyril and Methodius in Skopje, 2024); ; Gjoshev, Stojan - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hidden intrapancreatic portal cavernoma by pancreatic cephalic carcinoma Ц an indication for portal vein resection Ц Case Report(Elsevier BV, 2022-11); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RESECTION OF THE LATE RECCURENCE OF PANCREATIC HEAD CARCINOMA AFTER WHIPPLE PROCEDURE IS SAFE, FEASIBLE AND OFFERS LONG-TERM PROGNOSIS IMPROVEMENT(Македонско лекарско друштво = Macedonian medical association, 2023); ; Velimir Shumenkovski - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BEYOND THE LIVER AND LUNGS: AN UNCOMMON CASE OF ISOLATED SPLENIC ECHINOCOCCOSIS(Македонско лекарско друштво = Macedonian medical association, 2025) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, INITIAL EXPERIENCE WITH HEPATOPANCREATODUODENECTOMY IN NORTH MACEDONIA: CASE SERIES AND LITERATURE REVIEW(Македонско лекарско друштво = Macedonian medical association, 2025); ; ; Kolari, Arbijon - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NOVEL HEPATICOJEJUNOSTOMY TECHNIQUE USING THE CYSTIC DUCT CONFLUENCE IN A NARROW COMMON HEPATIC DUCT(Македонско лекарско друштво = Macedonian medical association, 2025); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATION OF STANDARD HEPATICOJEJUNOANASTOMIS AS A SEQUENCE OF RECONSTRUCTION IN RADICAL PANCREATODUODENECTOMY - WHIPPLE PROCEDURE PROSPECTIVE RANDOMIZED SINGLE CENTER CLINICAL STUDY(Македонско лекарско друштво = Macedonian medical association, 2025); ;