Faculty of Medicine

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Access type: UnknownAuthor: search.filters.author.Jordancho Ivanov

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    Early Ultrasound Screening for Fetal Malformations in the Second Pregnancy after Combined Modality Treatment for Hodgkin’s Disease: A Case Report
    (SCVISION Publishers, 2017-11)
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    Jordancho Ivanov
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    ABSTRACT Introduction: Therapeutic progress in HD has led to a high rate of cure, but at the expense of some side effects. Abnormalities reported so far are: cardiac toxicity, pulmonary toxicity, endocrinal failure, second cancers and congenital malformations. Although several studies reported in the literature showed no or slightly increased risk of congenital abnormalities among newborns of women previously treated for Hodgkin’s disease compared with the general population, abnormalities do occur and sometimes they are very odd and difficult. This is the first report of delayed appearance of specific malformations found in the literature. Case Report: We report a case of female patient, 25 years old, macedonian, presented with Hodgkin’s disease, subtype nodular sclerosis, stage IIIA. The patient received chemotherapy according to ABVD protocol – 6 cycles. Thereafter she received mantle field radiation with 3600 cGy. The first and normal pregnancy occurred after 36 months. Second pregnancy occurred 87 months after completion of treatment. At 13th gestational week ultrasound assessment revealed malformations and induced abortion was performed. A male fetus with malformations on the head such as proboscis, cyclopia and omphalocele on the front abdominal wall containing liver and small bowels was found. Conclusion: I consider this case important in bringing the potential late side-effect to the attention of both patients and doctors. They should be alert for the risk of congenital abnormalities in newborns of women previously treated for Hodgkin’s disease, especially with combined modality treatment, and should check for them during pregnancy, at birth, in early childhood, or in adulthood. Thus, odd and difficult malformations could be avoided.
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    PREMATURITY AND LOW BIRTH WEIGHT PARTICIPATION IN NEONATAL DEATHS AT GYNAECOLOGY AND OBSTETRICS CLINIC IN SKOPJE IN THE PERIOD OF SEVEN YEARS
    (Macedonian Association of Anatomists, 2020-12)
    ;
    Jasna Bushinoska
    ;
    Jordancho Ivanov
    Abstract Most of the neonatal deaths at NICU, in the neonatal period of life 0-28 days after delivery are results of preterm births and complications from prematurity. Preterm birth is a birth before 37 g.w. of pregnancy. Neonatal mortality is a death among live- born new-borns in the first four weeks of life after delivery. Prematurity and low birth weight significantly participate in neonatal deaths at NICU. The purpose of the study is to show the participation of prematurity and low birth weight in neonatal mortality, between new-borns admitted and treated at NICU at the GOC-Skopje, in the period of seven years. The retrospective analysis showed the participation of prematurity and low birth weight in neonatal mortality at NICU, at GOC- Skopje in the period of seven years- 2011-2017. The data was collected from the Data basis of NICU and medical histories of new-borns at NICU, during this period. In the period of seven years there were 36706 live-born new-borns at GOC-Skopje. 4810 of them or 13.18% were admitted and treated at NICU. Neonatal mortality at NICU in the seven years period was 912 new-borns, or 19% from all neonates admitted at NICU. Most of them 867, or 95% of neonatal deaths were preterm births or new-borns delivered before 37 g.w. of pregnancy. The leading causes for neonatal death in new-borns treated at NICU were complications due to prematurity and low birth weight in new-borns, in the period of seven years 2011-2017. Prematurity and low birth weight participate in the most of neonatal deaths at NICU and should be prevented in the future.