Faculty of Medicine
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Item type:Publication, The role of rapid chromatographic immunoassay tests in acute poisoning: two case reports and literature overview(Edizioni Minerva Medica, 2026-03-22); ; ; ; This report through the presentation of two case studies highlights the common problem with false-positive urine drug screen faced by many physicians to the emergency and toxicology departments. Case 1: a 29-year-old male patient was admitted after acute poisoning with analgesics/antipyretics (Caffetin Cold, Caffetin); diazepam; amlopin. Case 2: a 56-year-old female patient was admitted with impaired consciousness. According to the data obtained from the patient’s family they suspected that she took the following drugs: Zanfexa, Zalasta and Diazepam. A rapid chromatographic immunoassay urine test was performed in both patients for the following substances: opiates, amphetamines, metamphetamine, MDMA (3,4-methylenedioxymethamphetamine), oxycodone, phencyclidine, cocaine, methadone, barbiturates, cannabinoids, benzodiazepines, tricyclic antidepressants, and tramadol. Case 1 was positive for opiates, benzodiazepines and amphetamines. Gas chromatography mass spectrometry and high-performance liquid chromatography were used and confirmed the presence of caffeine, codeine, paracetamol, propyphenazone, pseudoephedrine, dextromethorphan, nordazepam, ramipril and amlodipine in urine sample. Case 2 was positive for tramadol and benzodiazepines. Gas chromatography mass spectrometry was used and confirmed the presence of venlafaxine, its metabolites and nordazepam in serum and urine samples. If a false-positive urine screen result is suspected, nonimmunologic techniques, such as gas chromatography/mass spectrometry or high-performance liquid chromatography, are necessary for confirmation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Late emergence of myasthenia gravis complicating envenoming by Vipera ammodytes(Elsevier BV, 2026-10-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, False positive drug test in patient with acute poisoning(Македонско лекарско друштво = Macedonian Medical Association, 2025-04-07); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Plasmapheresis in managing copper sulphate poisoning(Informa UK Limited, 2025-05-27); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, D-dimer as a prognostic biomarker of the outcome in acute corrosive poisoning(2025-05-27); ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Fatal Case of Opioid Overdose with Somatic Comorbidity: A Case Report and Review(Türkiye Klinikleri, 2025-03-21); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Corrosive poisonings during the COVID-19 pandemic: trends and demographic shifts in the pre- and early vaccination periods (2020–2021)(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2025-09-15); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Poisonings with Endemic Plants in Macedonia(Macedonian Association of Internal Medicine, 2022-05); ; ; Jurukov, Irena - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2023-12); ; ; Initial studies on impaired glucose-insulin homeostasis in heroin dependents have not defined the impact of concomitant hepatitis C infection (HCV), which has been strongly associated with the development of insulin resistanceand metabolic syndrome (MS). The aim of our study was to evaluate the association of heroin dependence with glucose-insulin homeostasis and MS in heroin dependents with HCV seronegativity. Materials and methods: The study was prospective and cross-sectional, including 160 heroin dependents compared to a control group of 60 participants.MS was diagnosed using International Diabetes Federation criteria. The homeostatic model assessment for insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-%B) were used for assessing insulin resistance and β-cell function of pancreas. Results: MS was detected in 9.32% of heroin addicts. Heroin dependents with MS compared to dependents without MS were older, had higher BMI, waist circumference and significantly higher systolic and diastolic blood pressure, increased triglycerides (F=8.233, df=2, p<0.001), apoB (F=8.154, df=2, p=0.001), and reduced HDL-C (F=25.926, df=2, p<0.001) and apoA-I (F=16.406, df=2, p<0.001), significantly increased inuslinemia (F=4.928, df=2, p<0.05), insulin resistance-HOMA-IR (F=4,928, df=2, p<0,05) and insignificantly increased pancreatic β-cell function (194.66 ±224.05) (F=2.461, df=2, p>0.05). Conclusions: Insulin resistance and МS, independent of HCV, was also registered in heroin dependence. Timely recognition will enable more successful treatment of comorbidities and illicit drug dependence.