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Title: Myasthenia Gravis and Associated Diseases
Authors: Tanovska, Nikolina 
Novotni, Gabriela
Sazdova-Burneska, Slobodanka
Kuzmanovski, I
Boshkovski, Bojan
Kondov, Goran 
Jovanovski-Srceva, Marija
Kokareva, Anita
Isjanovska, Rozalinda 
Keywords: myasthenia gravis
Autoimmune disease
Associated condition
Issue Date: 5-Mar-2018
Publisher: Scientific foundation SPIROSKI
Journal: Open Access Macedonian Journal of Medical Sciences 
Abstract: BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases.AIM: to determine the presence of other associated diseases in patients with MG.METHOD: A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.RESULTS: The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins.CONCLUSION: Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.</jats:p>
DOI: 10.3889/oamjms.2018.110
Appears in Collections:Faculty of Medicine: Journal Articles

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