Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/8658
Title: ESTRADIOL: MECHANISM OF CARDIORENAL PROTECTION
Authors: Petrovska, Sunchica 
Manchevska, Sanja 
Dejanova, Beti 
J. Pluncevic Gligoroska 
Keywords: estrogens,
premenopause,
vascular wall,
cardiomyocytes
Issue Date: 2017
Publisher: Faculty of Physical Education, Sport and Health in Skopje
Journal: Research in Physical Education, Sport and Health
Abstract: Premenopausal women have a decreased incidence of cardiovascular disease and a decreased rate of progression of renal disease. With the onset of menopause, however, decreased synthesis of 17β-estradiol (estradiol) is accompanied by an increased incidence of cardiovascular disorders and accelerated progression of renal diseases. The glomerulus and the vascular wall are not static, and components of these structures dynamically increase, decrease, or reorganize in response to physiological and pathological stimuli. Although multiple cellular and biochemical processes are involved in glomerular and vascular remodelling, glomerular mesangial cells (GMCs) in the kidney and smooth muscle cells (VSMC) and endothelial cells in the vasculature are the final common pathway for dynamic changes in glomerular and vascular wall structure. Estradiol may induce protective effects on the renal and cardiovascular system by altering VSMC, GMC, or endothelial cell biology so as to prevent glomerular and vascular remodelling. The purpose of this review is to provide an overview of the participating mechanisms in this regard, as well as the mechanism of estradiol signalling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection.
URI: http://hdl.handle.net/20.500.12188/8658
Appears in Collections:Faculty of Medicine: Journal Articles

Files in This Item:
File Description SizeFormat 
PESH17SUNCE.pdf180.16 kBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

8
checked on Jan 18, 2021

Download(s)

1
checked on Jan 18, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.