The Influence of Smoking on the Variations in Carboxyhemoglobin and Methemoglobin During Urologic Surgery

Journal
Medical archives (Sarajevo, Bosnia and Herzegovina)
Date Issued
2017-06
Author(s)
Mojsova-Mijovska, Maja
Taleska, Gordana
Simeonov, Risto
DOI
10.5455/medarh.2017.71.178-182
Abstract
Surgery is supposed to modulate the production of carbon monoxide by the reduction of heme oxygenase activity or transcriptional regulation of inducible heme oxygenase. On the other hand, the inhalation of tobacco smoke can substantially raise the level of carboxyhemoglobin in the blood. Furthermore, methemoglobin is maintained at a constant level. However, excessive production of methemoglobin relative to total methemoglobin reductase activity results in methemoglobin increase.