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Authors: Sonja Kuzmanovska 
Majstorov, Venjamin 
Miladinova, Daniela 
Jovanovska, Viktorija
Atanasova Boshku, Aleksandra
Shabani, Ajla
Milevska Kostova, Neda
Vaskova, Olivija 
Karanfilski, Borislav
Keywords: pregnancy
iodine status
thyroid status
iodine supplementation
sustainable iodine sufficiency
Issue Date: 2019
Project: Thyroid and iodine status in pregnant women
Journal: Macedonian Medical Preview
Abstract: Background: Optimal iodine intake is essential for proper function of the thyroid in pregnancy, affecting thus the foetal development. Recent data worldwide have revealed insufficient iodine intake in pregnant women in certain countries with confirmed iodine sufficiency and raise the issue of iodine supplementation in this population. The objective of the study was to determine the effects of the iodine supplementation in pregnant women (PW) on their thyroid status and compare the findings with the data of pregnant women without iodine supplementation, all living under iodine sufficiency of general population. Material and Methods: The case control study was performed on total 543 PW (aged 15 – 40 years), 267 of which were taking iodine supplements. Iodine status was assessed as median urinary concentration and thyroid function tests (TFTs) were performed by chemiluminescent immunoassays. Data analysis was performed by descriptive and nonparametric statistics. Results: The overall median urinary iodine concentration (UIC) in PW was 167,5 μg/L. The median value of the group with iodine supplementation was higher compared to non-supplementation group (180,5 μg/L vs 160,2 μg/L), but the difference was not statistically significant. The median value was higher for thyroid stimulating hormone (TSH) in the group of PW with iodine supplementation (1,8 mIU/L vs. 1,6 mIU/L), while for thyroglobulin (Tg) in the group without iodine supplementation (11,4 μg/L vs. 10,5 μg/L). The difference in free thyroxine (FT4) results between the two groups was not statistically significant. Conclusions: Living in a long-term iodine sufficient region, PW on iodine supplementation with 150 μg/day remained euthyroid, without evidence of increased incidence of iodine-induced thyroid disorders.
ISSN: 0025-1097
Appears in Collections:Faculty of Medicine: Journal Articles

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