Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/8013
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dc.contributor.authorSonja Kuzmanovskaen_US
dc.contributor.authorMajstorov, Venjaminen_US
dc.contributor.authorMiladinova, Danielaen_US
dc.contributor.authorJovanovska, Viktorijaen_US
dc.contributor.authorAtanasova Boshku, Aleksandraen_US
dc.contributor.authorShabani, Ajlaen_US
dc.contributor.authorMilevska Kostova, Nedaen_US
dc.contributor.authorVaskova, Olivijaen_US
dc.contributor.authorKaranfilski, Borislaven_US
dc.date.accessioned2020-05-08T12:19:18Z-
dc.date.available2020-05-08T12:19:18Z-
dc.date.issued2019-
dc.identifier.issn0025-1097-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/8013-
dc.description.abstractBackground: Optimal iodine intake is essential for proper function of the thyroid in pregnancy, affecting thus the foetal development. Recent data worldwide have revealed insufficient iodine intake in pregnant women in certain countries with confirmed iodine sufficiency and raise the issue of iodine supplementation in this population. The objective of the study was to determine the effects of the iodine supplementation in pregnant women (PW) on their thyroid status and compare the findings with the data of pregnant women without iodine supplementation, all living under iodine sufficiency of general population. Material and Methods: The case control study was performed on total 543 PW (aged 15 – 40 years), 267 of which were taking iodine supplements. Iodine status was assessed as median urinary concentration and thyroid function tests (TFTs) were performed by chemiluminescent immunoassays. Data analysis was performed by descriptive and nonparametric statistics. Results: The overall median urinary iodine concentration (UIC) in PW was 167,5 μg/L. The median value of the group with iodine supplementation was higher compared to non-supplementation group (180,5 μg/L vs 160,2 μg/L), but the difference was not statistically significant. The median value was higher for thyroid stimulating hormone (TSH) in the group of PW with iodine supplementation (1,8 mIU/L vs. 1,6 mIU/L), while for thyroglobulin (Tg) in the group without iodine supplementation (11,4 μg/L vs. 10,5 μg/L). The difference in free thyroxine (FT4) results between the two groups was not statistically significant. Conclusions: Living in a long-term iodine sufficient region, PW on iodine supplementation with 150 μg/day remained euthyroid, without evidence of increased incidence of iodine-induced thyroid disorders.en_US
dc.language.isoenen_US
dc.relationThyroid and iodine status in pregnant womenen_US
dc.relation.ispartofMacedonian Medical Previewen_US
dc.subjectpregnancyen_US
dc.subjectiodine statusen_US
dc.subjectthyroid statusen_US
dc.subjectiodine supplementationen_US
dc.subjectsustainable iodine sufficiencyen_US
dc.titleIODINE SUPPLEMENTATION AND THYROID STATUS IN HEALTHY PREGNANT WOMEN IN IODINE-REPLETE REGIONen_US
dc.typeArticleen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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