Spiroski, Mirko
Preferred name
Spiroski, Mirko
Official Name
Spiroski, Mirko
Translated Name
Мирко Спировски
Alternative Name
Мирко Спироски
Мирко Спировски
М. Спироски
М. Спировски
M. Spiroski
M. Spirovski
Mirko Z. Spiroski
Mirko Z. Spirovski
Spiroski, M.
Spirovski, M.
Main Affiliation
Email
mspiroski@yahoo.com
mspiroski@id-press.eu
Researcher ID
https://publons.com/researcher/F-7606-2012/
70 results
Now showing 1 - 10 of 70
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Item type:Publication, Total IgE Distribution in Food Allergy Suspected Patients in Republic of Macedonia (2001-2011)(ID Design 2012/DOOEL Skopje, 2015-06-15); ; ; ; IgE may be considered the hallmark of allergic disorders. It is easily detected in serum and can be measured as total IgE and as allergen-specific IgE. In fact, the serum IgE assay is used to diagnose an allergy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association between 22 cytokine gene polymorphisms and dilated cardiomyopathy in Macedonian patients(2009-11) ;Spiroska, Vera; ;Antov, Slobodan; Inflammation is an important component in the pathogenesis of many cardiovascular diseases and one of the commonest mechanisms in cardiomyopathy. There have been several studies on the cytokine polymorphism and dilated cardiomyopathy (DCM), but the results obtained were contradictory. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia(ID Design 2012/DOOEL Skopje, 2016-12-15) ;Kamberi, Bajram ;Kamberi, FarijeAcute first-ever ischemic stroke (FIS) is a heterogeneous, polygenic disorder. The contribution of vascular genetic variants as inherited causes of ischemic stroke has remained controversial. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Distribution of CYP2C9 and VKORC1 Gene Polymorphisms in Healthy Macedonian Male Population(ID Design 2012/Scientific Foundation SPIROSKI, 2013-12-15); ; ; ;Aleksandar Senev<jats:p>Background: Distribution of CYP2C9 and VKORC1 gene polymorphisms may vary significantly among different ethnic groups, and eventually influence the variation in drug metabolism or even failure.Objective: The aim of this study was to evaluate the prevalence of CYP2C9 and VKORC1 alleles in the healthy population of Republic of Macedonia compared to the global geographic data reported from different ethnic populations. Also, to genotype CYP2C9 and VKORC1 genes and eventually to divide individuals in poor, extensive, or intermediate metabolizer.Material and Methods: Blood samples were collected after signing written consent, DNA was isolated from peripheral blood, and CYP2C9 and VKORC1 genes were typed (n=124). Genotyping was performed by commercially available kits (GeneID GmbH, Strassberg, Germany, AID Diagnostica), based on the method of polymerase chain reaction with a subsequent hybridization. The population genetics analysis package, PyPop ver. 0.6.0, was used for analysis of the data.Results: The frequency of alleles varies from 0.931 for CYP2C9*3 to 0.109 for CYP2C9*2 indicating common “wild type” allele in those genes. The frequency ranges spanned ~50% for each allele of VKORC1 gene, indicating no common “wild type” allele in this gene. Test of neutrality showed significant negative value for VKORC1 polymorphism that indicates balancing selection operating on the alleles at that locus. All polymorphisms of CYP2C9*2, CYP2C9*3 and VKORC1 showed a good fit with Hardy-Weinberg expectations.Conclusion: The results of polymorphic alleles of CYP2C9 and VKORC1 genes in Macedonian population can be used for the variation in drug metabolism studies as well for adapting dosage regimes for oral anticoagulant therapies.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Правата на лицата со аутизам во Република Македонија(Македонско научно здружение за аутизам, 2002); ;Ајдински, Љупчо - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gene polymorphisms of 22 cytokines in Macedonian children with atopic dermatitis(2012-03); ;Peova, Sonja; Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals. Susceptible cytokine polymorphisms for AD for eleven genotypes (IL-4 -33/T:T IL-4 -1098/G:G, TGFbeta cdn25C:G, IL-4 -1098/T:T, IL-1alpha -889/C:T, IL-2 +166/T:T, IL-1beta -511/C:T, IL-12 -1188/C:T, IL-10 -1082/A:G, IL-1beta +3962/C:T, IFNgamma +874/A:T), five diplotypes, six haplotypes, and for alleles were found. Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4 -1098/G:T, TGFbeta cdn25/G:G, IL-4 -33/C:C, IL-1alpha -889/C:C, IFNgamma +874/A:A, IL-10 -1082/A:A, IL-1beta -511/C:C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. We concluded that several cytokine polymorphisms are protective, or susceptible associated with AD in population of Macedonians. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians(2009-07); ;Trajchevska, Mirjana ;Arsov, Todor; Strezova, AnaTo examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against tuberculosis (TB) in Macedonians. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Имунна недостатъчност и супресия на имунната система у деца с аутизъм(2002); Etiology and pathogenesis of autism are still unknown. The disorder may be a constellation of multiple factors: neural, genetic, immune, environmental, and biochemical. The critically important job of fighting off infections falls to our immune system. Recent research by several scientists has shown that children with autism have serious abnormalities in this all- important system. Defects in the immune system may lead to overgrowth of the intestinal tract with organisms like yeast. The role of immunizations in causing immune deficiencies is very important. The aim of this article is to shown immunodeficient conditions in children with autism and possibility to their therapeutically solution. Autism is characterized with different types of immunodeficiency: myeloperoxidase deficiency, severe combined immunodeficiency disease, selective IgA deficiency, IgG subclass deficiency, and complement deficiency. Here are presented several types of immunotherapeutic methods such as: gamma globulin therapy, transfer factor therapy, treatment with IL-2, enzyme-potentiated desensitization, and two other kinds of pharmacotherapy of autism. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Distribution of Killer Cell Immunoglobulin-Like Receptor Genes in Albanians from Republic of Macedonia(ID Design 2012/Scienfitic Foundation SPIROSKI, 2015-02-19); ;Eli Djulejic; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The effect of a small dose of ketamine on postoperative analgesia and cytokine changes after laparoscopic cholecystectomy(Macedonian Academy of Sciences and Arts, 2012); ; ; ;Nikolova Todorova, Z.In this study we assesed the effect of a small dose of ketamine on the production of TNFα, IL-1β and IL-6 and the postoperative pain in patients undergoing laparoscopic cholecystectomy.
