Simeonovski, Viktor
Preferred name
Simeonovski, Viktor
Official Name
Simeonovski, Viktor
18 results
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Item type:Publication, How to prevent skin damage from air pollution. Part 1: Exposure assessment(Wiley, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hydroxyurea Associated Cutaneous Lesions: A Case Report(Scientific Foundation SPIROSKI, 2018-08-20); ; ; ; Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, How to prevent skin damage from air pollution part 2: Current treatment options(Hindawi Limited, 2021-11); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Use of SEM/EDX methods for the analysis of ambient particulate matter adhering to the skin surface(Wiley, 2022-08); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Back to the basics: Propolis and COVID-19(Wiley Online Library, 2020-07); ; The epidemiological burden of COVID-19 is a healthcare challenge throughout the world, not only in terms of testing the limits of medical capacities, but also as an enigma considering preventive strategies and methods. The upper respiratory tract mucosa is the first line of defense, as a physical barrier, as well as through multiple innate and adaptive immune mechanisms which are crucial for efficient antiviral responses. Identifying methods able to reduce or prevent colonization, viral adhesion, and promote virus shedding on mucous membranes or have the ability to inactivate pathogens and thus reduce virus dose and/or increase immune response would be essential in the management of COVID-19 outbreak and help in flattening the curve. We review the effects of propolis, an old remedy with proven antiviral properties, as a possible low-cost inhibitor of SARS-CoV-2 in the oropharyngeal niche, prophylaxis, or adjuvant therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DISRUPTION OF HAIR FOLLICLE IMMUNE PRIVILEGE IN ALOPECIA AREATA: ENIGMATIC MECHANISMS AND EMERGING CONCEPTS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-12-12); ; ; ; Mircheska Arsovska, ElenaImmune privilege (IP) is a specialized immunological state that protects certain tissues, including the hair follicle (HF), from immune-mediated destruction. The maintenance of hair follicle immune privilege (HFIP) is crucial for uninterrupted hair growth and is mediated by several mechanisms. These include the downregulation of major histocompatibility complex (MHC) class I molecules, the secretion of immunosuppressive cytokines such as transforming growth factor-beta (TGF-β) and alpha-melanocyte-stimulating hormone (α-MSH), and the recruitment of regulatory immune cells that suppress pro-inflammatory responses. Additionally, the blood-hair follicle barrier limits immune cell infiltration, further preserving immune privilege. However, in alopecia areata (AA), HFIP collapses triggering an autoimmune attack against follicular structures. This breakdown is marked by increased antigen presentation, heightened expression of MHC class I and II molecules, and an influx of autoreactive cytotoxic CD8+ T cells. These T cells, particularly those expressing the NKG2D receptor, recognize stress-induced ligands on follicular keratinocytes and initiate a cytotoxic response. Interferon-gamma (IFN-γ) and interleukin-15 (IL-15) play central roles in amplifying inflammation by activating the JAK-STAT signaling pathway, further promoting immune cell infiltration and follicular destruction. Additional immune cells, including natural killer cells, dendritic cells, and macrophages, contribute to disease pathogenesis by enhancing antigen presentation and sustaining the inflammatory cascade. Given the central role of HFIP collapse in AA, therapeutic strategies aimed at restoring immune privilege represent a promising avenue for long-term disease management. Future research should focus on identifying key molecular regulators of HFIP and developing targeted interventions to re-establish immune tolerance within the hair follicle. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric case of lichen planus pigmentosus inversus successfully treated with narrow band ultraviolet B phototherapy(Hindawi Limited/Wiley, 2020-11); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric case of lichen planus pigmentosus inversus successfully treated with narrow band ultraviolet B phototherapy(Wiley Online Library, 2020); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance(ID-Design/Scientific foundation SPIROSKI, 2018-03-15); ; ; ;