Risteski, Vladimir
Preferred name
Risteski, Vladimir
Official Name
Risteski, Vladimir
Translated Name
Vladimir Risteski
Main Affiliation
10 results
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Item type:Publication, COLLAPSING GLOMERULOPATHY-RARE VARIANT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS-CASE REPORT(Македонско лекарско друштво = Macedonian medical association, 2021); ; ; ; Focal segmental glomerulosclerosis (FSGS) is classified into five variants, with the collapsing variant being the most rare one. However, the number of idiopathic cases is increasing and the presentation becoming more routine. We report the case of a 77-year-old female patient, with nephrotic syndrome and histopathologic features of glomerular capillary collapse. She presented with chronic renal failure with serum creatinine-126…154…174 μmol/L. Nephrotic syndrome with feet and ankles edema, progressively extended, at first failed to respond to diuretic therapy. The level of total serum protein fraction was 54g/l, albumin-29…24…28g/L. Urinalysis demonstrated proteinuria 7.8 g/l… 6.15g/L and 12.3 g/24 h. Presence of 25-30 erythrocytes and 2-3 leukocytes in urine sediment was also noticed. Renal biopsy was performed to determinate the presence of glomerular disease. The histopathological analysis showed fibrously thickened Bowman’s membrane, with discretely thickened glomerular basal membrane and collapsed vascular lumen on TEM analysis. The treatment of the patient included corticosteroids, angiotensin-converting enzyme inhibitor and lipid lowering agents, which resulted in lowering of the proteinuria, followed by withdrawal of the edema. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DIAGNOSTIC AND THERAPEUTIC MODALITIES IN THE MANAGEMENT OF A PATIENT WITH OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN)-CASE REPORT AND REVIEW(University Ss. Cyril and Methodius in Skopje, 2022); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Rectal Metastasis from Early-Stage Endometrial Carcinoma Not Associated with Endometriosis: A Case Report and Literature Review(Kurume University School of Medicine, 2025-11-13); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Serrated lesions and polyps of colon(Macedonian Society of Gastroenterohepatology, 2023-05); ; Introduction: Serrated lesions and polyps are characterized by the unique architectural pattern of epithelial infoldings into the gland lumen creating a sawtooth (“serrated”) type appearance. Most serrated polyps are asymptomatic and therefore are incidental endoscopic finding. There are 4 main histologic types: hyperplastic polyps, sessile serrated lesion, sessile serrated lesion with dysplasia and traditional serrated adenoma. As many as 30% of colorectal carcinomas arise from serrated neoplasia pathway. Material and methods: Our study analyzed serrated lesions in a one-year period (2022) diagnosed at Institute of pathology, Faculty of medicine in Skopje. Polypectomies were performed at the University Clinic of Gastroenterohepatology in Skopje. All polyps were formalin fixed, paraffin embedded and the sections were routinely stained with HE. Results: We had 99 cases of serrated polyps of colon of which 49 cases were hyperplastic polyps and 50 were sessile serrated lesions. Twenty-seven cases of hyperplastic polyps were males and 22 were females. Thirty-one males had sessile serrated lesions and 19 were females. There were 26 cases of serrated lesions with dysplasia and 24 without dysplasia. Sixteen patients had associated another type of lesion, the most common was conventional tubulovillous adenoma. Conclusion: Serrated lesions in our study were more common in males. Small hyperplastic polyps in distal colon have no malignant potential. Dysplasia was found in almost half of the cases with serrated lesions. Although most of the serrated lesions contain no dysplasia, missing serrated polyp with dysplasia on endoscopy may increase the risk for postcolonoscopy cancer. Follow up intervals are recommended especially in large serrated polyps (>1cm) because of the risk for colorectal carcinoma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A review of the main placental histopathological findings in SARS-CoV-2 infection: analysis of COVID 19 positive patients - single center experience(Wiley, 2022-10); ; ; ; Background: COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuring pandemic. In so far postulated available literature there is a lack of clarity on the exact mechanism how the SARS-CoV-2 virus acts on the placenta. There is a direct effect on the placenta which leads to hypoxia and an indirect effect that is reflected through proinflammatory responses. Aims: To emphasize the spectrum of histopathological and transmission electron microscopy changes in the placenta of COVID infected pregnant women. Methods: The current study was designed as a prospective study on 39 pregnant women with SARSCoV-2 confirmed infection on nasopharyngeal samples. Gross dissection sampling was performed according to Amsterdam Placental criteria. The standard procedure of paraffin embedded section, stained with H&E was routinely used. Moreover the tissue was stained with immunohistochemistry to present the inflammatory response of the placenta, with the following antibodies: CD3, CD20 and CD68. Results & Conclusions: Histological studies of placental tissue revealed the presence of maternal vascular malperfusion (MVMs) or foetal vascular malperfusion (FVMs) lesions and mild inflammatory lesions. The most prevalent histopathological changes were decidual arteriopathy and increased perivillous f ibrin deposition. Ultrastructural analyses showed spherical-like coronavirus particleswithanelectron intermediate-density core as well projections from the surface as spike-like structures in the syncytiotrophoblasts. In conclusion, there are significant histomorphological changes that indicate maternal malperfusion. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chorangioma of placenta: single center analysis(Wiley, 2022-10); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunohistochemical expression of ER, PR and AR in papillary thyroid carcinoma(Springer, 2024-09); ; Background & objectives: From all types of thyroid carcinomas, papillary thyroid carcinoma (PTC) is the most common type. The present study aimed at evaluating the immunohistochemical expression of estrogen receptors (ERs), progesterone receptors (PRs) and androgen receptors (ARs) in PTC compared to goiter. Methods: The retrospective study included 12 cases of PTC and 6 cases of goiter. The cases were diagnosed in the period between December 2020 and March 2021. All of them were retrieved from our database and immunohistochemical staining of formalin fixed paraffin embedded tissues was performed, for ERs, PRs and ARs. Results: From twelve cases of PTC, three were male and nine were female with age range from 19 to 72. All of the goiter cases were female patients, with age range from 34 to 64. Six out of twelve PTC cases were positive for ER in comparison to two out of six goiter cases with a statistically significant difference (p < 0,05). Regarding PR, eight out of twelve PTC cases were focaly positive, and all of the goiter cases were negative. Ten out of twelve cases of PTC were positive for AR, in comparison to one out of six goiter cases with a statistically significant difference (p < 0,05). Conclusion: The results of the present study indicate that malignant cells in PTC express ER, PR and especially AR, in comparison to goiter. That is suggesting that these hormonal receptors may play a role in thyroid cancer tumorigenesis, and that these patients may benefit from hormonal therapy, which should be verified in further studies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A clinicopathological study of invasive apocrine carcinoma of the breast: a single centre experience(Springer, 2024-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Inflammatory myofibroblastic tumor of the appendix(Serbian Pathologists and Cytologists Association, 2022-05); ; Inflammatory myofibroblastic tumor (IMT), also called inflammatory pseudotumor is a rare disease of mesenchymal origin, first described in 1937. Cases of IMT involving the appendix are exceptional, and they can mimic malignant appendicular tumors. Case report: A 25-year-old woman presented to the emergency department with pain in her right lower abdomen for three days. This was associated with increased body temperature and nausea. Other clinical findings included acute abdomen and laboratory analysis with mildly elevated inflammatory markers. No past history of serious illnesses or abdominal surgery. Because of the lack of specific clinical or imaging signs, IMT still offers a great deal of diagnostic challenge. The macroscopic examination of the appendix revealed a surgical specimen of 5.0x2 cm. The tip of the appendix was distended by mucinous material and had signs of acute appendicitis. Histological examination of the specimen stained with hematoxylin and eosin, revealed a mass showing fibroblastic proliferation accompanied by a dense inflammatory infiltrate in the mucosa and a clear widening of the submucosa. A few areas showed myxoid changes with spindle cells, alternating with polyclonal plasma cells and lymphocytes. Immunohistochemical analysis showed positivity for vimentin and partial positivity for CD68, SMA and desmin. Conclusion: Awareness of this type of tumor in the differential diagnosis of appendiceal masses, avoids overtreatment, and highlights the need of long-term follow-up regarding the tendency for local recurrence and small risk of distant metastasis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, POTENTIAL PATHOGENIC VARIANTS IN FANCM AND MUTYH GENES AND INTERGENIC REGIONS TO BREAST CANCER RISK(2025-10-01); ; ;