Igor Aluloski
Preferred name
Igor Aluloski
Official Name
Igor Aluloski
Translated Name
Aluloski
Alternative Name
Aluloski, Igor
Igor, Aluloski
Алулоски, Игор
Aluloski I.
Alulovski I.
I. Aluloski
Алулоски И.
Алулоски Игор
И. Алулоски
Алуловски И.
Email
igor.aluloski@gmail.com
33 results
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Item type:Publication, SERTOLI-LEYDIG CELL TUMOR OF THE OVARY AS AN INCIDENTAL FINDING IN A PATIENT UNDERGOING HYSTERECTOMY DUE TO RECURRENT ABNORMAL UTERINE BLEEDING(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; ; Sertoli-Leydig cell tumor (SLCT) of the ovary is a rare neoplasm that accounts for only 0.5% of all primary ovarian neoplasms. Clinical and histopathological presentations of the tumor are different, which makes diagnosis and treatment difficult. We present a case of a 67-year-old female patient, who presented at the University Clinic for Gynecology and Obstetrics with abnormal uterine bleeding. Explorative curettage was performed for the second time after 1 year, with a histopathological finding of endometrial hyperplasia. The patient underwent an excision of a lung tumor 2 years ago, with a histopathological finding of synovial sarcoma of the lungs, after which she received adjuvant chemotherapy. On transvaginal ultrasonography, the patient had no suspicious pathological findings on the uterus and ovaries. Laboratory tests of tumor markers did not show any elevation. Due to recurrent abnormal bleeding from the uterus, the patient underwent an abdominal hysterectomy with bilateral adnexectomy. Histopathology: Sertoli-Leydig tumor of the right ovary with retiform histoarchitectonics, stage IA and atypical endometrial hyperplasia. Sertoli-Leydig cell tumors have a relatively good prognosis, but their management, surgical treatment and postoperative follow-up due to their rarity is a challenge even today. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EP778 The role of the E-cadherin/β-catenin signal transduction pathway in the prognosis of advanced stage high-grade serous ovarian/fallopian tube cancer(BMJ Publishing Group Ltd, 2019-11); ; ; ; Introduction/Background The aim of the study was to evaluate the correlation between E-cadherin/β-catenin expression and the clinical and pathological parameters that influence the overall survival rate in patients with advanced stage high-grade serous ovarian/fallopian tube cancer Methodology We performed a retrospective cohort study on patients that underwent primary debulking surgery at the University Clinic of Gynecology and Obstetrics, University ‘Ss. Cyril and Methodius’, Skopje, Republic of North Macedonia between January 2010 and December 2015. The following disease characteristics were analyzed: age, stage, nuclear and tumor grade, lymphovascular invasion, the extent of primary debulking, platinum-based chemotherapy resistance and overall survival. Further, we analyzed the expression of E-cadherin/β-catenin by preforming immunohistochemical staining on deparaffinized and rehydrated tissue specimens with specific monoclonal antibodies. Results A total of 84 patients with primary ovarian and 9 patients with primary fallopian tube cancer met the inclusion criteria. The overall survival of patients in the analyzed cohort was 46 months (95% CI 38–53 months). The residual tumor volume after primary debulking surgery was an independent bad prognostic factor with HR=5.32 (p<0.001). The low frequency of expression as well as the weak staining for E-cadherin were independent bad prognostic factors for the survival of these patients with HR=2.7 (p=0.05) and HR=3.38 (p=0.04), respectively. The univariate analysis also identified that the low frequency of expression and weak staining for β-catenin were bad prognostic factors, but the significance was lost in the multivariate analysis. Conclusion In this study, we identified that the residual tumor volume after primary debulking surgery and the low frequency of expression and weak staining for E-cadherin were independent, statistically significant bad prognostic factors for the overall survival of patients with advanced stage high-grade serous ovarian/fallopian tube cancer. Beta catenin expression was not found to be an independent prognostic factor in the multivariate analysis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Therapeutic Resistance In Synchronous Endometrioid Carcinomas: A Case Report With A Pathogenic Germline Mutation In PMS2(Elsevier BV, 2025-02); ; ; ; The occurrence of synchronous malignancies, particularly endometrial and ovarian cancers, presents a notable clinical challenge, with studies indicating that approximately 2-10% of women diagnosed with ovarian cancer also present with endometrial carcinoma. Mismatch repair (MMR) genes, including PMS2, play a crucial role in the pathogenesis of these cancers, as mutations in MMR genes are associated with increased susceptibility to various malignancies. Understanding these genetic factors is essential for effective treatment approaches. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Evaluation of Sentinel Lymph Node Biopsy Using Radiocolloid in First Stage Endometrial Cancer(Galenos Yayinevi, 2023-06-20); ; ; Detection of a sentinel lymph node (SLN) in patients with endometrial cancer (EC) reduces the rate of unnecessary systemic lymph dissection. The aim of this study was to assess the SLN detection rate, accuracy of the method using Tc-99m-SENTI-SCINT and the rate of metastatic nodal involvement in patients with preoperative first stage EC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Factors That Influence Surgical Margin State in Patients Undergoing Cold Knife Conization - A Single Center Experience(Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2017-12-01); ; ; ; To evaluate the factors that influence the surgical margin state in patients undergoing cold knife conization at the University Clinic of Gynecology and Obstetrics in Skopje, Republic of Macedonia Materials and methods: We have retrospectively analyzed the medical records of all patients that underwent a cold knife conization at our Clinic in 2015. We cross-referenced the surgical margin state with the histopathological diagnosis (LSIL, HSIL or micro-invasive/invasive cancer), menopausal status of the patients, number of pregnancies, surgeon experience, operating time and cone depth. The data was analyzed with the Chi square test, Fisher's exact test for categorical data and Student's T test for continuous data and univariate and multivariate logistical regressions were performed. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RELATIONSHIP OF IMMUNOHISTOCHEMICAL EXPRESSION OF MISMATCH REPAIR GENE PRODUCTS AND CLINICOPATHOLOGICAL FEATURES IN PATIENTS WITH LOW-GRADE ENDOMETRIAL CANCER(Macedonian Association of Anatomists and Morphologists, 2024); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute appendicitis in the third trimester of a pregnancy finished with spontaneous vaginal delivery(Asclepius, 2018); ; ; Acute appendicitis is the most common surgical problem occurring during pregnancy. Its incidence is more common in the second trimester and is confirmed in 1/1000 pregnancies. Clinical manifestations of acute appendicitis in pregnant patients are generally very similar to non- pregnant patients. We present, here, the case of a 29-year-old pregnant patient at 35+4 weeks of gestation with the signs of acute appendicitis. The patient underwent a successful open appendectomy of her perforated appendix, without performing a cesarean section (CS) at the same time. 5 weeks postoperatively, at term, labor was induced with vaginal prostaglandins and the patient delivered a healthy female baby without any complications. Immediate diagnosis of acute appendicitis during pregnancy is recommended and management with the suitable surgical intervention should not be delayed for >24 h as it increases the risk of perforation with its subsequent critical complications. The treatment of acute appendicitis is always surgical, with an appendectomy and perioperative broad-spectrum antibiotics. Except in cases of high maternal and fetal mortality, a CS should not be done simultaneously with the appendectomy in cases of a perforated appendix with diffuse peritonitis, due to the very high risk of dehiscence of the uterus. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Survival of Advanced Stage High-Grade Serous Ovarian Cancer Patients in the Republic of Macedonia(ID Design 2012/Scienfitic Foundation SPIROSKI, 2017-12-15); ; ; ; The primary objective of the study was to evaluate the overall survival of women with advanced stage (Stage IIIA-IV) high-grade serous ovarian cancer in Macedonia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, “Bladder Effect” - An Urodynamic Parameter to Distinguish Subtypes of Urinary Incontinence in Women(2018-04-14); ; ; Aleksandar SikoleAbstract BACKGROUND: Urinary incontinence (UI) is defined by the International Continence Society (ICS) as the involuntary loss of urine that represents a hygienic or social problem to the individual. The aetiology is multifactorial. The diagnosis of UI is important because it can result in the application of appropriate therapy. Urodynamics is a golden standard, without which every UI diagnosis is insufficient. AIM: The goal of this study was, based on urodynamic results, to prove the existence of evident differences between the subtypes of UI. METHODS: Eighty patients with UI were evaluated (50 with urinary stress incontinence-USI and 30 with detrusor instability-DI) according to a standard evaluation protocol. Exclusion criteria were: mixed UI and diseases that simulated UI. All patients were 36-65 years of age (mean 56). The following parameters were measured: maximal and average flow, maximal and average voiding pressure. These parameters were compared between both groups, to determine the diagnostic significance of the parameter “Bladder Effect” (BE). It is a product of the urine flow and the pressure during voiding. RESULTS: The results showed a significant difference with a high confidence interval. Mean BEmax was 577 units in the patient group with USI, and 1014 in the DI group. Similarly, BEav was 313 units in the USI group, and 499 units in the DI group, with a significant difference and a high interval of confidence. CONCLUSION: In conclusion, the results of the study suggested that BE could be a useful diagnostic parameter to distinguish between USI and DI. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Preoperative detection of sentinel lymph node in patients with endometrial cancer - comparison of planar lymphoscintigraphy, spect and SPECT/CT(2022); ; ; Sentinel lymph node (SLN) mapping allows minimal invasive assessment of lymph node status in patients with early-stage endometrial cancer (EC). Intraoperative detection of SLNs is based on the results obtained from preoperative nuclear medical images. The purpose of this study was to compare the data obtained from planar lymphoscintigraphy (PL), single-photon emission computed tomography (SPECT), and SPECT with computed tomography (SPECT/CT) for preoperative SLN detection in patients with EC.