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    POSTOPERATIVE SERUM CREATININ LEVEL IN TWO DIFERENT HYDRATION REGIMES IN LIVING DONOR KYDNEY TRANSPLANATATION
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, 2017-04)
    Mojsova Mijovska, Maja
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    Introduction: Early graft function is very important and can be achieved with adequate intraopeartive perfusion characteristics of the graft and urine output. The goal of this study was to examine the influence of targeting central venous pressure (CVP) on early graft function. Material and methods: After approval of Ethical committee of the Medical Faculty-Skopje, we obtained inform consent of 60 patients, ASA 2-3 undergoing renal transplantation of livingrelated person in the Clinic of Urology – Skopje. A prospective clinical study was performed in the period of 2 years. Patients were divided into 2 groups of thirty patients : group A receiving normal saline intraoperatively targeting for CVP to 15 mmHg until vascular clamps were off and group B receiving normal saline 10ml/kg/h. We recorded lactate at the end of the surgery, onset of diuresis and total urine output from unclamping the renal vessels to the end of the surgery in both groups and postoperative serum creatinine in 3times (3, 12, 36 hours). Results: The onset of diuresis in seconds was insignificantly longer in group B p>0,05 (p=o,31). The average value of postoperative levels of the lactate showed that in group B the levels of the lactate were significantly higher for Z=-5,79 and p<0,001 (p=0,000). We didn’t find any statistical differences in postoperative serum creatinine in both groups. Conclusion: Our study didn’t show any benefit from targeting CVP to 15 mmHg. We couldn’t find any significant difference on onset of diuresis and urine output after the unclamping the vessels. However, in the constant infusion group (group B) the level of the lactate was higher CVP. In postoperative biochemical parameters we had no statistical difference between the average values of serum cratinine.
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    Hypoxia during one lung ventilation in thoracic surgery
    (Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2011)
    Taleska, Gordana
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    Trajkovska, Trajanka
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    Mojsova Mijovska, Maja
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    Early resuscitation - what is changed in the treatment of Traumatic Brain Injury (TBI)
    (MedCrave Group Kft., 2020-03-09)
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    Demjanski, Vasko
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    Kishman, Aleksandar
    Background: The classical therapeutic approaches to thetraumatic brain injury (TBI) are based on astandardized care and prevention of secondary brain injuries and insults.Brain is the most sensitive tissue to hypoxemia what consequently burdens maintenance of adequate circulation. The development of hypoxia hypoxemia during traumatic brain injury (TBI) with severe shock and anaemia is the main cause for the development of secondary brain injury, which is responsible for the high fatality of the TBI. Objectives and method: The aim of this review is to discuss the available literature and guidelines for this field and to find out the possible benefits of early resuscitation. Results: Initial resuscitation starts with infusions of isotonic crystalloid solutions (e.g. sodium chloride). The main goal of the treatment is to achieve normal blood pressure and adequate oxygen supply to the tissue. Aggressive resuscitation with excessive fluid load in TBI patients may aggravate the brain oedema. The data, about early use of blood and its products in TBI patients with severe haemorrhage are poor with controversial opinions. Conclusion: The resent published guidelines do not support any specific fluid or specific transfusion practices in this setting.
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    Pediatric Enigma in ICU – Late Treatment of Severe Sepsis: A Case Report
    (ID Design 2012/DOOEL Skopje, 2012-07-31)
    Gordana Taleska
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    Zorka Nikolova
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    Maja Mojsova-Mijovska
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    Risto Simeonov
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    Trajanka Trajkovska
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    Effect of Adding Dexamethasone as a Ropivacaine Adjuvant in Ultrasound-Guided Transversus Abdominis Plane Block for Inguinal Hernia Repair
    (Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2015)
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    Zdravkovska, Milka
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    Background: The transverses abdominals plane block (TAP) is a regional anesthesia technique that provided analgesia to the parietal peritoneum, skin and muscles of the anterior abdominal wall. The aim of this randomized double-blind study was to evaluate postoperative analgesia on patients undergoing open inguinal hernia repair under general anesthesia (GA), (GA + TAP) block preformed with ropivacaine and (GA + TAP-D) block preformed with ropivacaine and 4 mg dexamethasone. Methods: 90 (ASA I-II) adult patients for unilateral open inguinal hernia repair were included in this study. In group I (n = 30) patents received only general anesthesia (GA). Patients in group II (n = 30) received GA and unilateral TAP block with 25 ml of 0.5% ropivacaine and the patients in group III (n = 30) received GA and unilateral TAP-D block with 25 ml of 0.5% ropivacaine + 4 mg Dexamethadsone. In this study we assessed the pain score - VAS at rest at 2, 4, 6, 12 and 24 hours after the operation and the total analgesic consumption of morphine over 24 hours. Results: There were statistically significant differences in the VAS scores between group I, group II and group III at all postoperative time points - 2(hr), 4(hr), 6(hr), 12(hr) and 24(hr). (p < 0.00001). The cumulative 24 hours morphine consumption after the operation was significantly lower in group III (5.53 1.21 mg) than in group II (6.16 2.41 mg) and group I (9.26 2.41 mg). This difference is statistically significant (p < 0.00001). Conclusion: Concerning the inguinal hernia repair we found better postoperative pain scores and 24 hours reduction of the morphine consumption in group III (GA and TAP-D block) compared with group I (GA) and group II (GA + TAP block).
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    Outcome in neurotrauma patients according to predictive survival scores
    (League Against Epilepsy of the Republic of Macedonia/Лига против епилепсија на Република Македонија, 2012)
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    Role of the radiological variables, clinical picture and values of C-reactive protein (CRP) and leukocytes in the brain edema development and eary intrahospital mortality in patients with hemorrhagic cerebrovascular insult
    (Macedonian Association of Physiologists and Antropologists, 2020)
    Mihajlovska Rendevska, A
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    Aleksovski, B
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    Aleksovski, V
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    Stojanov, D
    Introduction: The development of brain edema is one of the key factors that cause early neurological deterioration in patients with hemorrhagic cerebrovascular insult (H-CVI). In this study we analyzed the impact of: radiological variables (initial volume and volume of the 5th day of the intracerebral hematoma (IH), clinical state at admission (scored on appropriate scale), as well as nonspecific inflammatory markers (leukocyte count and C-reactive protein - CRP). on the development of brain edema and early in-hospital mortality, in patients with H-CVI. Material and methods: 26 conservatively treated patients with acute spontaneous intracerebral haemorrhage treated at the University Clinics of Neurosurgery and Neurology in Skopje. Computed tomography (CT) was used to evaluate radiological variables, the Canadian Stroke Scale (CSS) for neurological status scoring, as well as biochemical analysis of blood taken in the first 24 hours, to measure leukocyte counts and CRP level. Results: 8 of 26 patients (30.8%) were with lethal outcome. Initial volume of IH had the strongest effect on the development of perifocal edema, with less impact but statistically significant were: clinical status on admission and age of the patients. The strongest effect on early in-hospital mortality had all radiological variables (hematoma volume at admission and after 5 days, as well as volume of perifocal edema measured after 5 days).
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    Clinical outcome of patients with neuromuscular disease and acute respiratory failure treated with mechanical ventilation - four years experience
    (League Against Epilepsy of the Republic of Macedonia/Лига против епилепсија на Република Македонија, 2013)
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    Kuzmanovski Igor
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    Spirovska Tatjana
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    LUNG ULTRASOUND DERIVED INSIGHTS IN VENTILATOR ASSOCIATED PNEUMONIA
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2024)
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    Toleska, Marija
    Lung Ultrasound (LUS) is widely used in diagnosis and monitoring of Ventilator Associated Pneumonia (VAP). The aim of our study is to evaluate and detect local lung events in mechanically ventilated patients, as well as to evaluate the usage of LUS in distinguishing VAP from Ventilator associated tracheobronchitis. We examined LUS finings in all patients who fulfilled the criteria for VAP, and stratified them according to the CLUE Protocol. We have examined the findings for VPLUS Score of each patient and tried to find a correlation between LUS Score and VPLUS Score. The average value of total LUSS of all patients examined was 11.05. LUS Score of the upper segments versus lower segments was 0.07 versus 2.1 respectively with 95% CI from 1.44 to 2.61, and significance level p<0.0001 suggesting the existence of statistically significant difference into distribution of pathological findings in between upper versus lower lung segments. Also, we found a LUS Scores difference of 3.46 with 95%CI of 0.95 to 5.96 and significance level of p=0.0099 which implies existence of statistically significant higher LUS Score values in patients with VPLUS >2 versus patients with VPLUS of 2. In conclusion, the pathological findings in patients with VAP were distributed in the dependent regions, while upper segments were spared. Also, only patients with VPLUS>2 instead of VPLUS≥2 should be considered as having VAP.