Cvetanoski, Milche
Preferred name
Cvetanoski, Milche
Official Name
Cvetanoski, Milche
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Item type:Publication, CLL-132: Mutational Status of IGVH in Correlation with Genetic Abnormalities of Patients with Chronic Lymphocytic Leukemia in Macedonia - A Single-Centre Experience(Elsevier BV, 2020-09); ; ; Ivanovski, Martin - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CLL-393 Outcomes of COVID-19 Infections in Patients With Hematological Malignancies in Republic of North Macedonia(Elsevier BV, 2022-10); ; Labachevska, Marija Popova - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effectiveness of Ropeginterferon Alfa-2B in High-Risk Patients with Philadelphia Chromosome Negative Myeloproliferative Neoplasms- Evaluation of Clinicohaematologic Response, and Safety Profile: Single Centre Experience(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Walter de Gruyter GmbH, 2023-12-01); ; ; Stojanovska-Jakimovska, SimonaBackground: Treatment of Philadelphia chromosome negative myeloproliferative neoplasms (Ph - MPNs) requires individualized approach depending on multiple factors. Novel pegylated Interferon (IFN) formulations have become an attractive therapeutic option in young Ph- MPN patients associated with better patient compliance. Methods: In this retrospective observational study a total of 16 high-risk Ph- MPN patients treated off-label with ropeginterferon alfa-2b given twice monthly, were included. Median follow-up was 24 months. High-risk patients were defined using the IPSET score. Response to treatment was evaluated using ELN, IWG-MET EUMNET standardized criteria and occurrence of side effects was documented. Results: 11 patients were female (68.8%) and 5 male (31.2%); average age at diagnosis was 36 years (17-51); 12 patients (75%) had ET, one (6.2%) PV and three (18.8%) hypercellular phase of PMF. JAK2V617F mutation was detected in 10 patients (62.5%), CALR in three (18.8%), and three (18.7%) were triple-negative cases. In 7 patients (43.7%), ropeginterferon alfa-2b was used in first-line, and 9 (56.3%) were previously treated with HU and/or standard IFN. Among initially ropeginterferon alfa-2b treated patients, complete haematological response was observed in 4/7 (57.1%), partial in 2/7 (28.6%) and suboptimal in one (14.3%). Complete haematological response was observed in 8/9 (88.9%) among previously treated patients. Average time to blood count normalization was 8 weeks, at a dose ranging between 100mcg and 300mcg. Side effects were observed in one patient (6.2%). Conclusion: Our experience is in support of previous studies regarding ropeginterferon alfa-2b efficacy and safety profile in the treatment of young patients with Ph- MPNs. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, AUTOIMMUNE HEMOLITYC ANEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: SINGLE CENTER EXPERIENCE(Macedonian Association of Anatomists, 2024); ; ; ; Popova-Labacevska, Marija - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Allogeneic Stem Cell Transplantation in the Treatment for Transfusion-Dependent Thalassemia: Centre Experience(Scientific Foundation Spiroski (publications), 2024-11-30); ; ; BACKGROUND: Allogeneic stem cell transplantation (allo SCT) is still the only curative option for transfusion depended on β-thalassemia major (TDT). In patients with good risk features it is reasonable to anticipate a greater than 90% chance of a successful transplant outcome. With better risk stratification and supportive care, the results of allo-SCT have been improved even in high risk patients who have significant iron overload related organ dysfunction. Choosing the optimal conditioning regimen before allo SCT, stem cell source and focusing on transfusion free survival, as well as graft versus host disease (GVHD) free survival is a challenge in providing the quality of life in the post-transplant period for this indication. The aim of this article is to present first experience in the treatment of TDT with allo SCT from matched related donor (MRD). CASE PRESENTATION: We present a case of male patient diagnosed as thalassemia major (TM) at the age of 15 years referred at University Clinic for pediatric disease in Skopje, Republic of North Macedonia for treatment with allogeneic stem cell transplantation (allo SCT) from matched related family donor (MRD). Patients experienced two allo SCT due to early graft rejection after the first transplantation. The conditioning was done with MAC regimens, busulfan based for the first transplant and treosulfan based for the second transplant. CONCLUSION: Disease severity and the age of the patient has a crucial impact on transplant related mortality (TRM), event free survival (EFS) and the incidence of veno-oclusive liver disease as one of the main complications during SCT. More data is required on the etiology of frequent graft rejection in TDT studying the aspects of the graft and subsequent immune reconstitution that can improve the outcome of allo HSCT for thalassemia major. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, OBINUTUZUMAB FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: SINGLE CENTER EXPERIENCE(Faculty of Medicine, UKIM, Skopje, 2023); ; ; ; Popova Labacevska, MarijaMonoclonal antibodies (mAbs) targeting CD20 molecule on B lymphocyte are of great importance in the treatment of B-cell malignancies. In recent years a great effort has been put in developing novel mAbs that can provide greater efficacy than the well-known rituximab. A second class of mAbs obinutuzumab has been presented as a more powerful tool in the treatment of this group of patients. In this retrospective study 70 patients with symptomatic CLL were included. CLL patients were diagnosed and treated at the University Clinic for Hematology between January 2018 and January 2022. All patients were evaluated for traditional clinical and laboratory prognostic factors and newer prognostic factors including IGHV mutation status and CLL prognostic and predictive genetic abnormalities. Most of the patients treated with obinutuzumab had Binet B stage (56%). Mutational status of the immunoglobulin variable region heavy chain (IGHV) in most of CLLpatients treated with obinutuzumab was unmated IGHV gene. The most frequently encountered adverse events were tumor lysis syndrome and leukopenia. The analysis of the initial results of the application of obinutuzumab-based therapy allows us to conclude that this therapeutical modality is not associated with severe adverseevents that would limit the administration of therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Current treatment options and considerations for patients with relapsed/refractory diffuse large B cell lymphoma in North Macedonia(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2021-12); ; ; ; Kocoski, BozidarAutologous stem cell transplantation (ASCT) is considered standard therapeutic approach for patients with relapsed and refractory (R/R) diffuse large B cell lymphoma (DLBCL) that are transplant eligible. For transplant ineligible patients there are few therapeutic options and novel targeted therapies and immunotherapy that are still in development. Treatment of such patients with poor prognosis is considered to be a challenge and there is constant need for new salvage treatment regimens. The aim of this study was to evaluate patients’ characteristics and treatment strategies and considerations for diffuse large B cell lymphoma in our department, and to promote new therapeutic possibilities for R/R patients with NHL DLBCL. A total of 308 patients with NHL were treated at University Clinic for hematology from 2008 until 2020 and 49% (151) of patients with NHL DLBCL were included in this study. Survival analysis of all analyzed relapsed/refractory NHL patients revealed statistically significant better survival in patients with low risk IPI score, disease stage I/II and patients with age <60 years. R CHOP was superior treatment as first line regimen and in the R/R patients, ASCT was statistically superior to other available second line treatment options. Overall survival in patients with DLBCL that achieved complete response after initial treatment was 80%. The incidence of disease relapse after initial treatment in the first 12 months was 18%. Overall survival in all treatment groups was 60% in the evaluated period of 2.5 years follow up. A total of 60% of patients with relapsed forms of NHL DLBCL were candidates for treatment with high-dose chemotherapy and ASCT. Other 40% patients were not candidates for ASCT. In conclusion we confirm the need for new treatment options for patients that relapse after ASCT and that are transplant ineligible. Patients and disease characteristics can be used to identify high-risk patients, classify once relapsed patients and define decision on further treatment - Some of the metrics are blocked by yourconsent settings
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