Donev, LJupcho

Preferred name

Donev, LJupcho

Official Name

Donev, LJupcho

Translated Name

Донев Љупчо

Alternative Name

Donev, LJupcho

Донев Љупчо

Донев Љ

Donev Lj

Ljupcho Donev

Ljupco Donev

Donev Ljupco

Donev. Ljupcho

Ljupcho.Donev

Now showing 1 - 10 of 15

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Spontaneous rectus sheath hematoma– cause of acute abdomen in patients on anticoagulant therapy: two case reports
(Scientific Foundation SPIROSKI, 2020-07-16)
Petreski, Dimitar
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Todorovic, Lazar
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Kamiloski, Marjan
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(Spontaneus) Rectus sheath hematoma ((S)RSH) is an accumulation of blood in the sheath of the rectus abdominis muscle, secondary to rupture of an epigastric vessel or muscle tear. It is defined as spontaneous in patients without history of abdominal trauma. It can be located supra- or infraumbilically. Although the exact incidence is unknown, Klingler et al. observed 23 cases (1.8%) of rectus sheath hematoma among 1257 patients evaluated by ultrasound for acute abdominal disorders. Ultrasonography can help in the diagnosis, but CT scan is most accurate in its ability to define the lesion. When diagnosed clinically, a conservative therapeutic program can usually be instituted. Only in cases of supportive management failure, progressive and large hematoma or uncontrollable hemodynamic patients, interventional management including surgery or less invasive newer techniques is indicated. Case presentation: We present two cases of SRSH in patients using oral anticoagulant agent (acenocoumarol). Their chief complaint was sudden onset of acute abdominal pain. On admission they were haemodynamically stable. After thorough clinical evaluation a suspicion for SRSH diagnosis was made and then confirmed by ultrasonography and CT. Both of them were successfully treated conservatively and discharged home in a good general condition. Conclusion: These two cases illustrate the accurate diagnosis of SRSH treated conservatively leading to optimal patient outcomes.
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IATROGENIC HYPERNATREMIA AFTER HYPERTONIC SALINE IRRIGATION OF SPLENIC HYDATID CYST –
(Department of Anaesthesia and Reanimation Faculty of Medicine, “Ss. Cyril and Methodius” University, Skopje, R.N.Macedonia, 2020-10)
Michunivikj Derebanova Lj
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Leshi A
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Jovchevski L
Pediatric hypernatremia is a rare electrolyte abnormality. However, it can be a complication of hypertonic saline irrigation in hydatid disease. In our case report, we present a ten-year-old boy with splenic hydatid cyst who received operation treatment and developed electrolyte disturbances. Our aim is to emphasize the potential dangers of the use of hypertonic saline and the appropriate management of hypernatremia.
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EPINEPHRINE AND DEXAMETHASONE AS ADJUVANS IN SUPRACLAVICULAR BLOCK IN PEDIATRIC PATIENTS: A CASE SERIES
(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2021-06)
Mikjunovikj Derebanova Lj
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Leshi A
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Toleska M
Supraclavicular brachial plexus blocks are not common in pediatric patients due to the risk of pneumothorax, but they are considered to be one of the most effective anesthetic procedures for upper extremity surgeries. Ultrasound-guided approaches increase efficacy of blocks and may reduce the risk of complications associated with injection of large volumes of local anesthetic. Adjuvants are often used with local anesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anesthetics. This paper reports three cases of pediatric patients who received ultrasound-guided supraclavicular brachial plexus block for upper limb surgery while applying different adjuvants (epinephrine and dexamethasone).
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Approach to one lung ventilation during surgical removal of aspirated light bulb in a child
(Department of Anesthesia and reanimation, Faculty of Medicine, Ss. Cyril and Methodius University Skopje, 2018-12)
Gjorchevska E
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Dimitrova M
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Simeonov R
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Comparison of benzodiazepines and opoides as oral premedication in pediatric anesthesia
(Македонско лекарско друштво = Macedonian Medical Association, 2017)
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Albert Leshi
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Two case reports on the effects of sevoflurane exposure duration on serum levels of neuron specific enolase (NSE) and S100 protein in children
(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-03)
Demjanski, Vasko
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Mikjunovikj Derebanova, Ljubica
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The length of sevoflurane exposure may raise the risk of neuron-specific enolase (NSE) and S100 protein alterations in blood, which might thereafter result in postoperative cognitive dysfunction (POCD). The pathophysiology of POCD caused by the volatile anesthetic sevoflurane has been the subject of extensive research in recent years. This case study looks at preliminary findings about the effects of different sevoflurane anesthetic exposure durations on the levels of S100 protein and NSE in children’s blood. Additionally, it looks into how sevoflurane affects children’s early cognitive performance following surgery. To detect neurological effects during general anesthesia and ascertain the length of sevoflurane exposure, we employ the particular markers such as S100 protein and NSE. In this case study, we present two pediatric patients who underwent general anesthesia with sevoflurane for different durations. The aim was to observe potential postoperative changes in NSE and S100 protein levels, which are biomarkers associated with neuronal injury and cognitive function. After the surgery, we utilize these levels to assess any cognitive problems. The parents or guardians gave their informed consent.
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DELAYED COMPLICATIONS FOLLOWING LONG-TERM CENTRAL VENOUS CATHETER PLACEMENT IN PEDIATRIC ONCOLOGY CASES
(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2024)
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Litajkovska, Slavica
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Aleksovski, Zlatko
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Introduction: Modern chemotherapy protocols in pediatric oncology necessitate the deployment of central venous catheters. The duration of catheter usage ranges from several months to a year. Typically, long-term central venous catheters (LCVC), including external tunneling (ETLCVC) and totally implanted (TILCVC) variations, are employed for this purpose. Aim: This study aims to assess the superiority of ETLCVC over TILCVC and to evaluate the occurrence of delayed complications, specifically focusing on catheter occlusion, dislocation of the catheter and catheter – related thrombosis, following the placement of central venous catheters. Material and Methods: This prospective interventional clinical study encompassed 120 pediatric patients, aged 2-14 years, diagnosed with leukemia, lymphomas and solid tumors. The participants were stratified into two groups (n=60). Group 1 received ETLCVC, whereas Group 2 underwent TILCVC placement. An informative interview was conducted with the eligible patients' parents, and written consent for study participation was obtained. Results: In the group of patients with an implanted ETLCVC, four patients had a dislocation of the catheter, three patients had a catheter occlusion, two patients had a catheter – related thrombosis. In the group of patients in whom a TILCVC was implanted, one patient had an dislocation of the catheter, one patient had catheter occlusion, and there wasn’t any patient with catheter – related thrombosis. Conclusion: Incidence of delayed complications (catheter occlusion, dislocation of the catheter, and catheter –related thrombosis) in our study were more frequent in patients in whom ETLCVC was applied, but this difference did not have statistical significance.
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BEDSIDE ECHOCARDIOGRAPHY IN A HEMODYNAMICALLY UNSTABLE CHILD
(Department of Anesthesia and reanimation, Faculty of Medicine, "Ss.Cyril and Methodius", University Skopje Macedonia, 2019-12)
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Toleska M.
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Trposka A.
Introduction:Echocardiography may be considered as an important tool due to hemodynamic assessment of a hemodynamically unstable child in a Pediatric Intensive Care Units (PICU), which could provide identification of the etiology and pathophysiology of hemodynamic instability but also to help due to guiding therapy. Objectives: The aim of our cohort study is to determine the impact of usage of fast focused echocardiography examination in the Surgical PICU done by Anesthesiologist/Intensivist. Material and Methods: We’ve made a fast focused bedside transthoracic echocardiographic examination of 11 hemodynamically unstable children using the regular parasternal long and short axis view and four chamber subcostal view of the heart, LVOT, aorta, truncus pulmonalis and Inferior vena cava (IVC) for qualitative assessment. Dimensions and collapsibility of IVC were measured. The youngest patient was premature neonate born in 28th gestation week and the oldest was 12 years old child. Results: In 9 out of 11 children we’ve identified abnormality by the qualitative assessment of the heart due to performing focused echocardiography. In 4 children we found global myocardial hypokinesia, one child with insignificant pericardial effusion (2 mm) and 4 children with Inferior vena cava collapsibility greater than 50%. In the children with hypokinesia inotropic support was established while the children with IVC collapsibility greater than 50% were treated with fluid boluses. Persistence of foramen ovale as a random finding was seen in 5 neonates, insignificant for the hemodynamic instability. Conclusion: Several studies have shown the positive effect of the echocardiography usage in the management of critically ill children, changing their treatment in 30%–60% of cases after the test is performed (2). From our study we can conclude that performing focused echocardiography is feasible and provides valuable data which could lead to improved care of severely ill children and thus should be encouraged in daily ICU practice.
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EIGHT YEARS OF HEMODIALYSIS WITH TUNNELED DIALYSIS CATHETER PLACED IN RIGHT VENTRICLE: A CASE REPORT
(“Ss. Cyril and Methodius” University, Skopje, R.N. Macedonia, Faculty of Medicine, Department of Anaesthesia and Reanimation, 2018-05)
Mikjunovikj Lj
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Safe pediatric one-lung ventilation in a resource-limited setting: an age- and weight-guided approach
(Springer Science and Business Media LLC, 2025-12-10)
Sulejmani, Haris
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Golubic, Sanja
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Background One-lung ventilation (OLV) in children is technically demanding due to small airway calibers, variable bronchial anatomy, and limited pediatric-specific devices. Challenges are greater in resource-limited settings where double-lumen tubes (DLTs) and fiberoptic bronchoscopes are not consistently available. Methods We retrospectively reviewed five consecutive pediatric patients (ages 4–13 years) who underwent thoracic surgery with OLV between 2022 and 2024. Case summaries highlighted device choice, confirmation method, and perioperative challenges. Variables included demographics, diagnosis, surgical side, isolation technique, OLV duration, ventilatory parameters, arterial blood gases, and defined outcomes (desaturation, hypercarbia, hemodynamic instability, device dislodgement, and postoperative complications). Results Lung isolation was achieved with DLTs in two older patients and bronchial blockers in three younger ones, guided by age and weight. OLV lasted 105–150 min. Two children developed transient desaturation (nadir SpO₂ 75%), one experienced hypercarbia (PaCO₂ >50 mmHg), and two had hemodynamic instability. No tube dislodgement occurred. Median ICU stay was 17 h (IQR 8–19), and hospital stay 21 days (IQR 15–21). All patients were discharged in stable condition. Conclusion An age- and weight-based algorithm bronchial blockers for children < 8 years or < 30 kg, DLTs for older/heavier patients enabled safe OLV and preserved oxygenation, even without routine fiberoptic bronchoscopy. Vigilant ETCO₂ monitoring, careful device fixation, and close intraoperative assessment compensated for equipment limitations. This pragmatic workflow demonstrates feasibility in resource-constrained environments, provides practical guidance for clinicians, and is hypothesis-generating for future multicenter studies.

Donev, LJupcho

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