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    Percutaneous Nephrostomy as a Procedure in the Treatment of Urinary Tract Obstruction - Experiences in the University Clinic of Urology in Skopje
    (Macedonian Academy of Sciences and Arts, 2024-04)
    Trifunovski, Aleksandar
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    Atanasova, Ana
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    Obstructive uropathy encompasses various urinary tract obstructions, leading to changes in urine flow, kidney pressure, and impaired kidney function. Predicting renal recovery from obstructive uropathy, can be challenging and necessitates treatment, as in percutaneous nephrostomy (PNS) drainage. The choice of drainage method depends on patient-specific factors and local expertise. According to the data for the Republic of North Macedonia, in the register of the European Renal Association, in the last few years, there has been an increase in the percentage of patients with obstructive nephropathy from 7.6% to 8.9% who end up on a chronic hemodialysis program. Prompt relief from urinary tract obstruction is essential to preserve renal function and prevent complications. The aim of this study is to present our initial data analysis of recent experience in the use of nephrostomies as a method for temporary or long-term resolution of obstructive nephropathy, in terms of safety and success in preserving kidney function and reducing the number of patients on hemodialysis.
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    ENIUS. European Network of multidisciplinary research to Improve the Urinary Stents. COSTS Actions. CA16217. European Cooperation in Science & Technology
    (Springer Science and Business Media LLC, 2020-10-28)
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    The purpose of this study is to determine the effects of intubation, the impact of complications and to estimate the necessity of improving urinary stents used during pregnancy. Hydronephrosis during pregnancy most commonly develops as a result of compression of the ureters as well as the effect of progesterone on the smooth muscle relaxation. Clinical significance of hydronephrosis lies in the association between ureteral obstruction and the high frequency of ascending urinary tract infection during pregnancy. Most of the cases of symptomatic hydronephrosis in pregnancy resolve with conservative measures with a rare need of stent insertion. When needed, ureteric stents are inserted with local anaesthesia under transabdominal US guidance. Pain and discomfort are common experiences during the procedure. The most common complication of ureteric stents is encrustation which occurs in this population likely secondary to the changes in urinary chemistry during pregnancy, such as hypercalciuria and hyperuricosuria. Ureteric stents placed in pregnant women are generally exchanged every 4–6 weeks in order to avoid encrustation and potential obstruction, necessitating the repeated cost and morbidity of repeated procedures. Infection and migration are other complications of internal stent replacement. In addition, this repetitive procedure can induce rupture of the intrauterine membranes in some cases, or can induce preterm delivery due to invasive and uncomfortable procedure especially in the third trimester of pregnancy. Sometimes for removal of the ureteric stent performing ESWL is inevitable because severe incrustation prevents stent removal after delivery, especially for patients without periodical replacement of the stents. Multiple procedures, morbidities, antibiotics, dietary calcium restriction and pain associated with ureteral stents replacement can all have a negative impact on a pregnancy. For these reasons, biodegradable stents should be preferred and are ideal solution in the properly selected pregnant patient, particularly as this device technology continues to improve.
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    Ligasure hemorrhoidectomy (LH) with „near base“ technique
    (Springer Science and Business Media LLC, 2021-10)
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    Jovanovska, Frosina
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    Mustafova, Alma
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    Dervisov, Kristijan
    Ligasure hemorrhoidectomy (LH) with „near base“ technique Şenol Tahir*, Martina Ambardjieva, Frosina Jovanovska, Alma Mustafova, Kristijan Dervisov, Nimetula Limani, Berat Dalipi, Petar Markov University Clinic for Surgical Diseases, General and Abdominal departemen – St. Naum Ohridski, Skopje, N. Macedonia Background: In this study we evaluate the use of MilliganMorgan hemorrhoidectomy with Ligasure vessel sealing. Methods: Grades 3 and 4 hemorrhoids are operated with Ligasure by coagulation and cutting of the hemorrhoids at positions 5, 7 and 11 hour. Te patients received premedication, analgesia and intravenous 500 mg metronidazole preoperatively. Under anesthesia, placed in a lithotripsy position, the anoscope is placed with a easy retraction, than a 5 mm V shape incision is made with the scalpel at the anocutaneous border. Te nodule was lifted with an instrument and the LigaSure was placed on the base of the nodule (leaving 2 mm enough mucosa above the sphincter), coagulated and incised. Te control check, 24 hours later and sent home with oral analgesic and metronidazole therapy. Follow-up 7, 14 and 28th day Results: 52 patients undergoing LH surgery, with an average age of 42.5 years. 59 % are women and 56 % are grades III. Average operative intervention 17.0+4.1 minutes, hospital stay 1.2 days, Postoperative pain (VAS1-6) 3. Urinary retention 0.4 %. Minor bleeding 5.6 %. Pruritus in 5.6 %, gas incontinence 7.6 %. No stenosis or incontinence. Conclusions: LH is an efective and safe surgical method and it should be used as a routine.
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    Predictive Value of Alvarado, Acute Inflammatory Response, Tzanakis and RIPASA Scores in the Diagnosis of Acute Appendicitis
    (Vilnius University Press, 2020-12-29)
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    Markov, Petar
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    Mladenovik, Dragoslav
    <jats:p>Introduction. The diagnosis of acute appendicitis (AA), as the most common cause of acute abdominal pain, has changed in the past decade by introducing scoring systems in addition to the use of clinical, laboratory parameters, and radiological examinations. This study aimed to assess the significance of the four scoring systems (Alvarado, Appendicitis Inflammatory Response (AIR), Raya Isteri Pengiran Anak Saleha Appendicitis (RIPASA) and Tzanakis) in the prediction of delayed appendectomy. Materials and methods. The study included 100 respondents, who were diagnosed with AA in the period from January 2018 to February 2019 and were also operated on. In addition to the clinical, laboratory, and ultrasonographic examinations, four scoring systems (Alvarado, AIR, RIPASA, and Tzanakis) were used to diagnose AA. According to the obtained histopathological (HP) findings, the patients were divided into 3 groups: timely appendectomy, delayed appendectomy and unnecessary appendectomy. Using the sensitivity and specificity of all 4 scoring systems, ROC analysis was performed to predict delayed appendectomy. Results. In the study that included 100 patients (58% men, 42% women), after the appendectomy was performed, the resulting HP showed that 74% had a timely appendectomy, while 16% had delayed and 10% had an unnecessary appendectomy. For the prediction of delayed appendectomy, the area under the ROC curve showed a value of 0.577 for the Alvarado score, 0.504 for the AIR, 0.651 for the RIPASA, and 0.696 for the Tzanakis. Sensitivity and specificity for the Alvarado score was 54% and 62%, for RIPASA 62.5% and 63.5%, for Tzanakis 69% and 60.8%, respectively. Combining the three scoring systems (Alvarado, RIPASA, and Tzanakis), the surface area under the ROC curve was 0.762 (95% CI 0.521–0.783), with a sensitivity of 85% and a specificity of 62%. Conclusion. In our study, the diagnostic accuracy of RIPASA and Tzanakis showed better results than Alvarado, while AIR cannot be used to predict delayed appendectomy in our population. However, the simultaneous application of all three scoring systems, RIPASA, Tzanakis and Alvarado, has shown much better discriminatory ability, with higher sensitivity and specificity, as opposed to their use alone. Combining scoring systems should help in proper diagnosis to avoid negative appendectomy, but additional studies with a larger number of patients are needed to support these results.</jats:p>
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    Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature
    (Walter de Gruyter GmbH / Macedonian Academy of Sciences and Arts, 2021-12-30)
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    Janculev, Josif
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    Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. We present here a case report of an adrenal SFT which is compared to 11 other known cases. Our case report is from a patient with SFT on the left adrenal gland, followed by mild symptoms of abdominal discomfort and hypertension. Physical examination, laboratory, and radiological tests were performed. The patient underwent surgery and the material was sent for histopathologic analysis for a definite diagnosis. Regular follow up appointments were performed over the course of two years. No recurrence of the tumor has been detected. We explain the symptoms, diagnosis, treatment, and additionally we describe the results and implications of the findings reported in the literature. Correct diagnosis is mandatory for optimal management of solitary fibrous tumor patients.
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    LIGASURE HEMORRHOIDECTOMY (LH) WITH “NEAR BASE“ TECHNIQUE
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023)
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    Jovanovska, Frosina
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    Limani, Nimetula
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    Mustafova, Alma
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    Antenatal risk factors for infection and neonatal outcome
    (2014-05-10)
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    Kovachev, Bogdan
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    Antevska, Maja
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    Introduction: There are a number of conditions which can occur during pregnancy that bring an increased risk for the newborn of developing an infection. These include chorioamnionitis and Premature Rupture of the Membrane (PRM) which can be brought on by vaginal infections of the mother. Chorioamnionitis represents an infection of the chorion and amnion, and PRM represents rupture of the membranes more than 12 hours before the onset of labor. Material and method: Data was retrieved from the neonatal histories of the newborns bom at the University Clinic for Gynecology and Obstetrics in Skopje. During the period from 18" November 2013 until 15 "" April 2014, data from 122 newborns was collected. Inclusion criteria were: newborns from mothers with known antenatal risk of infection (chorioamnionitis, premature rupture of the membranes or positive vaginal swabs). Results: From the 122 newborns, 13.11% (16) presented with clinical manifestations of infection, with the most common being: pyodermia connatalis 56.25% (9), blepharoconjunctivitis 31.25% (5) and congenital bronchopneumonia 12.5% (2). Increased risk factors showed: Majority of newborns from mothers with positive Group Streptococcus (GBS) vaginal swabs presented with congenital bronchopneumonia, majority of newborns from mothers with PRM presented with pyodermia connatalis and majority of newborns from mothers with positive Candida albicans vaginal swabs presented with blepharoconjuctivitis Newborns from mothers with Chlamydia trachomatis and Ureaplasma urealyticym positive vaginal swabs and chorioamnionitis did not show clinical manifestations of infection within the early neonatal period. Conclusion: It is important for clinicians to diagnose antenatal risk factors for preventing neonatal infections. GBS and Candida infections and also PRM seem to be important factors that contribute to neonatal infection. Although Chlamydia and Ureaplasma infections and chorioamnionitis did not present with neonatal infection, literature data comes later so they also need to be considered. shows their manifestation
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    Palpable abdominal mass persisting for a long time: a case report
    (Balkan Association of Urology, 2022-09-30)
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    Kjamili, Jeton
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    Janchulev, Josif
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    Introduction: The urachus is the remnant of the connection between the urinary bladder and the allantois. Rarely, the urachus partially obliterates or reopens under pathological circumstances. Pathology of the urachus in adults is rare but often manifests as an acute abdomen, umbilical infection, or fistula. We present a case of inflamed urachus sinus and cyst presenting as a tumorous abdominal mass that infiltrate the nearby organs Case report: A 67-year-old patient was referred to our urology clinic with a complaint of pneumaturia and presence of an abdominal mass for one year. On clinical examination, a palpable painless mass was present suprapubically to the right. There were no skin changes. There were no previous operations, nor more serious chronic diseases. Laboratory tests, including tumor markers, were unremarkable. Computer tomography (CT) revealed air in the bladder and suspected vesicointestinal fistula. A voiding urethrocystography revealed no fistulous channel, but only air in the bladder. A colonoscopy was performed and hypertrophic valvula Bauhini was observed. A cystoscopy with transurethral resection was performed on the abnormal mucosa on the right side of the vertex and histopathological analysis (HPA) revealed chronic cystitis and urachus fragments. The patient was prescribed antibiotic therapy for one month, and there was mass reduction and clinical improvement but no complete resolution. It was decided to proceed with a laparotomy. Total tumor removal with a partial cystectomy, hemicolectomy, also a lymphadenectomy was performed. HPA revealed phlegmonous urachal sinus and urachal cyst with inflammatory changes of the urinary bladder, terminal ileum, caecum, appendix, ascending colon and right ovary. Conclusion: Adult urachal abnormalities are uncommon, yet because of their various clinical manifestations, they are frequently misdiagnosed. Planning the right surgical treatment with the assistance of an early diagnosis helps lower morbidity.
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    Giant Retroperitoneal Liposarcomas with Involving Adjacent Abdominal Organs: Two case reports
    (2022-09-15)
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    Jovanovska, Frosina
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    Mustafova, Alma
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    Bundovska, Marija
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    Panic, K