Achevski, Blagoj
Preferred name
Achevski, Blagoj
Official Name
Achevski, Blagoj
7 results
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Item type:Publication, A stability-indicating HPLC method for determination of folic acid and its related substances in tablets(Macedonian Pharmaceutical Association in cooperation with Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy., 2022) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Systematic approach for proper control chart design for Karl-Fischer titrator(Macedonian Pharmaceutical Association, 2022-12-31); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Static and dynamic quantum mechanical methods for exact interpretation of Infrared Multiple Photon Dissociation Spectra: current state and development perspectives(Macedonian Pharmaceutical Association, 2022-12-31); ; ; Pejov, Ljupco - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular Hydrogen Acts as a Hydrogen Bond Proton Acceptor: From Protonated Betaine Tagging to the Weakest Hydrogen Bond(American Chemical Society (ACS), 2024-05-09); Pejov, Ljupcho - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Understanding the Infrared Multiple Photon Dissociation Spectra of Hydrogen‐Tagged Protonated Betaine: Vibrational Confinement Counteracts the Hydrogen Bonding Induced OH Stretching Frequency Downshift(Wiley, 2025-06-11); Pejov, Ljupcho<jats:p>Finite‐temperature vibrational spectra of protonated betaine and its noncovalently bonded clusters with molecular hydrogen are modeled using Lagrangian dynamics with the atom‐centered density matrix propagation (ADMP) scheme. The focus is put on the O-H stretching mode, which serves as a primary indicator of the type and strength of the noncovalent intermolecular interactions. The computed anharmonic OH stretching vibrational frequency shifts in the case of protonated betaine upon tagging with H<jats:sub>2</jats:sub> at the OH group site at 40 K are in quantitative agreement with the experimental infrared multiple photon dissociation data. The shifts computed from simulations at 4 K contain only the harmonic contributions. It is found that this is a consequence of vibrational confinement of the O-H oscillator caused by the H<jats:sub>2</jats:sub> tagger, which remains close to the vibrating atoms throughout the simulation and counteracts the frequency redshift induced by the weak hydrogen bonding interaction. Changes in the O-H stretching potential, along with a small but observable confinement relaxation at 40 K leads to O-H stretching frequency downshift as compared to 4 K. Application of the two‐trace 2D correlation analysis of the computed vibrational density of states spectra enables a clear distinction between bands of different origin to be made.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, What happens when you heat nicotine molecule in different atmospheres – a molecular modelling perspective(5th Scientific Summit Tobacco Harm Reduction: Novel products, research and policy, 21 – 22 September 2022, Athens, Greece (Abstract book, poster presentation), 2022); ; Pejov L.The fate of nicotine molecule, when heated at different temperatures in different surroundings (i.e. atmospheres) is of fundamental importance to harm reduction when inhaling the aerosols of different tobacco products. In the present study, we tackle this issue from the viewpoint of molecular modelling. Series of ab initio molecular dynamics simulations of free nicotine molecule as well as of nicotine molecule in the presence of oxygen molecules at series of different temperatures ranging from 600 to 1200 K are performed with the atom-centered density matrix propagation scheme (ADMP). Simulations are performed at different levels of theory. The possible degradation pathways implied by the generated molecular dynamics trajectories are related to the products detected in the smoke of conventional cigarettes and aerosols generated by electronic devices for controlled heating of tobacco. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of intellectual property rights and package safety features in the prevention of counterfeit medicines(Centre for Evaluation in Education and Science (CEON/CEES), 2020-12); ; ; Petrovska-Jakimovska, BiljanaThe fast growth of counterfeiting medicines in the last two decades has created one of the biggest problems facing the pharmaceutical industry on the global level, resulting in loss of income, product withdrawal, loss of brand value, etc. But this is not only the problem of the intellectual property rights of the pharmaceutical industry, it is also the problem of the healthcare regulatory authorities, whose most significant concern is the risk to the public health. Pharmaceutical manufacturers, together with the wholesalers and retailers, have an essential role in the fight against counterfeit medicines by the implementation of different anti-counterfeit technologies for securing the supply-chain of medicines. The protection of drug packaging has a specific role in the drug development process, as well as in the fight against counterfeit medicine. The authenticity of the medicine and the forensic elements for protection on the packaging may be confirmed using different technologies. Tracking and tracing of pharmaceutical products in the supply chain, keeping electronic records for all stages of the distribution, and verification of the authenticity of a medicinal product is a key element and an effective solution for timely detection of counterfeit medicines and protection of intellectual property rights.