Mladenovska Stojkoska, Ivana
Preferred name
Mladenovska Stojkoska, Ivana
Official Name
Mladenovska Stojkoska, Ivana
Main Affiliation
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Item type:Publication, Assessment of Prevalence and Risk Factors for Diabetic Retinopathy in Patients with Type 1 and Type 2 Diabetes Examined at a Tertiary Care(Walter de Gruyter GmbH, 2023-07-01); ; ; Guceva Laban, Nevenka<jats:title>Abstract</jats:title> <jats:p> <jats:bold>Introduction</jats:bold>: Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus and the leading cause of visual impairment and blindness. The aim of the study was to estimate and compare the prevalence of DR and to determine an association between DR and systemic risk factors in hospitalized type 1 (DMT1) and type 2 (DMT2) diabetic patients.</jats:p> <jats:p> <jats:bold>Material and methods</jats:bold>: We analyzed 260 patients with diabetes, 43 with DMT1 and 217 with DMT2. The following data were collected: age, gender, type and duration of diabetes, glycemic control, blood pressure, estimated glomerular filtration rate, ophthalmologic examinations and routine biochemical parameters.</jats:p> <jats:p> <jats:bold>Results</jats:bold>: Out of the total number of 260 patients, 77 (29.6%) had non-proliferative DR (NPDR), 21 (8.1%) had proliferative DR (PDR), 29 (11.1%) had diabetic macular edema (DME), and 69 (23.5%) had diabetic cataracts. Forty-three (16.5%) patients were previously diagnosed with DMT1 and 217 (83.5%) with DMT2. The duration of diabetes was not significantly longer in DMT1 (12.8±11.2 years) in comparison to DMT2 (11.07±8.1 years). The prevalence of NPDR and PDR did not differ statistically in either groups. DME was more prevalent in DMT2 than in DMT1 (P<0.05). Diabetic cataract was found in 26.7% vs. 6.7% of patients with DMT2 and DMT1, respectively (p<0.01). The duration of diabetes significantly correlated with NPDR and PDR in DMT1 (r=o.31, p<0.05; r=0.55, p<0.001, respectively). In DMT2, significant correlations were found between the duration of diabetes and cataract, NPDR, PDR and DME (r=0.31, p<0.001; r=0.43 p<0.01, r=0.16 p<0.05 and r=0.20 p<0.01, respectively). Fasting plasma glucose (FPG) significantly correlated with PDR (r=0.258, p<0.05), while HbA1c with DME (r= 0.15 p<0.05).</jats:p> <jats:p> <jats:bold>Conclusion</jats:bold>: The duration of diabetes and hyperglycemia were associated with DR in both types of diabetes.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Corrélation entre les scores de risques d’ulcération du pied chez les diabétiques et la maladie rénale chronique(John Libbey Eurotext, 2017-09); ; ; Introduction Le pied diabétique est une lésion dans le pied ou membres inférieurs, qui est causée par une angiopathie diabétique et de l’infection neurologique. C’est une des complications les plus graves du diabète. Patients et méthodes Le but d’étude se d’évaluer la corrélation entre les scores de risque d’ulcération du pied chez les malades atteints de diabète de type 2 et le degré de maladie rénale chronique (MRC). De comparer ces risques et leur impact sur les facteurs métaboliques ainsi que les facteurs qui influencent le temps d’identification de risque d’ulcération du pied et le degré de MRC. Résultats Il s’agit d’une étude transversale, dans lequel, pendant la visite 1 (V1), le nombre total de patients atteints de DM2 et MRC ont été examinés ainsi que 6 mois plus tard durant la visite 3 (V3). Les malades ont été examinés et testés pour le pied diabétique et classifié selon le groupe de travail international (IWGDF) dans trois groups : risque moyenne, haut risque et très haut risque. De plus les malades ont été examinés et classifiés pour le degré de MRC selon la formule de Cockroft–Gault et MDRD. Le nombre total des malades qui ont entré dans l’étude est 107, et parmi 50,5 % étaient des hommes et 49,5 % étaient des femmes. L’âge moyen des malades était 59,12 ans, et moyen niveau d’HbA1c était 9,5 % et six mois plus tard le niveau d’HbA1c était 8,8 % (p < 0,004). L’IMC était 28 kg/m2. Le score de risque à V1 et V3 a une signification statistique (p < 0,004) à savoir V3 montre score plus élevé de risque. L’analyse de corrélation montre que les groupes ayant un risque plus élevé de points d’ulcération (2 et 3) ont également un degré de néphropathies supérieur (3 et 4) pendant V1 et aussi pendant V3 (p < 0,001). Discussion Chez les malades d’âge moyen atteints de DM2 et MRC, la durée de DM2, HbA1c et la pression artérielle élevée ont un rôle important dans l’évaluation du risque d’ulcération du pied et la progression de la MRC. Conclusion Les patients présentant un risque élevé pour les scores d’ulcération, se rapportent à un degré de néphropathies supérieur. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Once-weekly semaglutide use in glucagon-like peptide-1 receptor agonist naïve patients with type 2 diabetes in North Macedonia: Real-world data from the MIRAGE study(Elsevier BV, 2023-11); ; ; Aims The MIRAGE study aimed to evaluate the real-world use of once weekly (OW) subcutaneous semaglutide in glucagon-like peptide-1 receptor agonist naïve type 2 diabetes patients in routine clinical practice in North Macedonia. Methods MIRAGE was a multicentre, single-arm, retrospective and 30-weeks study, conducted in North Macedonia. Primary [change in glycated haemoglobin (HbA1c)] and secondary endpoints [change in body weight, fasting plasma glucose (FPG), lipid parameters, blood pressure, waist circumference, glycaemic and weight-loss target achievement] were evaluated between baseline and end of study (EOS). Results Baseline characteristics of 314 patients enrolled in the study were, mean age: 55.5 years, HbA1c: 9.0%, diabetes duration: 7.8 years, body weight: 105.2 kg and waist circumference: 114 cm. Patients at EOS experienced statistically significant estimated mean change in HbA1c: -2.2% points, body weight: -9.0 kg, and FPG: -4.1 mmol/L (all p<0.0001). At EOS, 62.1% patients achieved HbA1c <7%, and 79.3% had ≥1% HbA1c reduction. A weight reduction of ≥3% and ≥5% was noted in 88.3% and 73.3% patients, respectively. No new safety concern has emerged. Conclusions Findings from MIRAGE study demonstrated glycaemic and weight-loss benefits of semaglutide, with improvements in other cardiometabolic parameters. The study supports real-world OW subcutaneous semaglutide use in North Macedonia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTHROPOMETRIC INDEXES OF VISCERAL OBESITY RELATIONS TO DYSLIPIDEMIC PROFILE IN METABOLIC SYNDROME(2019); ; Zivkovic, MarijaIntroduction: Visceral obesity and dyslipidemia are the main characteristics of the metabolic syndrome. Objective: The relationship of abdominal sagittal diameter to thigh circumference ratio (SD/T) with anthropometric indexes of visceral obesity waist circumference (WC) and waist hip ratio (WHR) was determined as well as their association with lipid levels. Material and methods: Triglyceride (TG), cholesterol (C), HDL and LDL levels, LDL/HDL, C/HDL as well as WC, WHR and SD/T were determined in 250 healthy women divided into 3 groups according to body fat distribution by their WHR values: 1stgr WHR<0.85; 2ndgr WHR (0.85-1.0) and 3rdgr WHR>1.0. Results: SD/T correlated significantly positively with TG and C (p<0.0001), LDL (p<0.006), LDL/HDL and C/HDL (p<0.0001), also with WC and WHR (p<0.0001), and negatively with HDL (p<0.001). WC and SD/T levels were significantly higher in the 3rd gr (125.16±15.26cm; 0.49±0.38) compared to the 2nd gr (109±14cm; 0.39±0.43) and the 1stgr (88±17cm; 0.32±0.37)(p<0.0001). TG levels in the 3rd gr (1.87±0.69ng/ml) were significantly higher compared to the 1st gr (1.03±0.42ng/ml) and the 2ndgr (1.69±0.92ng/ml) (p<0.0001). HDL in the 3 rd gr was (0.95±0.23ng/ml), significantly lower compared to the 1stgr. (1.24±0.27ng/ml) (p<0.001) and 2n dgr (1.07±0.39ng/ml) (p<0.028). LDL, C/HDL, LDL/HDL and C levels were also significantly higher in the 3rdgr. Conclusion: Visceral obesity was characterized with increased values of WHR, WC and SD/T, which were positively related to dyslipidemic profile. Positive relation of SD/T with atherogenic lipids, atherogenic indexes, WHR and WC, and negative relation with HDL, confirmed it as an important anthropometric diagnostic parameter of visceral obesity in metabolic syndrome. - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Successful pregnancy outcome in patient with congenital adrenal hyperplasia(Macedonian Association of Anatomists, 2018-12-27); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A CASE OF IDIOPATHIC OSTEOPOROSIS IN 43 YEARS OLD MALE PATIENT(Scientific association of endocrinologists and diabetologists of Macedonia, 2022-10); - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, THYROIDITIS SUBACUTA FROM EPSTEIN BARR VIRUS- CASE REPORT(2022-10); ; Introduction: Subacute thyroiditis (SAT) is a self-limiting inflammation of the thyroid gland that is associated with a three-phase clinical course of hyperthyroidism, hypothyroidism and euthyroidism. Case report: A 23-year-old woman presented at otorinolafingologist with stuffy nose, sore throat and pain on the anterior neck. She was treated with antibiotic and corticosteroid inhalation therapy. After 2 weeks, the codition deteriorated with increased body temperature 37,8 oC ,appearance of malaise, loss of appetite and intensifion of the pain in the throat that spread to the upper part of the neck and ears. She was referred to an internist. А miss diagnosis of primary hyperthyroidism was made and thiamazole therapy was prescribed. After one mount from the appearance of the first simptom, the patient came in our hospital. Results: ECG - sinus tachycardia 120 beats/min. From the laboratory: suppressed TSH 0.004 mU/l and elevation of: fT4-59 pmol/l fT3-14 pmol/l, thyroglobulin-280, sedimentation- 80, CRP-30mg/l. Thyroid ultrasound: diffusely enhanced, hypoechoic, non-homogeneous with vaguely demarcated margins and absent vascularization.Thyroid scan: empty in addition to de-Quarvain thyroiditis. Positive serology for Epstein Barr virus. Our patient was treated with NSAIDs, b blockers, corticosteroids in a small dose (20 mg), advice for fluid intake and rest. Discussion: Differential diagnosis can often lead to another etiology of thyreotoxicоsis, but good anamnesis and accurate investigations lead to correct diagnosis and appoprionate treatment. Conculusion: SAT resolves spontaneously in 90-95% of cases. In some patients, analgesic therapy with NSAIDs or corticosteroids in small doses is required in order to reduce pain and symptoms of thyrotoxicosis.