Poposki, Kostadin
Preferred name
Poposki, Kostadin
Official Name
Poposki, Kostadin
Alternative Name
Костадин Попоски
Poposki K
Попоски К
Main Affiliation
27 results
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Item type:Publication, Epidemiological and clinical features of patients with Clostridoides difficile infection(Elsevier BV, 2024-12); ; Georgievska, DajanaAIM Investigation and identification of epidemiological characteristics, risk factors and treatment regimens effectivity in reducing morbidity and mortality. BACKGROUND C.difficile remains the leading cause of health care associated diarrhea, usually as a result of irrational use of antimicrobial therapy. METHODS Retrospective descriptive study (October 2020-january2024) included all patients with clinical symptoms of Clostridoides difficile infection (CDI) admitted at our clinic. Diagnosis is based on isolation with coproculture for C.difficile, toxin confirmation with immunochromatography, small number confirmed with PCR film array. RESULTS 594 inpatients with clinical symptoms of CDI were evaluated and diagnosis was confirmed in 44. Average mean age was 58,5 (29-90)years, approximately with no differencies on sex representation. Comorbidities and previous hospitalisations were noted in two third of them, and 63% had used antimicrobial drugs, while 34% had history of corticosteroid usage and 4,5% imunosupressive therapy. Often used antibiotics cephalosporins, clindamycine, quinolones and macrolides. 68,2% had history of protein pump inhibitors usage. Culture positive were 38%, toxinA/B is confirmed with immunochromatography in 77% of patients, PCR film array confirmed C.difficile toxin A/B in the remaining patients. Treatment is carried out with oral vancomycine in 56% of patients, 15% with metronidazole and the remaining with combination of two drugs. Regarding outcomes 90% of patients were cured while 10% had fatal outcomes and CDI is not considered the main cause of death. CONCLUSION Elderly patients with antibiotic history treatment, previous healthcare exposures and comorbidities were the most affected by CDI infection. Metronidazole and vancomycine has shown good therapeutic results. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute Thyroiditis Associated with Brucellosis: A Case Report(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/ Sciendo, 2019-10-01); ; ; Brucella thyroiditis represents an extremely rare focal form of brucellosis. In this case report we describe a 55 years old male, diagnosed with brucellosis and peripheral arthritis with subsequent development of acute thyroiditis. The symptoms duration consistent with brucellosis started two weeks before establishing the diagnosis. Only a day after diagnosis and initiation of antibrucellar treatment, acute non-suppurative thyroiditis suddenly manifested. Thyroiditis was diagnosed with clinical inspection and confirmed by ultrasound investigation. With the appropriate antibrucellar treatment, complete cure of thyroid affection was reached in ten days and the patient remained well during the follow-up period of two and a half years. In conclusion, in brucellosis endemic regions brucellosis should be included in the diagnostic consideration in patients with acute non-suppurative thyroiditis. Early recognition and adequate treatment of brucella thyroiditis results in favorable outcome.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CURRENT SITUATION IN CHEMOPROPHYLAXIS AND THERAPEUTIC TREATMENT OF COVID-19(Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, 2022); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Visceral Leishmaniasis in the Republic of North Macedonia: A Retrospective Cohort Study(Galenos Yayinevi, 2025-11-11); ; Visceral leishmaniasis (VL) is a systemic protozoan vector-borne disease and represents the most severe clinical form of leishmaniasis, with fatal outcomes if left untreated. This study aimed to evaluate the key epidemiological, clinical, and laboratory findings, treatment options, and outcomes in patients with VL. Materials and Methods A retrospective analysis was conducted on the epidemiological and clinical characteristics of 84 patients diagnosed and treated for VL at the University Hospital for Infectious Diseases in Skopje, Republic of North Macedonia (RNM), between 2001 and 2023. Results The median age of patients was 47 years (range 1-74), with 77.4% being male. Contact with dogs was reported in 41.7% of cases. Seven percent of patients were immunosuppressed, and all were Human Immunodeficiency Virus-negative. The median time from symptom onset to diagnosis was 30 days (range 4-330 days). The predominant clinical manifestations were splenomegaly (97.6%), fever (96.4%), hepatomegaly (90.5%), and weight loss (54.8%). On admission, anemia, leukopenia, thrombocytopenia, and hypergammaglobulinemia were detected in 75%, 73.8%, 70.2%, and 63.1% of patients, respectively. A favorable outcome was achieved in 91.7% of cases; therapeutic failure occurred in 1.2%, and 7.1% of patients died. Conclusion VL should be considered a crucial differential diagnosis in patients from the RNM presenting with prolonged unexplained fever, splenomegaly, cytopenia, and hypergammaglobulinemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTIMICROBIAL RESISTANCE PROFILES OF DIARRHEAL PATHOGENS ISOLATED FROM HOSPITALIZED ADULT PATIENTS WITH ACUTE GASTRO-ENTERITIS,(SHMSHM - AAMD, 2025); ; Background: Acute gastroenteritis is a self-limiting disease, but in high-risk patients for bacteremia like neonates and immunocompromised patients, appropriate antimicrobial treatment is required. Antimicrobial resistance (AMR) has become a global health challenge, particularly in bacterial pathogens causing gastrointestinal infections, thus per protocol treatment is necessary. Material and methods: This retrospective descriptive study included 200 in-patients with acute gastroenteritis, at the University Clinic for Infectious Diseases, Skopje, between July 2022 and August 2024. Stool samples were collected and tested by standard microbiological methods. Antimicrobial resistance profiles of isolates were determined by the disc-diffusion technique according to EUCAST. Results: Among 200 patients analyzed, 53% were confirmed to have an infectious etiology, with Salmonella enteritis group D as the predominant pathogen (36%), followed by Clostridium difficile and Campylobacter jejuni (6%). S. typhimurium was isolated in one patient. Viral etiology like Norovirus and Rotavirus was detected in 4,5% of cases. Resistance to ampicillin was observed in all Salmonella isolates, while C. jejuni showed no resistance to standard antimicrobial therapy. We lack data on C. difficile susceptibility. Conclusions: These findings provide insights in the most commonly found diarrheal pathogens in our setting and the resistance trends, for which reason further and appropriate empirical treatment options in patients with acute gastroenteritis should be explored. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Imported tick-borne encephalitis in a traveller returning to North Macedonia from Switzerland June 2024(Oxford University Press (OUP), 2025-03-11); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Visceral leishmaniasis as a leading cause of fever of unknown origin in immunocompetent adults: a prospective, observational, single-center study(Pensoft Publishers, 2025-12-18); ; ; Trajkova, IrenaTo evaluate the presentation patterns of visceral leishmaniasis (VL) as a cause of fever of unknown origin (FUO) and compare them with other FUO etiologies. Materials and methods This prospective observational study was conducted at the Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of North Macedonia, from 2019 to 2025. We included ninety-four immunocompetent patients, aged 14 or over who met the FUO criteria by Durack and Street and had a definitive etiology subsequently established. Based on the final diagnosis, patients were categorized into those with VL and those with alternative FUO etiologies. Demographic, clinical, and laboratory data from standardized investigations were compared between the groups using appropriate statistical tests. Results Sixty-six percent of participants were male, and their median age was 49 years (IQR 36–65). Infectious diseases were responsible for 52.1% of all FUO cases, followed by noninfectious inflammatory disorders (20.2%), miscellaneous causes (17%), and malignancies (10.6%). VL was the leading single diagnosis, identified in 17% of the total cohort. Compared with non-VLFUO cases, VL patients more often presented with weight loss, diaphoresis, and splenomegaly (all <0.001), hepatomegaly ( =0.002), and higher febrile peaks (p=0.026). Hematologic abnormalities were more pronounced in VL, with lower hemoglobin, hematocrit, leukocyte, and platelet counts (all p≤0.006), as well as lower albumin (p=0.029) and higher globulin levels (p=0.001). Conclusion Visceral leishmaniasis can be an important yet underrecognized cause of FUO in endemic regions. Greater clinical awareness and early diagnostic testing are essential to prevent delays and inappropriate treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiological and clinical characteristics of imported falciparum malaria in the Republic of North Macedonia : A 13-year experience(Springer Science and Business Media LLC, 2023-04-03); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical characteristics of human brucellosis in different age groups in the Republic of North Macedonia-A case series(Springer Science and Business Media LLC, 2024-12-04); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, De Ritis сооднос кај пациентис со хроничен хепатитис Б(Macedonian Infectious Diseases Society, 2023-11);
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