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    The Pillars of the Nose-Crura Shortening for Over Projected Nose
    (Scientific Foundation SPIROSKI, 2019-12-15)
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    Petreska-Dukovska, Vesna
    The over projected nose, commonly referred to as the "Pinocchio" nose is a significant challenge to the rhinoplasty surgeon. Firstly, we speak about a very large nose, and secondly, we speak about the correction of nasal cartilages (alar and triangular). Surgical correction of the over projected nose is the most difficult and least predictable component of rhinoplasty surgery.
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    Invasive Fungal sinusitis in post COVID-19 patient with multiple comorbidities - case report
    (Macedonian Otorhinolaryngology society, 2022-06-01)
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    Introduction: Secondary invasive Fungal Infections (FI) involving paranasal sinuses is a rare life-threatening opportunistic infection in immunocompromised individuals. The number of patients with FI is rising constantly globally due to the use of immunosuppressant drugs, increased use of antibiotics(AB) and long hospital stay. The critical point for sharp increase in FI Sinusitis was in post COVID-19 Patients with overuse of AB and comorbidities like Diabetes. Case Presentation: A 68 Year old male patient with multiple comorbidities including Diabetes Melitus 2, was admitted in the state Covid center (GOB 8mi septemvri) and treated 13 days for Covid complications including pneumonia with multiple AB and corticosteroid drugs, including insulin. After hospital discharge, he presented severe headache with dizziness and was hospitalized for 4 days in the neurology clinic. Another course of AB drugs was conveyed because of the lab inflammatory markers, while a specific diagnose was found. The patient developed new symptoms including bulbar propulsion, blurred vision, and somnolence. A CT scan was performed on the second day where an invasive sinusitis with orbital and susp. intracranial complications were found. The patient was urgently transferred to our clinic and prepared for surgical treatment. An orbital abscess incision and FESS (including orbital decompression) was performed. Massive pus collections ware drained. During the ethmoidal openings a classical sign of fungal sinusitis with fungal hypha’s were found and eradicated. Beside the complete and successful endonasal operation the patient situation post op was worsening and he was transferred to the intensive care unit on mechanical ventilation, with complication of cavernous sinus thrombosis. Two days later the patient destabilized and died. Conclusion: COVID-19 patients required multidisciplinary approach in treatment and post hospital care, including ENT specialist. Patient comorbidities should remain in focus during the treatment of the primary illness. The lack of protocols at the start of the pandemics lead to overuse of drugs, such as AB and corticosteroids. Every patient should be individually accessed for determining the right diagnose auspicious.
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    COMPARATIVE STUDY BETWEEN JODOFORM-VASELINE NASAL PACKING AND MEROCEL HEMOX 10 cm AFTER THE SEPTO-TURBINOPLASTY OR RHINOSEPTOPLASTY PROCEDURE
    (European Rhinologic Society, 2019-04-04)
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    Background: The purpose of our study was to compare Merocel (Merocel Hemox 10 cm) and Jodoform-Vaseline cotton tampons (JVT) after a rhinoseptoplasty procedure in efficiency and patient comfort. Methods: We carried out a prospective study of 53 patients who had undergone surgery between 01/2018 and 01/2019. GroupA, packed with Merocel was composed of 29 patients, and GroupB packed with JVT was composed of 24 patients. A standard scale ranging from zero (no symptoms) to 5 (most severe symptoms) was used to assess subjective symptoms. To compare the usefulness of materials we evaluated the after-surgery bleeding and bleeding after nasal pack removing, discomfort of the patient at 12h and after 72h, discomfort during removing nasal pack. Secretions and crusts were evaluated 1 week and 2 weeks after surgery in both groups. Results: A total of 53 patients were enrolled in the study, 37 women and 16 men; age range 15-42 with a mean age of 34 years. After removing of the nasal pack in the GroupA, in 27 cases no bleeding was present, and in 2 cases there was present bleeding. In the GroupB in 19 cases no bleeding was present, and in 5 cases there was present bleeding. In the GroupA overall average discomfort score was 2, and in the GroupB overall average discomfort was 3. We noticed statistically significance reduction of nasal secretions and crusts at 1 week after surgery. The difference is not statistically significant 2 weeks after surgery. Difference in discomfort related to nasal packing is statistically significant (p < 0.05) regarding the pain during packing removal, the general satisfaction and the pressure. Conclusions: Merocel Hemox 10 cm was easily implanted and removed, causing patients less discomfort during the first days after surgery. The nasal mucosa was better preserved with Merocel than with JVT. This type of material can be used in rhino-septoplasty or septoturbinoplasty.
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    EVALUATING CHRONIC RHINOSINUSITIS AS A COMORBID DRIVER IN COPD
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-07-18)
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    Debreshlioska, Angjela
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    Introduction: Chronic rhinosinusitis (CRS) is increasingly recognized as a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD), particularly under the framework of the “united airways” model, which emphasizes shared inflammatory mechanisms across the upper and lower respiratory tract. Aim: To evaluate inflammatory biomarker profiles among COPD patients with and without CRS, and to assess differences across distinct COPD phenotypes—non-exacerbators (NE), frequent exacerbators (E), and asthma-COPD overlap (ACO). Material and methods: A cross-sectional study was conducted on 36 COPD patients at a university clinic in Skopje, including 21 with CRS and 15 patients without CRS. All participants underwent clinical phenotyping, nasal endoscopy, sinus CT, and serum biomarker analysis (IL-4, IL-5, IL-6, IL-8, CRP, leukocytes). Statistical comparisons were made using Mann–Whitney U and Kruskal–Wallis tests. Results: CRS was predominantly found in patients with the ACO phenotype (71.4%, p = 0.0006). No statistically significant differences were observed in systemic biomarkers (IL‑4, IL‑5, IL‑6, IL‑8, CRP, leukocytes) between COPD patients with and without CRS. IL‑5 and IL‑6 were undetectable. Similarly, inflammatory profiles did not significantly differ among COPD phenotypes. Conclusion: CRS appears disproportionately represented in the ACO phenotype, likely due to shared type‑2 inflammatory pathways. However, conventional systemic biomarkers lack the sensitivity to detect upper airway involvement or differentiate COPD phenotypes. These findings highlight the need for comprehensive airway assessment and more specific biomarkers in future studies to better understand the interplay between CRS and COPD.
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    Microscopic techniques of cholesteatoma surgery
    (2023-10)
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    Tashkovska, E
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    Cholesteatoma of the middle ear or/and mastoid is an erosive process defined by trapped squamous epithelium that produces and accumulates desquamated keratin debris with/without a surrounding inflammatory reaction. Due to its aggressive growth and invasive nature, cholesteatoma tends to cause extracranial and potentially fatal intracranial complications. Otitis media with cholesteatoma is considered an unsafe ear and currently surgery is the definitive line of management with an aim to create a safe and dry ear by exteriorizing the disease and improving hearing. There are different approaches used worldwide and each surgeon has his own beliefs and conceptions/misconceptions. Two main options in cholesteatoma surgery are the canal wall up and canal wall down mastoidectomy. The quest for better surgical outcome has continued to raise challenges and the choice of the surgical technique is always a matter of debate. Hence otologists are in search of a tailored and more adaptable technique. No single method is optimal in all cases of cholesteatoma, so cholesteatoma surgery should be individualized and the choice of the operative procedure based on the extent of the disease and condition of the ME cleft, the needs of the patient, and the surgeon’s experience. Both canal wall–up and canal wall–down mastoidectomies can be utilized successfully in the management of cholesteatomas as long as the operative techniques are performed correctly and appropriate patient selection occurs.
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    Rare case of inverted papilloma with single insertion of the nasal septum and no local destruction
    (Macedonian Otorhinolaryngology society, 2022-06-01)
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    Arnautovska, Bodganka
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    Abdulai, Valdrin
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    Varoshanska, Brankica
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    Introduction: Inverted papilloma (IP) is the second most common benign lesion in the sinonasal region, and the most common surgical indication for benign tumors of the sinonasal tract. The lesion is estimated to represent 0.4% to 4.7% of all surgically removed nasal tumors, with an incidence ranging from 0.74 to 2.3 new cases per 100,000 inhabitants per year. The most common insertion site of the IP is the lateral nasal cavity, and the maxillary or frontal sinus(up to 30%). The septal insertion in progressive IP is extremely rare. Case Presentation: A 68 year old male patient visited our institution with difficulties in nasal breathing that were worsening in the last 2 years. Basic ENT exam was performed including otoscopy and oropharyngoscopy being without any notable pathology. Fiberendoscopic evaluation of the nose showed tumor mass that macroscopically looked like papilloma, filling the entire left nasal cavum and blocking the posterior part of the right nasal cavity. CT scan was performed indicating that the tumor mass fills the entire left nasal cavum, the larger portion of the epipharynx, blocking both the choanal openings. Functional Endoscopic Sinus Surgery was performed, during which the tumor mass was totally removed with its insertion on the nasal septum in the left nasal cavum. Hystopathological analisys confirmed the macroscopic findings and showed that the mass is inverted papilloma. Conclusion: The preoperative diagnostics and planning of an operation are crucial for the outcome of the treatment. Detecting and radically removing the insertion of the IP is the main challenge intraoperatively. Unusual sites of origin must not diverge us from the total and radical removal of the tumor. Histopathologic confirmation of the whole operative specimen is concluding the successful treatment. Keywords: Inverted Papilloma, Endoscopic nasal surgery, Sinonasal Tumors, Human Papilloma Virus (HPV)
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    Rare Case Of Deep Neck Infection
    (2020-11-10)
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    Milceska, E
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    Sulejmani, S
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    Arnautovska, B
    Introduction: Deep neck infections are a serious but treatable group of infections affecting the deep cervical space and characterized by rapid progression and life-threatening complications. These infections remain an important health problem with significant morbidity and potential mortality. These infections most frequently arise from the local extension of infec - tions from tonsils, parotid glands, cervical lymph nodes, and odontogenic structures. They classically present with symptoms related to local pressure effects on the respiratory, nervous, or gastrointestinal tract (particularly neck mass/swelling/ induration, dysphagia, dysphonia, and trismus). The specific presenting symptoms will depend on the deep neck space involved (parapharyngeal, retropharyngeal, prevertebral, submental, masticator, etc) Objectives: To present a successful management of a 68 year old patient with severe deep neck infection, despite the unknown origin of the infection focus. Material and Methods: A 68 year old male patient visited ENT Clinic on day 1 without specific pain, only with slight neck edema in front of the laryngeal box. The edema was non painful and soft, without affection of lateral neck lymph nodes. Oropharyngoscopy - there were no pathologic findings. Fibernasolaryngoscopy - sufficient breathing canal, without specific pathological signs. The patient had diabetes mellitus, treated with oral antidiabetic drug for more than 5 years. The patient was set on double course –antibiotic per -os therapy (3rd gen. cephalosporin and macrolide), corticosteroids and painkiller. On day 3 the patient condition was getting worse so on his second visit to the ENT specialist his neck was swelled, red, warm and painful with severe edema spreading towards jugulum, and immediate hospitalization was required. The patient was set on double Antibiotic I.V therapy, I.V corticosteroids, and insulin injections. His biochemistry results showed severe raise of inflammatory parameters. Second day after the hospitalization his breathing was affected, led by fibernasolaryngoscopy evaluation that showed hyperemia of hypopharyngeal and laryngeal structures affecting the breathing space. Urgent tracheostomy and neck incision were performed under endotracheal anesthesia. During the neck incision massive purulent secretion was drained. The patient was left with an open wound for daily treat - ment and inspection. In the next days the patient’s neck incision was locally treated with antibiotic, and drained from pus. CT scan and microbiological swab and aspiration were performed during the next 5 days. The patient was switched to vancomycin after the microbiology results (Enterococcus). Results: After 15 days of constant care, twice daily local treatment of the wound, the inflammatory parameters started set - tling to normal values, and the local finding was improved. The larynx and hypopharynx inflammation was resolved. The patient was stable and subjective feeling was well. The main problem left was the intermediate skin defect due to prolonged treatment and skin necrosis. Conclusion: Deep neck infection can be capricious condition in which the time and reaction in treatment can be of life essence. Many other conditions and comorbidity can affect the course and the outcome of the treatment. Hospital treatment and constant follow up of the patient can give the healthcare professionals position to react accordingly.
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    Complication of ignored Foreign body in the respiratory tract
    (Macedonian Otorhinolaryngology society, 2022-06-01)
    Micevski, Goran
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    Kamsikovski, Igor
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    Complications of ignored foreign body in the respiratory tract Introduction: Foreign body aspiration is an emergency condition and may be fatal. Delayed diagnosis and treatment may be associated with complications. Objective: This study evaluated the association between complication of delayed treatment and complications during the procedure of extracting. Materials and methods: Foreign bodies are not normally found in the respiratory tract. The complications of delayed treatment could be: obstructive emphysema, atelectasis, tracheoesophageal fistula, bronchiectasis, haemoptysis, lung abscess, bronchopleural fistula, pneumonia, persistent coughing. Complications during treatment could be: coughing, dyspnoea, wheezing, stridor, haemoptysis, asphyxia, laryngeal oedema, pneumothorax, pneumomediastinitis, tracheobronchial rupture, cardiac arrest. The analysis is to be executed for the period 2016- 2021 year and the data for the survey were obtained from the records of the Department of Ear, Nose and Throat at the University Clinical Centre in Skopje. Results: All entities that can be aspirated, it can be said that organic, vegetal foreign bodies cause the biggest problems are the most dangerous and life treating conditions, given their unique nature and specific physical and chemical properties. Conclusion: A history of sudden-onset choking and cough, plus abnormal auscultation and radiological findings, are leading signs in the profile of foreign body aspiration. In these patients bronchoscopy is indicated. As time passes after aspiration the risk of complications is higher. The high prevalence of foreign bodies of vegetal origin is seen in children younger than 3 years of age.
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    Cochlear implantation and vertigo-case presentation
    (2019-10)
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    Zequiri, Besim
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    CI has become a standard of care for the patients with moderate to severe sensorineural hearing loss in the last more than 20 years. In time when the indications for CI are significantly expanded and we have wide use and application of cochlear implant it is already becoming very important to critically analyze and evaluate all the risks and possible side effects of this procedure. Postoperative vertigo it’s one of the well - known complications after cochlear implantation which has a considerable impact of patient life. It can be a consequence of many causes and the complaints can appear directly after cochlear implantation surgery or after a period of time. Postoperative vertigo it’s more common in adults, especially in one who have a history of preoperative balance disorders and long lasting deafness. Children really suffer from this complication which usually occurs in milder form. In this case report we present a 9-year-old child, a cochlear implant recipient, with recurrent episodes of vertigo appearing for the first time 6 years after the implantation. Every next episode of vertigo was milder than the previous one and well respond on standard vestibular therapy with Beathistine or Eglonyl. Exposing patient to the risk of possible balance disorders associated with CI its justified in view of the hearing rehabilitation achieved. In any case it’s necessary to inform the patient about possibility and quality of post-operative vertigo symptoms. Implementing a protocol for peri-operative evaluation of the vestibular function of specially designed questionnaires and objective tests for assessment of the vestibular function should be standard procedure for each patient who is candidate for a cochlear implant
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    Компликации од тонзиларна инфекција кај 79 год. пациент
    (2020-11-10)
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    Panev, I
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    Rafajlovski, N
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    Tashkovska E
    Вовед: Компликациите од инфективните процеси на горниот аеродигестивен тракт доколку не бидат третирани навремено можат да дадат сериозни компликации дури и да го донесат животот на пациентот во ризик. Како компликации од воспаление на палатиналните тонзили меѓу другите може да се јават абсцеси во околните простори (перитонзиларни, парафарингеални итн) како и длабоки вратни инфекции. Длабоките вратни инфекции се карактеризираат со рапидна проглесија и непредвидлив тек. Цели: Сакаме да представиме случај на 79 годишен пациент со акутен тонзилитис , којшто како компликација појавува абсцес во вратна регија и длабока вратна инфекција. Материјали и методи: 79 годишен пациент 48 часа пред хоспитализација за првпат се јавил кај матичен лекар со болка во грло и вратна регија, било администрирано антибиотик (cefixime) и кортикостероид (dexametasone). За само 24 часа општата состојба на пациентот се влошила и истиот бил препратен на специјалист-оториноларинголог од секундарно ниво, каде било констатирано изразен оток субмандибуларно, пропратен со болка при зборење и голтање којшто бил фиксиран и болен на палпација. Пациентот веднаш е препратен во терциерна ОРЛ амбуланта, каде по реализиран преглед е констатирано присуство и на перитонзиларен абсцес на десна страна којшто амбулантски е инцизиран, додадено и кортикостероид (metilprenisolone) во терапија. И покрај направената инцизија кај пациентот состојбата рапидно прогредира за да следниот ден на контролен преглед целата вратна регија е во изразен оток , предоминантно субментално и паротидно со прогресија према букален простор. Поради афекција на дишен пат, отежнато дишење, фиберскопски наод за оток на епиглотис и ларингеални структури со загозен простор за дишење кај пациентот се поставува индикација за итна трахеотомија. Истата е спроведена во ОЕТ Анестезија и покрај предизвиците за истата бидејки станува збор за пациент со нерегулирана антихипертензивна терапија и ограничен простор за интубација. Реализирана субментална инцизија со која се ослободува субментален простор и се овозможува дренажа на истиот. Пациентот е хоспитализиран на двојна антибиотска терапија, кортико терапија и константна опсервација. На дневно ниво кај истиот се прават тоалета преврски и локални промивки со антибиотик во самата инцизија. Резултати: По 4 дневен хоспитален третман пациентот е стабилен , се чека извештај од комплутеризирана томографија на глава и врат по што може ке се наложи дополнителна инцзија на некој од вратните простори. Притоа пациентот редовно се храни и хидрира, поставена назогастрична сонда. Регулирана антихипертензивна терапија , и константно следење на лабораториски параметри, од кои бие се издвоило дека за само 4 дена од хоспиталниот третман вредноста на ЦРП е намалена од 470мг/Л на 87мг/Л. Притоа при сите следни инцизии ке се внимава да не настанат големи кожни дефекти, којшто искуствено прават дополнителна компликација во натамошно заздравување. Заклучок: Компликациите од инфективните процеси на горен аеродигестивен тракт треба да се перцепираат како озбилни состојби од сите лекари, како во примарните така и во терциерните специјалистички установи. Времето е од круцијално значење во третманот на истите , и навремено превзементи медицински чекори во право време можат да го сменат текот на лекувањето.