Labudovikj, Danica
Preferred name
Labudovikj, Danica
Official Name
Labudovikj, Danica
Translated Name
Лабудовиќ, Даница
Main Affiliation
Email
danica.labudovik@medf.ukim.edu.mk
danicalabudovic@gmail.com
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Item type:Publication, Protein za prijenos kolesteril estera (CETP) i veličina čestica LDL u bolesnika s koronarnom bolešću(CROATIAN ATHEROSCLEROSIS SOCIETY, CROATIAN MEDICAL ASSOCIATION, 2019-05); ; ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Serum homocysteine levels and methylenetetrahydrofolatereductase genotypes in couples with idiopathic recurrent miscarriage(Balkan Clinical Laboratory Federation (BCLF), 2015-10); ; ; Aleksandar Senev - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Role of urinary podocalyxin in early diagnosis of diabetic nephropathy(Sciendo, 2020-08-10); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Role of Cholesteryl Ester Transfer Protein (CETP) and Lecithin Cholesterol Acyl Transferase (LCAT) in lipid metabolism(SHMSHM/AAMD, 2010); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphological and biochemical changes in Wistar rat livers after clofibrate treatment(Macedonian Association of Anatomists, 2018); ; ; ; The aim of our study was to determine whether short-term administration of clofibrate can lead to morphological changes in the Wistar rat livers and weather these changes were accompanied by changes in the specific activity of the enzymes involved in oxidative stress. Male Wistar rats divided in two groups: control and experimental were treated with saline solution and clofibrate respectively (250 mg/1000 g/day) for 12 days. Tissue liver samples were taken for morphological examination and liver homogenates and sub-cellular fractions were used for measurement ofproteins, reactive oxygen species (ROS) producing and ROS scavenging enzyme activities. Following clofibrate treatment, liver histopathology in the treated group has shown deranged liver architecture, focal necrosis and presence of atypical lymphocytes.Electron light mitochondrial matrix and increased number of peroxisomes and mitochondria were also observed. These changes were accompanied by increase of the specific activity of ROS producing enzymes (urate oxidase and palmitoyl CoA oxidase). The most prominent increase of the activity with the increase of relative sub-cellular distribution was observed in the peroxisomal fraction (LMF). Specific activity of catalase was increased, whereas superoxide dismutase and glutathione peroxidase have shown almosta double decrease. Morphological changes in the liver accompanied by ROS production which has prevailed over their removal pointed to a conclusion that clofibrate can cause morphological changes accompanied by biochemical changes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, APOLIPOPROTEIN(a) POLYMORPHISMS IN A HEALTHY MACEDONIAN POPULATION(Macedonian Academy of Sciences and Arts, 2004); ; ; Todorova BElevated lipoprotein(a) [Lp(a)] concentrations are positively correlated with premature coronary heart disease (CHD) and are thought to reflect allelic variation in apolipoprotein(a) [apo(a)], the protein unique to Lp(a). Apolipoprotein(a) exists in polymorphic forms that exhibit different apparent molecular masses. We used a 3-15% gradient polyacrylamide gel electrophoresis in sodium dodecyl sulfate (SDS-PAGE) method followed by immunoblotting to separate and visualize apo(a) forms present in plasma from 180 healthy Macedonian blood donors. One or two isoforms (relative molecular mass from 417,000 to 785,000) were present in each individual. On the hypothesis that apo(a) polymorphism is controlled by different alleles at a single locus, the frequency of the six alleles determined from the observed phenotypes was: LpB = 0.022, LpS1 = 0.028, LpS3 = 0.201, LpS4 = 0.397, Lp>S4 =0.110, LpO = 0.242. These fit the expectations of the Hardy-Weinberg equilibrium in this population. A significant inverse correlation was found between plasma Lp(a) levels and the size of Apo(a) isoforms [Pearson’s correlation coefficient (r) = –0.3477, p <0.001]. A highly skewed distribution of Lp(a) toward lower levels in the Macedonian population may be explained by the high frequencies of alleles for large apo(a) isoforms and the null allele.