Cvejoska Cholakovska, Valentina

Preferred name

Official Name

Cvejoska Cholakovska, Valentina

Alternative Name

Cholakovska CV

Colakovska CV

Cvejoska Cholakovska V

Cvejoska Colakovska Valentina

Cvejoska Colakovska V

Cvejoska Valentina

Cvejoska V

Cvejovska Valentina

Cvejovska V

Colakovska Valentina

Colakovska V

Cholakovska Valentina

Cholakovska V

Cvejovska Colakovska Valentina

Cvejovska Colakovska V

Cvejovska Cholakovska Valentina

Cvejovska Cholakovska V

Main Affiliation

valentina.cc@medf.ukim.edu.mk

vcolakovska@yahoo.com

Scopus Author ID

0000-0003-2694-9479

Now showing 1 - 10 of 13

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Density of truck traffic on residential streets and the impact on asthma and asthma-like symptoms in childhood
(European Respiratory Soc Journals LTD, 2016-09)
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Kimovska, Mica
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Background: Conflicting results have been reported, mostly in developed countries, on the relationship between traffic exposure and asthma. The aim of this study was to examine the impact of truck traffic exposure on childhood asthma in The Republic of Macedonia, as a developing country with a moderate rate of high truck traffic exposure, high dietary antioxidants intake, and previously reported low prevalence of asthma. Methods: Parental-reported data was used, obtained through standardized surveys in winter 2015-16. There were 1945 children aged 5-15 years from randomly selected schools in Skopje, the capital of Macedonia, who took part. The association between truck traffic density on residential streets on weekdays with wheeze 'ever', current wheeze, current exercise-induced wheeze, current dry night cough apart from a cold and doctor-diagnosed asthma was investigated after adjusting for potential confounders using binary multiple logistic regression. Results: Truck traffic density exposure almost the whole day was found to be 9.6%, frequently through the day 30.2%, seldom 47.7% and never 11.9%. The exposure almost the whole day increased the risk of current wheeze (aOR: 2.84; 1.20-6.70; p=0.017), wheeze 'ever' (aOR: 1.55; 0.98-2.45; p=0.061), exercise-induced wheeze (aOR: 4.19; 0.85-20.62; p=0.078) and dry night cough (aOR: 1.78; 0.96-3.33; p=0.068). There was no association with the other investigated variables, including diagnosed asthma. Conclusion: The findings suggest an adverse effect of high truck traffic exposure on asthma-like symptoms, but not on asthma, which support the hypothesis that components of air pollution act as non-specific respiratory irritants.
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Overweight/obesity and childhood asthma
(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2018)
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Childhood asthma and obesity have been increasing in recent decades worldwide. Many studies have reported an increased risk of development of asthma in overweight/obese adults and children. The complex association of overweight/obesity with asthma might be explain by the influence of genetic and epigenetic factors, external factors and mechanical factors with impaired lung function and GERD. Obesity affects lung function in obese asthmatics with decrease in FRC and ERV. In obese children a significantly decreased ratio of FEV1/FVC has been documented. Obesity is associated with low-grade systemic inflammation, giving rise to this idea obesity is a “proinflammatory state”. Adipose tissue secretes leptin, adiponectin, IL-6 and TNF-α, which may have significant effects in development of systemic and airway inflammation. AHR is also present in obese adults suffering from asthma, but data in children are inconsistent. In conclusion, there is evidence to associate asthma with obesity in children, but the data are still conflicting. Pediatric obese asthma is a distinct asthma phenotype, characterized by more severe form, steroid resistance, which requires a specialized treatment plan. As the number of obese children is expected to increase in the next decades, research on pathogenetic mechanisms, will improve the management of this chronic diseases.
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Temporal trends in asthma and asthma-like symptom prevalence in Skopje, The Republic of Macedonia
(European Respiratory Soc Journals LTD, 2016-09)
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Kimovska, Mica
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Seckova, Lidija
Background: There have been differences in temporal trends of asthma prevalence by geographic region. It is important to consider local patterns to plan health care. The aim of this study was to assess temporal trends in asthma prevalence among young adolescents in Skopje, Republic of Macedonia as a developing country. Methods: Data was obtained from 3 cross-sectional surveys (2002, 2006 and 2015) of adolescents (12-15 years) from randomly selected schools in Skopje. Trends in the prevalence of asthma and asthma-like symptoms were investigated descriptively and using multiple logistic regression to adjust for potential confounders. Results: The prevalence of asthma increased although the changes were not statistically significant (2002: 1.7%; 2006: 2.1%; 2015: 2.6%; p=0.13). The prevalence of ever wheeze differed by year (2002: 18.4%; 2006: 15.3%; 2015: 26.4%; p<0.001). Statistically significant (p<0.05) reductions in wheeze prevalence over time (2002, 2006 and 2015) were observed for current wheeze (8.8%, 7.2% and 5.9%), exercise-induced wheeze (14.2%, 7.9% and 2.1%), and night cough (16.5%, 13.6% and 10.2%). After adjustment for potential confounders, there was an increase in asthma likelihood by year compared to 2002 (2006: OR=1.35, 95%CI=0.74-2.44; 2015: OR=2.12, 95%CI=1.04-4.35). In the adjusted analyses, associations between year and the asthma-like symptoms confirmed the descriptive results. Conclusion: A significant decrease in asthma symptoms contrary to a slight increase in asthma diagnosis in Skopje during a period of 13 years was established. Improved diagnostics and treatment may explain some of these changes.
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Asymptomatic bronchogenic cyst in a six-year old girl
(Медицински факултет - Скопје, 2006)
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Nikolovski, Ljupco
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Sazdovski, Angelce
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Seckova, Lidija
Bronchogenic cysts in childhood are rare congenital anomalies resulting from the abnormal development of the tracheo-bronchial tree. They are usually found in the mediatinum around the tracheo-bronchial tree or in the lung parenchyma. We report a case of bronchogenic cyst in a six-year old girl presented with fever, cough and chest pain 7 days prior to admission in the hospital. The patient did not have history of any pulmonary disease before. The initial clinical and laboratory findings were suggestive of a lung abscess. Chest x-ray showed a round shadow with an air-fluid level in the middle parts of the right lung. Antibiotic treatment was initiated and the control chest-x ray did not show significant improvement. Computed tomography of the chest further confirmed the cyst with an air-fluid level and better defined its location and size. The cyst was removed by total excision and the histological analysis revealed its bronchogenic origin. The postoperative course was free from complications. Bronchogenic cysts are rare in childhood. Presented as a lung mass with or without infection they should be surgical treated. Surgery establishes the diagnosis and removes the symptoms, additionally preventing complications (infections, haemorrhage, pneumothorax, sudden respiratory compromise and malignant transformation),
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Antibiotics use in relation to asthma in children
(Wiley Blackwell, 2018-05)
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Kimovska, M
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Seckova, L
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Background: Early-life antibiotic exposures have been reported to increase the risk of allergic diseases. The aim of the study was to examine the impact of current antibiotics use on asthma in schoolchildren in The Republic of Macedonia, as developing country with a high rate of antibiotics use and low prevalence of asthma. Method: Data from 2310 schoolchildren aged 5-15 years obtained through a parental-completed questionnaire in randomly selected primary schools in Skopje, the capital of Macedonia, in 2015/2016 was used. The frequency of antibiotics intake ≥3 and <3 times yearly vs never antibiotics intake for respiratory infections, in the last 12 months was correlated to current asthma-like symptoms and ever-diagnosed asthma after adjustment for confounding factors using multiple logistic regression. Results: 50.9% of the children used antibiotics currently and 21.0% out of them used antibiotics ≥3 times yearly. Current wheeze (W) was established in 6.5%, sleep-disturbing W in 3.6%, exercised-induced W in 1.7%, dry night cough apart from a cold in 12.2% and asthma in 2.3%. Current antibiotics use ≥3 times yearly was positively associated with current W (aOR: 13.37; 6.14-29.11; p < 0.001), sleep-disturbing W (aOR: 7.87; 3.34-18.57; p < 0.002), dry night cough (aOR: 3.80; 2.29-6.29; p <0.001), and diagnosed asthma (aOR: 5.68; 1.96-16.50; p = 0.001) while antibiotics use <3 times yearly was positively associated only with current W (p = 0.003) and dry night cough (p = 0.011). Conclusion: The results suggest an aggravating role of antibiotics use on asthma in school age thus further supporting the recommended restriction of antibiotics exposure.
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Divergent trends in the prevalence of asthma-like symptoms and asthma in a developing country: three repeated surveys between 2002 and 2016
(Elsevier, 2020-04-10)
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Kimovska, Milica
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Lawson, Joshua A
INTRODUCTION AND OBJECTIVES: There have been differences in temporal trends of asthma prevalence by geographic region and economic prosperity. The aim of this study was to assess temporal trends in asthma prevalence among young adolescents in Skopje, Republic of North Macedonia as a developing country with a low asthma prevalence. SUBJECTS AND METHODS: Data was obtained from three cross-sectional surveys (2002, 2006, and 2016) of adolescents (12-15 years) from randomly selected schools in Skopje. Trends in the prevalence of asthma and asthma-like symptoms were investigated descriptively and using multiple logistic regression to adjust for potential confounding factors. RESULTS: The prevalence of asthma increased, although the changes were not statistically significant (2002: 1.7%; 2006: 2.0%; 2016: 2.8%; p = 0.075). Statistically significant (p < 0.05) reductions in wheeze prevalence over time (2002, 2006, 2016) were observed for current wheeze (8.8%, 7.2%, 5.5%), exercise-induced wheeze (14.2%, 7.9%, 1.9%), and night dry cough (16.5%, 13.5%, 9.6%). After adjustment for potential confounding factors, there was an increase in asthma likelihood by year compared to 2002 (2006: OR = 1.22, 95%CI = 0.67-2.22; 2016: OR = 2.45, 95%CI = 1.24-4.84). In the adjusted analyses, associations between year and the asthma-like symptoms confirmed the descriptive results, except for current wheeze, where statistical significance disappeared. CONCLUSIONS: Divergent trends in prevalence with a decrease in asthma-like symptoms and an increase in physician-diagnosed asthma in Skopje during a period of 14 years were established. Improved asthma labelling and effective preventative treatment of symptoms may explain some of these changes, although changes in environment and lifestyle could not be ruled out.
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Бронхијален карциноид кај 11 годишно машко дете
(Медицински факултет - Скопје, 2007)
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Nikolovski, Ljupco
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Sazdovski, Angelce
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Seckova, Lidija
Бронхијалните карциноиди се ретки белодробни невроендокрини неоплазми кои претставуваат 1%-2% од сите белодробни тумори. Може да манифестираат широк спектар на клиничко однесување и хистолошки карактеристики и да бидат градирани од типични карциноиди па се до атипични агресивни карциноиди. Прикажуваме машко дете на возраст од 11 години со рецидивирачки бронхити и пневмонии во тек на 1 година пред хоспитализација. Мотив за хоспитализација беа пролонгирана кашлица и градна болка. При аускултација на бели дробови регистрирано ослабено дишење и визинг во предел на десната страна на градниот кош. Рентгенграфијата на бели дробови (ртг) покажа ателектаза во предел на предниот сегмент на десниот горен лобус. Започната терапија со цефтриаксон која доведе до подобрување на состојбата. Контролната ртг не покажа ремисија. Компјутеризираната томографија (КТ) на граден кош покажа присуство на ендобронхијална маса во бронхот за предниот сегмент на десниот горен лобус. Со фибер-бронхоскопија се потврди постоење на туморозна маса во бронхот. Патохистолошкото испитување во прилог на бронхијален карциноид. Направена лобектомија при што беше отстранет горниот десен белодробен лобус. Седум години по извршената интервенција детето е во добро здравје и без симптоми на болест. Бронхијалните карциноиди се тумори кои можат да бидат малигни со можност за метастазирање. Клиничкото познавање и раната дијагноза се важни фактори во превенција на морбидитетот и морталитетот. Третманот е хируршки при што се настојува да се зачува колку е можно повеќе функционално белодробно ткиво. Со правилна навремена дијагноза и интервенција пациентите имаат одлична прогноза. По направена интервенција се препорачува понатамошно следење на пациентот.
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Pandemic with COVID-19 and Families with Children with Chronic Respiratory Diseases
(Macedonian Academy of Sciences and Arts / De Gruyter, 2020-10-02)
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Boskovska, Katerina
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COVID-19 pandemic has provoked a huge change in daily functioning in millions of people worldwide. The epidemiological measures in prevention of possible infection have increased the possible risks on the mental and physical health. We have conducted a survey in order to investigate the needs and challenges of families with children with chronic respiratory diseases. In this order, we have created a questionnaire with general information about the family, general information about the child with chronic respiratory disease, overall physical and mental health before and during the pandemic, needs and mental health condition of the parents/caregivers. This survey showed that this group of families of children with respiratory disorders have suffered financially in significant way and has changed the way they perform professional and educational patterns due to the pandemic. Most of the children were stable in their physical health, but their mental health has deteriorated. This is probably due to the regular contact with the medical staff, but not with the mental health professionals. This group of children has a significant reduction in their physical activity and increase the hours in front of TV screens. The further effect on the physical and mental health is to be investigated.
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The Association between Asthma and Obesity in Children -1 Inflammatory and Mechanical Factors
(ID Design / Scientific Foundation Spiroski, 2019-04-29)
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BACKGROUND: Association of asthma and obesity has been demonstrated in numerous epidemiological studies. However, the underlying mechanisms of the association are not well understood. Both conditions are characterized by chronic tissue inflammation, which includes numerous different inflammatory markers, and possible atopy. AIM: The study aimed to investigate the association between asthma and obesity in children and assess several of potential underlying mechanisms, including the parameters of systemic inflammation (CRP, fibrinogen) and the mechanical effect of obesity on the respiratory system through parameters of lung function. An additional aim was to examine the role of atopy in overweight children with asthma and to investigate the type of respiratory inflammation. MATERIAL AND METHODS: This prospective study included 72 patients in the age group of 7-15 years, including 38 with high body mass index (BMI), 16 with asthma and normal BMI, and 18 with asthma and high BMI for sex and age. Non-specific inflammatory markers (fibrinogen, CRP), eosinophilia, and total serum IgE were investigated. The patients underwent a skin prick test (SPT) with standard inhalant allergen extracts, measurement of fractional exhaled nitric oxide Fe (NO), and an assessment of lung function. RESULTS: In overweight groups of children we determined significantly higher values (p < 0.001) of both acute inflammatory reactants, CRP and fibrinogen, with no difference between children with and without asthma. There was a significant increase in eosinophilia, total IgE, and positive SPT in the asthmatic groups compared to the group of non-asthmatic patients (p < 0.001 for the three parameters). Compared to the group composed of overweight patients without asthma, the asthmatic patients had higher NO values (p < 0.001). No significant difference in the lung function parameters was found between the three groups (p > 0.05). CONCLUSION: A positive association between asthma and obesity with inflammation as an underlying mechanism, eosinophilic one in asthmatic patients and non-eosinophilic one in overweight patients, was determined. It seems that the lung function parameters did not differ between asthmatic patients and overweight patients. No influence of atopy in the association between asthma and obesity was verified. Further analyses of specific inflammatory markers, for an in-depth evaluation of the mechanisms leading to the association of obesity and asthma, are warranted.
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Leptin, obesity parameters and atopy among children with asthma
(Macedonian Academy of Sciences and Arts / De Gruyter, 2021-10-26)
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Leptin, as a major adipokine, positively correlates with the body’s fat, while atopy is an important feature in the development of childhood asthma. We aimed to evaluate the relationship between leptin, parameters of obesity, and atopy in children with asthma. The study included 112 children (73 boys, 39 girls, mean age 11.1±2.4). 41 were overweight, 38 had asthma and a normal body mass index (BMI), and 33 were overweight asthmatics. Serum leptin levels, BMI, waist circumference (WC), and waist to hips ratio (WHR) were measured. Skin prick test (SPT)/CAP, total serum IgE, fractional exhaled nitric oxide (FeNO), and pulmonary function tests were performed. In asthmatic children, serum leptin median level was 9.2±16.2 ng/ml, in overweight children was 30.6±21.6 ng/ml, and in overweight asthmatics was 31.1±20.3 ng/ml with a significant difference between the groups (p=0.0374), yet with a significantly lower median level in the group of children with asthma compared to the overweight children: with asthma (p=0.00001) and without asthma (p=0.00001). In the three groups of patients, BMI and WC displayed a significant positive correlation with leptin (for BMI r=0.652 vs. r=0.530 vs. r=0.563, respectively and for WC r=0.508 vs. r=0.426 vs. r=0.527, respectively). No significant correlations of leptin within atopy parameters (Eo, IgE, SPT/CAP, FeNO) in all three analyzed groups (p>0.05) was detected.Conclusion: Atopy was not confirmed as an underlying mechanism of the association between asthma and being overweight. Leptin had a significant linear correlation as a parameter of central obesity with BMI and WC in all three groups, but not with WHR.

Cvejoska Cholakovska, Valentina

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