Ivanova Panova, Daniela

Preferred name
Ivanova Panova, Daniela
Official Name
Ivanova Panova, Daniela
Main Affiliation
Email
daniela.ip@medf.ukim.edu.mk

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    METABOLIC VARIATIONS AMONG WOMEN WITH POLYCISTIC OVARY SYNDROME ACCORDING TO BODY MASS INDEX
    (Македонско лекарско друштво = Macedonian medical association, 2025-12)
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    Naumova, Rosa
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    Introduction. There is a two-way relationship between obesity and polycystic ovary syndrome (PCOS). Although most individuals with PCOS are overweight or obese, a notable number maintain a normal body mass index (BMI). The conventional diagnostic approach to PCOS, based on phenotypic characteristics, categorises patients according to ovulatory function and androgen levels. This study aimed to compare clinical, metabolic, and endocrine parameters in lean and obese women diagnosed with PCOS. Methods. This cross-sectional study enrolled a total of 89 women, aged between 18 and 40 years, diagnosed with PCOS based on the Rotterdam criteria. Participants were stratified into groups according to their BMI. Anthropometric measurements and venous blood samples were obtained for the evaluation of glucose metabolism, lipid profile, and selected endocrine parameters. Calculated indices included BMI, waist-to-height ratio (WHR), and the homeostasis model assessment of insulin resistance (HOMA-IR). Results. Among the 89 women with PCOS included in the study, 39.3% were classified as lean, while 60.7% were categorised as obese. Regardless of phenotypic variation, obese PCOS patients exhibited significantly elevated BMI and WHR, alongside increased levels of luteinizing hormone (LH), LH/FSH ratio, and free androgen index (FAI), higher insulin concentrations, insulin resistance, and dyslipidemia. Conversely, lean women with PCOS maintained normal insulin levels, lacked clinically relevant insulin resistance, and presented with normal lipid profiles. Conclusion. The results indicated significant differences in metabolic profiles between lean and obese patients with PCOS, regardless of phenotypic classification. Metabolic abnormalities were particularly pronounced in women with increased body weight, emphasising the need for focused care and implementation of preventive measures aimed at reducing the risk of long-term health complications. These findings highlight the importance of early metabolic screening in all PCOS patients, along with a personalised approach to management based on individual characteristics.
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    Association of vascular and inflammatory markers with metabolic disorders in women with polycystic ovary syndrome
    (National Library of Serbia, 2019)
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    <jats:p>Background/Aim. The prevalence of metabolic disorders, obesity and insulin resistance in women with polycystic ovary syndrome (PCOS) occur early in life and places this group at risk of cardiovascular disease. Hyperhomocysteinemia and increased C-reactive protein (CRP) activity have an effect on promoting atherosclerosis. This study was designed to evaluate whether high sensitivity (hs-CRP) and homocysteine (Hcy) are elevated in PCOS and to elucidate their possible relation to obesity, insulin resistance, or metabolic changes usually present in women suffering from PCOS. Methods. Serum concentration of hs-CRP and plasma levels of Hcy were evaluated in 73 PCOS women and 43 healthy women, together with clinical, anthropometric and hormonal parameters. Results. The mean of body mass index (BMI), waist circumference (WC), waist to hip ratio and mean concentration of luteinizing hormone (LH), testosterone, androstenedione, free androgen index, fasting insulin, homeostatic model assessment of insulin resistance (HOMA- IR), hs-CRP and Hcy were significantly higher in PCOS women compared to age-matched healthy women. There was a positive correlation between hs-CRP and BMI, WC, insulin, triglycerides (p < 0.001) and significant negative correlation with LH, sex hormone binding protein (SHGB), HOMA-IR, high density lipoprotein cholesterol (HDL-C) (p < 0.001). The Hcy concentration had a significant negative correlation with HDL-C level (p < 0.05). The present study demonstrated increased mean concentration of Hcy in hs-CRP women with PCOS. Conclusion. Our results support the use of these biomarkers in the evaluation of potential risk for cardiovascular diseases and early prognosis and treatment implications.</jats:p>
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    ADIPONECTIN AS A SERUM MARKER OF ADIPOSE TISSUE DYSFUNCTION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: CORRELATION WITH INDICATORS OF METABOLIC DISTURBANCES
    (ACTA Endocrinologica Foundation, 2018)
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    Adipose tissue is a major store of energy for the human body. Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory proteins secreted from the adipose tissue. This study aims to investigate serum levels of adiponectin and their correlation with metabolic and endocrine indices in PCOS.
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    Primary dysmenorrhea in adolescents
    (Elsevier BV, 2026-06)
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    Stankovic, Zoran B.